FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106649637> ?p ?o ?g. }

• W2106649637 endingPage "334" @default.
• W2106649637 startingPage "326" @default.
• W2106649637 abstract "We sought to determine which systolic blood pressure (SBP) characteristics are associated with reduced brain integrity and whether these associations are stronger for white or gray matter. We hypothesized that exposure to higher and variable SBP will be associated with lower structural integrity of both gray and white matter. Neuroimaging, SBP, and cognition were obtained in 311 community-dwelling adults in 2006–2008 (average age = 83 years; 58% women; 40% black). Antihypertensive medications, SBP, and health-related factors were collected from 1997 to 1998 to time of neuroimaging. SBP values obtained from 1997 to 1998 to time of neuroimaging were used to compute mean; pulse pressure; coefficient of variation; and peak, load, and group-based trajectories. Higher mean SBP was associated with lower white matter integrity in uncinate and superior lateral fasciculi bilaterally, independent of age, stroke history, antihypertensive medication use (odds ratio of having white matter hyperintensities greater than or equal to the median for 10mm Hg of SBP = 10.4, 95% confidence interval = 10.2–10.6, P = 0.0001; standardized beta for fractional anisotropy = −13.54, SE = 4.58, P = 0.003). These neuroimaging markers attenuated the association between higher SBP and lower digit symbol substitution test. Results were similar for trajectories of SBP and stronger for those with previously higher and variable SBP even if SBP was normal at neuroimaging. Results were similar for those without stroke. Associations with gray matter measures were not significant. If confirmed, these data suggest a history of higher and variable SBP for very old adults may be useful to alert clinicians to potential lower integrity in selected tracts, whereas cross-sectional SBP measurements may obscure the risk of underlying white matter hyperintensities. Whether lowering and/or stabilizing SBP levels in very old adults without a remarkable cardiovascular history would have neuroprotective effects and reduce dementia risk needs further study." @default.
• W2106649637 created "2016-06-24" @default.
• W2106649637 creator A5000985873 @default.
• W2106649637 creator A5005508214 @default.
• W2106649637 creator A5018378907 @default.
• W2106649637 creator A5022120351 @default.
• W2106649637 creator A5037369303 @default.
• W2106649637 creator A5055337948 @default.
• W2106649637 creator A5064816095 @default.
• W2106649637 creator A5078009095 @default.
• W2106649637 creator A5081107493 @default.
• W2106649637 creator A5087201620 @default.
• W2106649637 date "2014-08-26" @default.
• W2106649637 modified "2023-10-01" @default.
• W2106649637 title "Longitudinal Systolic Blood Pressure Characteristics and Integrity of White Matter Tracts in a Cohort of Very Old Black and White Adults" @default.
• W2106649637 cites W1519631919 @default.
• W2106649637 cites W1974466376 @default.
• W2106649637 cites W1976312033 @default.
• W2106649637 cites W1978799609 @default.
• W2106649637 cites W1984094638 @default.
• W2106649637 cites W1997140643 @default.
• W2106649637 cites W1997944093 @default.
• W2106649637 cites W1998387149 @default.
• W2106649637 cites W1999613587 @default.
• W2106649637 cites W2003191738 @default.
• W2106649637 cites W2003947229 @default.
• W2106649637 cites W2008273493 @default.
• W2106649637 cites W2009088633 @default.
• W2106649637 cites W2033143088 @default.
• W2106649637 cites W2041807904 @default.
• W2106649637 cites W2042497858 @default.
• W2106649637 cites W2048075564 @default.
• W2106649637 cites W2051052015 @default.
• W2106649637 cites W2057668022 @default.
• W2106649637 cites W2060153776 @default.
• W2106649637 cites W2061353398 @default.
• W2106649637 cites W2088396659 @default.
• W2106649637 cites W2088553046 @default.
• W2106649637 cites W2104192390 @default.
• W2106649637 cites W2104901197 @default.
• W2106649637 cites W2108451834 @default.
• W2106649637 cites W2108693233 @default.
• W2106649637 cites W2111662153 @default.
• W2106649637 cites W2118729903 @default.
• W2106649637 cites W2123174509 @default.
• W2106649637 cites W2126587429 @default.
• W2106649637 cites W2143620490 @default.
• W2106649637 cites W2156121263 @default.
• W2106649637 cites W2156574403 @default.
• W2106649637 cites W2159391588 @default.
• W2106649637 cites W2160643135 @default.
• W2106649637 cites W4319425452 @default.
• W2106649637 doi "https://doi.org/10.1093/ajh/hpu134" @default.
• W2106649637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4325666" @default.
• W2106649637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25159083" @default.
• W2106649637 hasPublicationYear "2014" @default.
• W2106649637 type Work @default.
• W2106649637 sameAs 2106649637 @default.
• W2106649637 citedByCount "38" @default.
• W2106649637 countsByYear W21066496372015 @default.
• W2106649637 countsByYear W21066496372016 @default.
• W2106649637 countsByYear W21066496372017 @default.
• W2106649637 countsByYear W21066496372018 @default.
• W2106649637 countsByYear W21066496372019 @default.
• W2106649637 countsByYear W21066496372020 @default.
• W2106649637 countsByYear W21066496372021 @default.
• W2106649637 countsByYear W21066496372022 @default.
• W2106649637 countsByYear W21066496372023 @default.
• W2106649637 crossrefType "journal-article" @default.
• W2106649637 hasAuthorship W2106649637A5000985873 @default.
• W2106649637 hasAuthorship W2106649637A5005508214 @default.
• W2106649637 hasAuthorship W2106649637A5018378907 @default.
• W2106649637 hasAuthorship W2106649637A5022120351 @default.
• W2106649637 hasAuthorship W2106649637A5037369303 @default.
• W2106649637 hasAuthorship W2106649637A5055337948 @default.
• W2106649637 hasAuthorship W2106649637A5064816095 @default.
• W2106649637 hasAuthorship W2106649637A5078009095 @default.
• W2106649637 hasAuthorship W2106649637A5081107493 @default.
• W2106649637 hasAuthorship W2106649637A5087201620 @default.
• W2106649637 hasBestOaLocation W21066496371 @default.
• W2106649637 hasConcept C118552586 @default.
• W2106649637 hasConcept C126322002 @default.
• W2106649637 hasConcept C126838900 @default.
• W2106649637 hasConcept C142724271 @default.
• W2106649637 hasConcept C143409427 @default.
• W2106649637 hasConcept C146638467 @default.
• W2106649637 hasConcept C156957248 @default.
• W2106649637 hasConcept C164705383 @default.
• W2106649637 hasConcept C17140001 @default.
• W2106649637 hasConcept C204787440 @default.
• W2106649637 hasConcept C27081682 @default.
• W2106649637 hasConcept C2776191500 @default.
• W2106649637 hasConcept C2777965283 @default.
• W2106649637 hasConcept C2778319312 @default.
• W2106649637 hasConcept C2781192897 @default.
• W2106649637 hasConcept C44249647 @default.
• W2106649637 hasConcept C58693492 @default.
• W2106649637 hasConcept C71924100 @default.

• next