FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106698339> ?p ?o ?g. }

• W2106698339 endingPage "S367" @default.
• W2106698339 startingPage "S359" @default.
• W2106698339 abstract "Background. Throughout the 2014–2015 Ebola outbreak in West Africa, major gaps were exposed in the availability of validated rapid diagnostic platforms, protective vaccines, and effective therapeutic agents. These gaps potentiated the development of prototype rapid lateral flow immunodiagnostic (LFI) assays that are true point-of-contact platforms, for the detection of active Ebola infections in small blood samples. Methods. Recombinant Ebola and Marburg virus matrix VP40 and glycoprotein (GP) antigens were used to derive a panel of monoclonal and polyclonal antibodies. Antibodies were tested using a multivariate approach to identify antibody-antigen combinations suitable for enzyme-linked immunosorbent assay (ELISA) and LFI assay development. Results. Polyclonal antibodies generated in goats were superior reagents for capture and detection of recombinant VP40 in test sample matrices. These antibodies were optimized for use in antigen-capture ELISA and LFI assay platforms. Prototype immunoglobulin M (IgM)/immunoglobulin G (IgG) ELISAs were similarly developed that specifically detect Ebola virus–specific antibodies in the serum of experimentally infected nonhuman primates and in blood samples obtained from patients with Ebola from Sierra Leone. Conclusions. The prototype recombinant Ebola LFI assays developed in these studies have sensitivities that are useful for clinical diagnosis of acute ebolavirus infections. The antigen-capture and IgM/IgG ELISAs provide additional confirmatory assay platforms for detecting VP40 and other ebolavirus-specific immunoglobulins." @default.
• W2106698339 created "2016-06-24" @default.
• W2106698339 creator A5002841632 @default.
• W2106698339 creator A5003322592 @default.
• W2106698339 creator A5004934227 @default.
• W2106698339 creator A5007663894 @default.
• W2106698339 creator A5007787567 @default.
• W2106698339 creator A5010734651 @default.
• W2106698339 creator A5011427246 @default.
• W2106698339 creator A5013920926 @default.
• W2106698339 creator A5014961957 @default.
• W2106698339 creator A5016090653 @default.
• W2106698339 creator A5018154765 @default.
• W2106698339 creator A5019746739 @default.
• W2106698339 creator A5020131609 @default.
• W2106698339 creator A5027350778 @default.
• W2106698339 creator A5028965493 @default.
• W2106698339 creator A5031332045 @default.
• W2106698339 creator A5033058391 @default.
• W2106698339 creator A5035132333 @default.
• W2106698339 creator A5036116217 @default.
• W2106698339 creator A5037146272 @default.
• W2106698339 creator A5039574825 @default.
• W2106698339 creator A5040099035 @default.
• W2106698339 creator A5042794716 @default.
• W2106698339 creator A5045480900 @default.
• W2106698339 creator A5046619726 @default.
• W2106698339 creator A5050377255 @default.
• W2106698339 creator A5052279663 @default.
• W2106698339 creator A5061065988 @default.
• W2106698339 creator A5061799594 @default.
• W2106698339 creator A5064475612 @default.
• W2106698339 creator A5066778957 @default.
• W2106698339 creator A5069598938 @default.
• W2106698339 creator A5078729236 @default.
• W2106698339 creator A5079001179 @default.
• W2106698339 date "2015-07-30" @default.
• W2106698339 modified "2023-10-15" @default.
• W2106698339 title "Development of Prototype Filovirus Recombinant Antigen Immunoassays" @default.
• W2106698339 cites W1853748609 @default.
• W2106698339 cites W1973436585 @default.
• W2106698339 cites W1975375203 @default.
• W2106698339 cites W1979071280 @default.
• W2106698339 cites W1988879898 @default.
• W2106698339 cites W2012416948 @default.
• W2106698339 cites W2013622916 @default.
• W2106698339 cites W2018986816 @default.
• W2106698339 cites W2033604009 @default.
• W2106698339 cites W2043670145 @default.
• W2106698339 cites W2093662506 @default.
• W2106698339 cites W2094644220 @default.
• W2106698339 cites W2102270811 @default.
• W2106698339 cites W2112956516 @default.
• W2106698339 cites W2115102869 @default.
• W2106698339 cites W2128963410 @default.
• W2106698339 cites W2129823003 @default.
• W2106698339 cites W2136802150 @default.
• W2106698339 cites W2138040946 @default.
• W2106698339 cites W2138251901 @default.
• W2106698339 cites W2138741496 @default.
• W2106698339 cites W2143320796 @default.
• W2106698339 cites W2155545597 @default.
• W2106698339 cites W2161510767 @default.
• W2106698339 cites W2162730915 @default.
• W2106698339 cites W4210722842 @default.
• W2106698339 doi "https://doi.org/10.1093/infdis/jiv353" @default.
• W2106698339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4564556" @default.
• W2106698339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26232440" @default.
• W2106698339 hasPublicationYear "2015" @default.
• W2106698339 type Work @default.
• W2106698339 sameAs 2106698339 @default.
• W2106698339 citedByCount "29" @default.
• W2106698339 countsByYear W21066983392016 @default.
• W2106698339 countsByYear W21066983392017 @default.
• W2106698339 countsByYear W21066983392018 @default.
• W2106698339 countsByYear W21066983392019 @default.
• W2106698339 countsByYear W21066983392020 @default.
• W2106698339 countsByYear W21066983392021 @default.
• W2106698339 countsByYear W21066983392022 @default.
• W2106698339 countsByYear W21066983392023 @default.
• W2106698339 crossrefType "journal-article" @default.
• W2106698339 hasAuthorship W2106698339A5002841632 @default.
• W2106698339 hasAuthorship W2106698339A5003322592 @default.
• W2106698339 hasAuthorship W2106698339A5004934227 @default.
• W2106698339 hasAuthorship W2106698339A5007663894 @default.
• W2106698339 hasAuthorship W2106698339A5007787567 @default.
• W2106698339 hasAuthorship W2106698339A5010734651 @default.
• W2106698339 hasAuthorship W2106698339A5011427246 @default.
• W2106698339 hasAuthorship W2106698339A5013920926 @default.
• W2106698339 hasAuthorship W2106698339A5014961957 @default.
• W2106698339 hasAuthorship W2106698339A5016090653 @default.
• W2106698339 hasAuthorship W2106698339A5018154765 @default.
• W2106698339 hasAuthorship W2106698339A5019746739 @default.
• W2106698339 hasAuthorship W2106698339A5020131609 @default.
• W2106698339 hasAuthorship W2106698339A5027350778 @default.
• W2106698339 hasAuthorship W2106698339A5028965493 @default.
• W2106698339 hasAuthorship W2106698339A5031332045 @default.
• W2106698339 hasAuthorship W2106698339A5033058391 @default.

• next