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- W2106608941 abstract "Over a 10-year period in a Down syndrome Clinic, 11 children and adolescents were encountered with a history of new-onset (8) or worsening (3) autistic characteristics. Ten of the 11 (91%) had cognitive decline to a dementia-like state and 9 of the 11 (82%) new-onset insomnia. The mean age at which symptoms developed was 11.4 years (standard deviation = 3.6 years; range 5-14 years), an older age than usual for autistic regression in Down syndrome. Ten of 11 cases (91%) had elevated (“positive”) thyroperoxidase antibody titers compared to only 5 of 21 (23%) age-matched control subjects with Down syndrome ( P < .001). At follow-up at a mean age of 20.7 years (standard deviation = 3.9 years), 8 of the 11 (73%) were at least somewhat better. Down syndrome disintegrative disorder seems an appropriate name for this newly recognized clinical association, which may be due to autoimmunity." @default.
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- W2106608941 date "2014-11-03" @default.
- W2106608941 modified "2023-10-18" @default.
- W2106608941 title "Down Syndrome Disintegrative Disorder" @default.
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- W2106608941 doi "https://doi.org/10.1177/0883073814554654" @default.
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