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- W2106665982 abstract "A limited review of the changes in susceptibility of common bacterial pathogens to available antibacterial agents is presented. Significant developments in recent years include the following: (1) the emergence of Streptococcus pneumoniae with decreased resistance to penicillin and of some strains resistant to several antibiotics; (2) a decline in prevalence of multi-drug-resistant Staphylococcus aureus after 1960 following their increasing prevalence in the preceding years (these changes were associated with changes in phage types of the staphylococci); (3) the emergence of methicillin-resistant (and multi-drug-resistant) S. aureus and the marked differences in their prevalence in different areas' (these changes also were related to appearance of new phages in those organisms); (4) an increasing resistance to multiple drugs among enterococci but not among viridans streptococci or among nonenterococcal group D streptococci; (5) the emergence of β-lactamase-producing Neisseria gonorrhoeae; (6) the emergence and spread of sulfonamide-resistant Neisseria meningitidis; (7) the occurrence of β-lactamase-producing strains of Haemophilus infiuenzae and occasional strains resistant to chloramphenicol; (8) the focal occurrence of chloramphenicol- resistant Salmonella typhi in Vietnam and in epidemic form in Mexico; (9) the demonstration of marked differences in prevalence of resistance to multiple drugs in common pathogens to the most widely used antibiotics in different geographic areas. The dominant factor in the emergence and spread of antibiotic-resistant bacterial pathogens, whether in hospital wards or in the community, is clearly the intensive use of the antibiotic agents to which resistance emerges and then spreads." @default.
- W2106665982 created "2016-06-24" @default.
- W2106665982 creator A5044367072 @default.
- W2106665982 date "1979-01-01" @default.
- W2106665982 modified "2023-10-03" @default.
- W2106665982 title "Emergence of Antibiotic Resistance In Hospitals, 1935-1975" @default.
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- W2106665982 doi "https://doi.org/10.1093/clinids/1.1.4" @default.
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