FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106610080> ?p ?o ?g. }

• W2106610080 endingPage "1893" @default.
• W2106610080 startingPage "1879" @default.
• W2106610080 abstract "Loss of apicobasal polarity is a hallmark of epithelial pathologies. Leukocyte infiltration and crosstalk with dysfunctional epithelial barriers are crucial for the inflammatory response. Here, we show that apicobasal architecture regulates the adhesion between hepatic epithelial cells and lymphocytes. Polarized hepatocytes and epithelium from bile ducts segregate the intercellular adhesion molecule 1 (ICAM-1) adhesion receptor onto their apical, microvilli-rich membranes, which are less accessible by circulating immune cells. Upon cell depolarization, hepatic ICAM-1 becomes exposed and increases lymphocyte binding. Polarized hepatic cells prevent ICAM-1 exposure to lymphocytes by redirecting basolateral ICAM-1 to apical domains. Loss of ICAM-1 polarity occurs in human inflammatory liver diseases and can be induced by the inflammatory cytokine tumor necrosis factor alpha (TNF-α). We propose that adhesion receptor polarization is a parenchymal immune checkpoint that allows functional epithelium to hamper leukocyte binding. This contributes to the haptotactic guidance of leukocytes toward neighboring damaged or chronically inflamed epithelial cells that expose their adhesion machinery." @default.
• W2106610080 created "2016-06-24" @default.
• W2106610080 creator A5000572178 @default.
• W2106610080 creator A5001688838 @default.
• W2106610080 creator A5003198351 @default.
• W2106610080 creator A5005073507 @default.
• W2106610080 creator A5006630765 @default.
• W2106610080 creator A5019047604 @default.
• W2106610080 creator A5023973233 @default.
• W2106610080 creator A5036568942 @default.
• W2106610080 creator A5046506843 @default.
• W2106610080 creator A5050640639 @default.
• W2106610080 creator A5052350511 @default.
• W2106610080 creator A5065868209 @default.
• W2106610080 creator A5082034178 @default.
• W2106610080 date "2014-09-01" @default.
• W2106610080 modified "2023-10-14" @default.
• W2106610080 title "Apicobasal Polarity Controls Lymphocyte Adhesion to Hepatic Epithelial Cells" @default.
• W2106610080 cites W1547632219 @default.
• W2106610080 cites W1560660915 @default.
• W2106610080 cites W1690185597 @default.
• W2106610080 cites W1913785883 @default.
• W2106610080 cites W1966093122 @default.
• W2106610080 cites W1967737783 @default.
• W2106610080 cites W1967813938 @default.
• W2106610080 cites W1972204116 @default.
• W2106610080 cites W1973200119 @default.
• W2106610080 cites W1973631445 @default.
• W2106610080 cites W1975405461 @default.
• W2106610080 cites W1988326309 @default.
• W2106610080 cites W1990282533 @default.
• W2106610080 cites W1991150556 @default.
• W2106610080 cites W2003081532 @default.
• W2106610080 cites W2003649795 @default.
• W2106610080 cites W2013376648 @default.
• W2106610080 cites W2014595251 @default.
• W2106610080 cites W2018323316 @default.
• W2106610080 cites W2025835378 @default.
• W2106610080 cites W2026065539 @default.
• W2106610080 cites W2026647673 @default.
• W2106610080 cites W2028627377 @default.
• W2106610080 cites W2029729737 @default.
• W2106610080 cites W2042101513 @default.
• W2106610080 cites W2042140414 @default.
• W2106610080 cites W2042400975 @default.
• W2106610080 cites W2042800863 @default.
• W2106610080 cites W2045637671 @default.
• W2106610080 cites W2059660523 @default.
• W2106610080 cites W2063716351 @default.
• W2106610080 cites W2068318644 @default.
• W2106610080 cites W2077125401 @default.
• W2106610080 cites W2090942593 @default.
• W2106610080 cites W2094586624 @default.
• W2106610080 cites W2105053143 @default.
• W2106610080 cites W2133535035 @default.
• W2106610080 cites W2135828233 @default.
• W2106610080 cites W2146476008 @default.
• W2106610080 cites W2148399283 @default.
• W2106610080 cites W2155145471 @default.
• W2106610080 cites W2157865592 @default.
• W2106610080 cites W2164491927 @default.
• W2106610080 cites W2170597468 @default.
• W2106610080 cites W2182326252 @default.
• W2106610080 cites W2335450118 @default.
• W2106610080 cites W29987520 @default.
• W2106610080 cites W303250637 @default.
• W2106610080 doi "https://doi.org/10.1016/j.celrep.2014.08.007" @default.
• W2106610080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25242329" @default.
• W2106610080 hasPublicationYear "2014" @default.
• W2106610080 type Work @default.
• W2106610080 sameAs 2106610080 @default.
• W2106610080 citedByCount "17" @default.
• W2106610080 countsByYear W21066100802015 @default.
• W2106610080 countsByYear W21066100802016 @default.
• W2106610080 countsByYear W21066100802017 @default.
• W2106610080 countsByYear W21066100802019 @default.
• W2106610080 countsByYear W21066100802021 @default.
• W2106610080 countsByYear W21066100802022 @default.
• W2106610080 countsByYear W21066100802023 @default.
• W2106610080 crossrefType "journal-article" @default.
• W2106610080 hasAuthorship W2106610080A5000572178 @default.
• W2106610080 hasAuthorship W2106610080A5001688838 @default.
• W2106610080 hasAuthorship W2106610080A5003198351 @default.
• W2106610080 hasAuthorship W2106610080A5005073507 @default.
• W2106610080 hasAuthorship W2106610080A5006630765 @default.
• W2106610080 hasAuthorship W2106610080A5019047604 @default.
• W2106610080 hasAuthorship W2106610080A5023973233 @default.
• W2106610080 hasAuthorship W2106610080A5036568942 @default.
• W2106610080 hasAuthorship W2106610080A5046506843 @default.
• W2106610080 hasAuthorship W2106610080A5050640639 @default.
• W2106610080 hasAuthorship W2106610080A5052350511 @default.
• W2106610080 hasAuthorship W2106610080A5065868209 @default.
• W2106610080 hasAuthorship W2106610080A5082034178 @default.
• W2106610080 hasBestOaLocation W21066100801 @default.
• W2106610080 hasConcept C1491633281 @default.
• W2106610080 hasConcept C16224149 @default.
• W2106610080 hasConcept C178790620 @default.
• W2106610080 hasConcept C185592680 @default.

• next