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• W2106683287 abstract "Compelling evidence suggests that dietary intakes directly influence colorectal cancer (CRC) risk. Initial observations that CRC incidence is not ubiquitous worldwide, with incidence rates varying up to twenty-five fold between populations (Parkin et al., 2005), indicate the large degree to which this cancer type is influenced by diet and environment. Additionally, observations that migration of individuals confers rapid (within one generation) adoption of the CRC incidence of the host population (Boyle & Langman, 2000; McMichael & Giles, 1988), suggest that dietary and environmental factors determine the risk of colorectal neoplasia to a degree similar to, or in excess of, genetic predisposition. As diagnosis and treatment of CRC have improved, the study of the pathogenesis of colorectal neoplasia has increased. The most frequent precursor of CRC is the adenoma. As a proportion of adenomas, those of large size, with villous architecture and high grade dysplasia often progress to invasive adenocarcinoma, and this progression is associated with accumulation of mutations and other genetic and epigenetic changes. In the effort to understand the mechanisms and causes of colorectal cancer development, molecular genetic analyses have identified a variety of molecular changes and protein targets involved in colorectal tumourigenesis. The greater understanding of genetic, epigenetic and expression changes that occur during the development and progression of CRC has shown that these neoplasms do not comprise a single disease. Instead, colorectal cancers comprise a collection of distinct and independent neoplastic pathways, such as those pathways displaying chromosomal instability (CIN), microsatellite instability (MSI) or gene promoter activity changes due to the epigenetic phenomenon of methylation at CG dinucleotides (referred to as CIMP: CpG island methylation phenotype, whereby CpG describes dinoculeotides of cytosine and guanosine, separated by the characteristic phosphate group in the DNA structure). Each pathway subtype is characterised by individual genetic and molecular characteristics (Poulogiannis, 9" @default.
• W2106683287 created "2016-06-24" @default.
• W2106683287 creator A5019378167 @default.
• W2106683287 creator A5022615813 @default.
• W2106683287 creator A5075238158 @default.
• W2106683287 date "2012-02-17" @default.
• W2106683287 modified "2023-09-24" @default.
• W2106683287 title "The Molecular Genetic Events in Colorectal Cancer and Diet" @default.
• W2106683287 cites W123332762 @default.
• W2106683287 cites W1249487748 @default.
• W2106683287 cites W1494567425 @default.
• W2106683287 cites W15453418 @default.
• W2106683287 cites W1571302978 @default.
• W2106683287 cites W1594645437 @default.
• W2106683287 cites W1663072708 @default.
• W2106683287 cites W1867809475 @default.
• W2106683287 cites W1934558061 @default.
• W2106683287 cites W1939927669 @default.
• W2106683287 cites W1968331426 @default.
• W2106683287 cites W1975131304 @default.
• W2106683287 cites W1975224807 @default.
• W2106683287 cites W1977504138 @default.
• W2106683287 cites W1979921579 @default.
• W2106683287 cites W1984692429 @default.
• W2106683287 cites W1988699876 @default.
• W2106683287 cites W1988733824 @default.
• W2106683287 cites W1992251473 @default.
• W2106683287 cites W1994726657 @default.
• W2106683287 cites W1996926758 @default.
• W2106683287 cites W1997860952 @default.
• W2106683287 cites W2003930098 @default.
• W2106683287 cites W2006239354 @default.
• W2106683287 cites W2012504034 @default.
• W2106683287 cites W2019049058 @default.
• W2106683287 cites W2019527553 @default.
• W2106683287 cites W2020830322 @default.
• W2106683287 cites W2024508662 @default.
• W2106683287 cites W2026830194 @default.
• W2106683287 cites W2031113684 @default.
• W2106683287 cites W2031372290 @default.
• W2106683287 cites W2040524221 @default.
• W2106683287 cites W2040598241 @default.
• W2106683287 cites W2045184737 @default.
• W2106683287 cites W2045382071 @default.
• W2106683287 cites W2049958413 @default.
• W2106683287 cites W2059300459 @default.
• W2106683287 cites W2059468777 @default.
• W2106683287 cites W2061812574 @default.
• W2106683287 cites W2067126050 @default.
• W2106683287 cites W2070107838 @default.
• W2106683287 cites W2071057974 @default.
• W2106683287 cites W2075104267 @default.
• W2106683287 cites W2078158452 @default.
• W2106683287 cites W2079577516 @default.
• W2106683287 cites W2081986214 @default.
• W2106683287 cites W2082040301 @default.
• W2106683287 cites W2082522931 @default.
• W2106683287 cites W2092051671 @default.
• W2106683287 cites W2093531978 @default.
• W2106683287 cites W2093550207 @default.
• W2106683287 cites W2093947855 @default.
• W2106683287 cites W2098737540 @default.
• W2106683287 cites W2100545040 @default.
• W2106683287 cites W2103104055 @default.
• W2106683287 cites W2106787323 @default.
• W2106683287 cites W2107972234 @default.
• W2106683287 cites W2111044431 @default.
• W2106683287 cites W2112698732 @default.
• W2106683287 cites W2118049070 @default.
• W2106683287 cites W2119806015 @default.
• W2106683287 cites W2119903193 @default.
• W2106683287 cites W2120099188 @default.
• W2106683287 cites W2122304368 @default.
• W2106683287 cites W2123702717 @default.
• W2106683287 cites W2125957956 @default.
• W2106683287 cites W2128146359 @default.
• W2106683287 cites W2128337419 @default.
• W2106683287 cites W2132758631 @default.
• W2106683287 cites W2133374268 @default.
• W2106683287 cites W2136047825 @default.
• W2106683287 cites W2137121734 @default.
• W2106683287 cites W2144346470 @default.
• W2106683287 cites W2148346218 @default.
• W2106683287 cites W2148461273 @default.
• W2106683287 cites W2156286678 @default.
• W2106683287 cites W2159594827 @default.
• W2106683287 cites W2159657430 @default.
• W2106683287 cites W2163295338 @default.
• W2106683287 cites W2167109216 @default.
• W2106683287 cites W2167370693 @default.
• W2106683287 cites W2167723186 @default.
• W2106683287 cites W2168435292 @default.
• W2106683287 cites W2169284074 @default.
• W2106683287 cites W2169560879 @default.
• W2106683287 cites W2181485293 @default.
• W2106683287 cites W2182109552 @default.
• W2106683287 cites W2186027080 @default.
• W2106683287 cites W2186839178 @default.
• W2106683287 cites W2187938013 @default.
• W2106683287 cites W632350707 @default.

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