FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106732518> ?p ?o ?g. }

• W2106732518 abstract "Ethylmalonic acid (EMA) accumulates in tissues of patients affected by short-chain acyl-CoA dehydrogenase deficiency and ethylmalonic encephalopathy, illnesses characterized by variable neurological symptoms. In this work, we investigated the in vitro and in vivo EMA effects on Na(+), K(+)-ATPase (NAK) activity and mRNA levels in cerebral cortex from 30-day-old rats. For in vitro studies, cerebral cortex homogenates were incubated in the presence of EMA at 0.5, 1, or 2.5 mM concentrations for 1 h. For in vivo experiments, animals received three subcutaneous EMA injections (6 μmol g(-1); 90-min interval) and were killed 60 min after the last injection. After that, NAK activity and its mRNA expression were measured. We observed that EMA did not affect this enzyme activity in vitro. In contrast, EMA administration significantly increased NAK activity and decreased mRNA NAK expression as assessed by semiquantitative reverse transcriptase polymerase chain reaction when compared with control group. Considering the high score of residues prone to phosphorylation on NAK, this profile can be associated with a possible regulation by specific phosphorylation sites of the enzyme. Altogether, the present results suggest that NAK alterations may be involved in the pathophysiology of brain damage found in patients in which EMA accumulates." @default.
• W2106732518 created "2016-06-24" @default.
• W2106732518 creator A5005447472 @default.
• W2106732518 creator A5008213735 @default.
• W2106732518 creator A5012485536 @default.
• W2106732518 creator A5021019594 @default.
• W2106732518 creator A5040779314 @default.
• W2106732518 creator A5062953785 @default.
• W2106732518 creator A5063336320 @default.
• W2106732518 creator A5074300707 @default.
• W2106732518 creator A5082443419 @default.
• W2106732518 date "2012-12-06" @default.
• W2106732518 modified "2023-10-11" @default.
• W2106732518 title "Ethylmalonic acid modulates Na+, K+-ATPase activity and mRNA levels in rat cerebral cortex" @default.
• W2106732518 cites W1897509355 @default.
• W2106732518 cites W1973981787 @default.
• W2106732518 cites W1977195428 @default.
• W2106732518 cites W1991457983 @default.
• W2106732518 cites W1999964851 @default.
• W2106732518 cites W2001552323 @default.
• W2106732518 cites W2002775774 @default.
• W2106732518 cites W2005329067 @default.
• W2106732518 cites W2012910563 @default.
• W2106732518 cites W2018207804 @default.
• W2106732518 cites W2026979523 @default.
• W2106732518 cites W2034723794 @default.
• W2106732518 cites W2040838847 @default.
• W2106732518 cites W2050618517 @default.
• W2106732518 cites W2059845673 @default.
• W2106732518 cites W2060734341 @default.
• W2106732518 cites W2064171871 @default.
• W2106732518 cites W2064454966 @default.
• W2106732518 cites W2070031024 @default.
• W2106732518 cites W2072153636 @default.
• W2106732518 cites W2074276447 @default.
• W2106732518 cites W2081335102 @default.
• W2106732518 cites W2082539152 @default.
• W2106732518 cites W2086359390 @default.
• W2106732518 cites W2093772131 @default.
• W2106732518 cites W2097885553 @default.
• W2106732518 cites W2108078368 @default.
• W2106732518 cites W2109623522 @default.
• W2106732518 cites W2116056812 @default.
• W2106732518 cites W2123274056 @default.
• W2106732518 cites W2123702622 @default.
• W2106732518 cites W2134094421 @default.
• W2106732518 cites W2140597534 @default.
• W2106732518 cites W2146020890 @default.
• W2106732518 cites W2154199509 @default.
• W2106732518 cites W2163616625 @default.
• W2106732518 cites W2164154480 @default.
• W2106732518 cites W2315032105 @default.
• W2106732518 cites W268715191 @default.
• W2106732518 cites W274108598 @default.
• W2106732518 cites W302123003 @default.
• W2106732518 cites W4235213316 @default.
• W2106732518 cites W4293247451 @default.
• W2106732518 doi "https://doi.org/10.1002/syn.21618" @default.
• W2106732518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23161776" @default.
• W2106732518 hasPublicationYear "2012" @default.
• W2106732518 type Work @default.
• W2106732518 sameAs 2106732518 @default.
• W2106732518 citedByCount "5" @default.
• W2106732518 countsByYear W21067325182013 @default.
• W2106732518 countsByYear W21067325182014 @default.
• W2106732518 countsByYear W21067325182015 @default.
• W2106732518 crossrefType "journal-article" @default.
• W2106732518 hasAuthorship W2106732518A5005447472 @default.
• W2106732518 hasAuthorship W2106732518A5008213735 @default.
• W2106732518 hasAuthorship W2106732518A5012485536 @default.
• W2106732518 hasAuthorship W2106732518A5021019594 @default.
• W2106732518 hasAuthorship W2106732518A5040779314 @default.
• W2106732518 hasAuthorship W2106732518A5062953785 @default.
• W2106732518 hasAuthorship W2106732518A5063336320 @default.
• W2106732518 hasAuthorship W2106732518A5074300707 @default.
• W2106732518 hasAuthorship W2106732518A5082443419 @default.
• W2106732518 hasConcept C10162356 @default.
• W2106732518 hasConcept C104317684 @default.
• W2106732518 hasConcept C105580179 @default.
• W2106732518 hasConcept C126322002 @default.
• W2106732518 hasConcept C134018914 @default.
• W2106732518 hasConcept C150903083 @default.
• W2106732518 hasConcept C169760540 @default.
• W2106732518 hasConcept C181199279 @default.
• W2106732518 hasConcept C185592680 @default.
• W2106732518 hasConcept C202751555 @default.
• W2106732518 hasConcept C207001950 @default.
• W2106732518 hasConcept C2777348757 @default.
• W2106732518 hasConcept C2781041448 @default.
• W2106732518 hasConcept C28212737 @default.
• W2106732518 hasConcept C55493867 @default.
• W2106732518 hasConcept C71924100 @default.
• W2106732518 hasConcept C86803240 @default.
• W2106732518 hasConceptScore W2106732518C10162356 @default.
• W2106732518 hasConceptScore W2106732518C104317684 @default.
• W2106732518 hasConceptScore W2106732518C105580179 @default.
• W2106732518 hasConceptScore W2106732518C126322002 @default.
• W2106732518 hasConceptScore W2106732518C134018914 @default.
• W2106732518 hasConceptScore W2106732518C150903083 @default.
• W2106732518 hasConceptScore W2106732518C169760540 @default.

• next