FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106605065> ?p ?o ?g. }

• W2106605065 endingPage "790" @default.
• W2106605065 startingPage "785" @default.
• W2106605065 abstract "We have performed a series of isotopic studies in 25 adult patients with sepsis and/or trauma in order to determine the metabolic effects of recombinant human growth hormone (rHGH) administration. Twelve of the patients were receiving total parenteral nutrition, and 13 were eating a normal ward diet and were studied postabsorption. Energy and protein kinetics were quantified isotopically before rHGH administration and following a 3-day course of rHGH (20 units subcutaneously daily). In the total parenteral nutrition group the rate of net loss of protein decreased from 0.82(0.17) g kg-1 day-1 to 0.43(0.20) g kg-1 day-1 (P less than 0.02) following the administration of rHGH. The rate of appearance of leucine was not altered, suggesting that the improvement in nitrogen balance following rHGH was because of an increased rate of protein synthesis rather than reduced catabolism. In the postabsorptive group, rHGH treatment significantly increased the rate of appearance of free fatty acids (from 7.4(2.2) mumol kg-1 min-1 to 11.1(2.6) mumol kg-1 min-1, P less than 0.03) and free fatty oxidation (from 1.3(0.4) mumol kg-1 min-1 to 1.7(0.4) mumol kg-1 min-1, P less than 0.06), while the rate of leucine oxidation was reduced (from 0.44(0.05) mumol kg-1 min-1 to 0.26(0.03) mumol kg-1 min-1, P less than 0.005). Glucose appearance and oxidation remained unchanged. These results suggest that fat was being oxidized in preference to protein, which resulted in a reduction in the net rate of loss of protein of 0.3 g kg-1 day-1 (P less than 0.05). We conclude that rHGH administration is capable of significantly reducing net protein loss in septic or injured surgical patients. Recombinant HGH may be clinically useful in supporting critically ill surgical patients who require intensive nutritional support." @default.
• W2106605065 created "2016-06-24" @default.
• W2106605065 creator A5014704218 @default.
• W2106605065 creator A5030635807 @default.
• W2106605065 creator A5060905415 @default.
• W2106605065 creator A5062646929 @default.
• W2106605065 date "1990-07-01" @default.
• W2106605065 modified "2023-10-15" @default.
• W2106605065 title "Metabolic effects of recombinant human growth hormone: Isotopic studies in the postabsorptive state and during total parenteral nutrition" @default.
• W2106605065 cites W150236024 @default.
• W2106605065 cites W1583991926 @default.
• W2106605065 cites W173889134 @default.
• W2106605065 cites W1844670809 @default.
• W2106605065 cites W1883642995 @default.
• W2106605065 cites W1974394123 @default.
• W2106605065 cites W1983176108 @default.
• W2106605065 cites W1984510069 @default.
• W2106605065 cites W1985526577 @default.
• W2106605065 cites W1987711508 @default.
• W2106605065 cites W2026394198 @default.
• W2106605065 cites W2041187267 @default.
• W2106605065 cites W2044120869 @default.
• W2106605065 cites W2045603080 @default.
• W2106605065 cites W2057120327 @default.
• W2106605065 cites W2061425680 @default.
• W2106605065 cites W2072914768 @default.
• W2106605065 cites W2075124932 @default.
• W2106605065 cites W2075397760 @default.
• W2106605065 cites W2075715012 @default.
• W2106605065 cites W2080706511 @default.
• W2106605065 cites W2082522509 @default.
• W2106605065 cites W2087258028 @default.
• W2106605065 cites W2124232607 @default.
• W2106605065 cites W2131501155 @default.
• W2106605065 cites W227983827 @default.
• W2106605065 cites W2401725896 @default.
• W2106605065 doi "https://doi.org/10.1002/bjs.1800770722" @default.
• W2106605065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2116934" @default.
• W2106605065 hasPublicationYear "1990" @default.
• W2106605065 type Work @default.
• W2106605065 sameAs 2106605065 @default.
• W2106605065 citedByCount "107" @default.
• W2106605065 countsByYear W21066050652015 @default.
• W2106605065 countsByYear W21066050652016 @default.
• W2106605065 crossrefType "journal-article" @default.
• W2106605065 hasAuthorship W2106605065A5014704218 @default.
• W2106605065 hasAuthorship W2106605065A5030635807 @default.
• W2106605065 hasAuthorship W2106605065A5060905415 @default.
• W2106605065 hasAuthorship W2106605065A5062646929 @default.
• W2106605065 hasBestOaLocation W21066050651 @default.
• W2106605065 hasConcept C1008401 @default.
• W2106605065 hasConcept C126322002 @default.
• W2106605065 hasConcept C134018914 @default.
• W2106605065 hasConcept C178790620 @default.
• W2106605065 hasConcept C185592680 @default.
• W2106605065 hasConcept C197683979 @default.
• W2106605065 hasConcept C2776580952 @default.
• W2106605065 hasConcept C2778384902 @default.
• W2106605065 hasConcept C2779572773 @default.
• W2106605065 hasConcept C515207424 @default.
• W2106605065 hasConcept C537208039 @default.
• W2106605065 hasConcept C55493867 @default.
• W2106605065 hasConcept C62231903 @default.
• W2106605065 hasConcept C71315377 @default.
• W2106605065 hasConcept C71924100 @default.
• W2106605065 hasConcept C78722104 @default.
• W2106605065 hasConcept C8101879 @default.
• W2106605065 hasConcept C96942376 @default.
• W2106605065 hasConceptScore W2106605065C1008401 @default.
• W2106605065 hasConceptScore W2106605065C126322002 @default.
• W2106605065 hasConceptScore W2106605065C134018914 @default.
• W2106605065 hasConceptScore W2106605065C178790620 @default.
• W2106605065 hasConceptScore W2106605065C185592680 @default.
• W2106605065 hasConceptScore W2106605065C197683979 @default.
• W2106605065 hasConceptScore W2106605065C2776580952 @default.
• W2106605065 hasConceptScore W2106605065C2778384902 @default.
• W2106605065 hasConceptScore W2106605065C2779572773 @default.
• W2106605065 hasConceptScore W2106605065C515207424 @default.
• W2106605065 hasConceptScore W2106605065C537208039 @default.
• W2106605065 hasConceptScore W2106605065C55493867 @default.
• W2106605065 hasConceptScore W2106605065C62231903 @default.
• W2106605065 hasConceptScore W2106605065C71315377 @default.
• W2106605065 hasConceptScore W2106605065C71924100 @default.
• W2106605065 hasConceptScore W2106605065C78722104 @default.
• W2106605065 hasConceptScore W2106605065C8101879 @default.
• W2106605065 hasConceptScore W2106605065C96942376 @default.
• W2106605065 hasIssue "7" @default.
• W2106605065 hasLocation W21066050651 @default.
• W2106605065 hasLocation W21066050652 @default.
• W2106605065 hasOpenAccess W2106605065 @default.
• W2106605065 hasPrimaryLocation W21066050651 @default.
• W2106605065 hasRelatedWork W194806646 @default.
• W2106605065 hasRelatedWork W2006422120 @default.
• W2106605065 hasRelatedWork W2016803694 @default.
• W2106605065 hasRelatedWork W2042523519 @default.
• W2106605065 hasRelatedWork W2050747855 @default.
• W2106605065 hasRelatedWork W2061268672 @default.
• W2106605065 hasRelatedWork W2077407593 @default.

• next