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- W2106684311 abstract "Nitric oxide (NO·) is an important mediator of innate immunity. The facultative intracellular pathogen Salmonella has evolved mechanisms to detoxify and evade the antimicrobial actions of host-derived NO· produced during infection. Expression of the NO·-detoxifying flavohaemoglobin Hmp is controlled by the NO·-sensing transcriptional repressor NsrR and is required for Salmonella virulence. In this study we show that NsrR responds to very low NO· concentrations, suggesting that it plays a primary role in the nitrosative stress response. Additionally, we have defined the NsrR regulon in Salmonella enterica sv. Typhimurium 14028s using transcriptional microarray, qRT-PCR and in silico methods. A novel NsrR-regulated gene designated STM1808 has been identified, along with hmp, hcp-hcr, yeaR-yoaG, ygbA and ytfE. STM1808 and ygbA are important for S. Typhimurium growth during nitrosative stress, and the hcp-hcr locus plays a supportive role in NO· detoxification. ICP-MS analysis of purified STM1808 suggests that it is a zinc metalloprotein, with histidine residues H32 and H82 required for NO· resistance and zinc binding. Moreover, STM1808 and ytfE promote Salmonella growth during systemic infection of mice. Collectively, these findings demonstrate that NsrR-regulated genes in addition to hmp are important for NO· detoxification, nitrosative stress resistance and Salmonella virulence." @default.
- W2106684311 created "2016-06-24" @default.
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- W2106684311 date "2012-07-25" @default.
- W2106684311 modified "2023-10-02" @default.
- W2106684311 title "The NsrR regulon in nitrosative stress resistance of<i>Salmonella enterica</i>serovar Typhimurium" @default.
- W2106684311 cites W1692427743 @default.
- W2106684311 cites W1875420487 @default.
- W2106684311 cites W1962419639 @default.
- W2106684311 cites W1965416085 @default.
- W2106684311 cites W1965481505 @default.
- W2106684311 cites W1966350980 @default.
- W2106684311 cites W1966517868 @default.
- W2106684311 cites W1976321043 @default.
- W2106684311 cites W1998514973 @default.
- W2106684311 cites W2000547013 @default.
- W2106684311 cites W2011885345 @default.
- W2106684311 cites W2018862405 @default.
- W2106684311 cites W2028734313 @default.
- W2106684311 cites W2028775627 @default.
- W2106684311 cites W2030076441 @default.
- W2106684311 cites W2034091834 @default.
- W2106684311 cites W2036094503 @default.
- W2106684311 cites W2036943901 @default.
- W2106684311 cites W2037993016 @default.
- W2106684311 cites W2038065826 @default.
- W2106684311 cites W2040279930 @default.
- W2106684311 cites W2042245200 @default.
- W2106684311 cites W2042856376 @default.
- W2106684311 cites W2044280081 @default.
- W2106684311 cites W2044743938 @default.
- W2106684311 cites W2049595568 @default.
- W2106684311 cites W2057015493 @default.
- W2106684311 cites W2059005698 @default.
- W2106684311 cites W2060178110 @default.
- W2106684311 cites W2060449083 @default.
- W2106684311 cites W2061810783 @default.
- W2106684311 cites W2062201776 @default.
- W2106684311 cites W2064567333 @default.
- W2106684311 cites W2064775719 @default.
- W2106684311 cites W2066515050 @default.
- W2106684311 cites W2066916734 @default.
- W2106684311 cites W2069848230 @default.
- W2106684311 cites W2071809778 @default.
- W2106684311 cites W2074335496 @default.
- W2106684311 cites W2076864884 @default.
- W2106684311 cites W2077788018 @default.
- W2106684311 cites W2081226705 @default.
- W2106684311 cites W2085551318 @default.
- W2106684311 cites W2090383135 @default.
- W2106684311 cites W2091043643 @default.
- W2106684311 cites W2092298652 @default.
- W2106684311 cites W2093427530 @default.
- W2106684311 cites W2093487718 @default.
- W2106684311 cites W2094406540 @default.
- W2106684311 cites W2097922773 @default.
- W2106684311 cites W2101157833 @default.
- W2106684311 cites W2102601193 @default.
- W2106684311 cites W2104256179 @default.
- W2106684311 cites W2106873948 @default.
- W2106684311 cites W2106882534 @default.
- W2106684311 cites W2109591731 @default.
- W2106684311 cites W2111984347 @default.
- W2106684311 cites W2114247539 @default.
- W2106684311 cites W2116137883 @default.
- W2106684311 cites W2116200300 @default.
- W2106684311 cites W2116502180 @default.
- W2106684311 cites W2116890727 @default.
- W2106684311 cites W2118172035 @default.
- W2106684311 cites W2119926275 @default.
- W2106684311 cites W2120926466 @default.
- W2106684311 cites W2123340625 @default.
- W2106684311 cites W2124345503 @default.
- W2106684311 cites W2125021980 @default.
- W2106684311 cites W2125489894 @default.
- W2106684311 cites W2126551065 @default.
- W2106684311 cites W2127289590 @default.
- W2106684311 cites W2127321094 @default.
- W2106684311 cites W2131510173 @default.
- W2106684311 cites W2132644071 @default.
- W2106684311 cites W2135004245 @default.
- W2106684311 cites W2137285295 @default.
- W2106684311 cites W2138298422 @default.
- W2106684311 cites W2140088249 @default.
- W2106684311 cites W2141480758 @default.
- W2106684311 cites W2141518235 @default.
- W2106684311 cites W2146771855 @default.
- W2106684311 cites W2155331964 @default.
- W2106684311 cites W2158718811 @default.