FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106746809> ?p ?o ?g. }

• W2106746809 endingPage "3146" @default.
• W2106746809 startingPage "3141" @default.
• W2106746809 abstract "Dithranol is enormously effective in the treatment of psoriasis; however its molecular mode of action should be further elucidated. Since epidermal growth factor receptor (EGFR) is involved in the pathogenesis of psoriasis, the objective of this study was to investigate the transcriptional effect of dithranol on EGFR gene expression in the HaCaT keratinocyte cell line, which is commonly employed as a model system to study psoriasis including experiments examining the effects of therapeutic drugs and cellular regulators on keratinocytes. Cultured HaCaT cells were treated with 0.1-0.5 ig/ml dithranol for 30 min. After 4 h, total cellular RNA isolated from HaCaT cells was reverse transcribed to cDNA which was subjected to polymerase chain reaction (PCR) with specific primer pair for EGFR. We found that dithranol treatment down-regulated the EGFR mRNA of HaCaT cells in a concentration-dependent manner. Our result was further substantiated using a quantitative real-time PCR approach. Taken together, the dithranol-induced down-regulation of the EGFR in cultured human keratinocytes might help to disclose the molecular therapeutic action of the drug." @default.
• W2106746809 created "2016-06-24" @default.
• W2106746809 creator A5025371447 @default.
• W2106746809 creator A5079500426 @default.
• W2106746809 creator A5091263876 @default.
• W2106746809 creator A5091738492 @default.
• W2106746809 date "2009-07-20" @default.
• W2106746809 modified "2023-09-22" @default.
• W2106746809 title "Decreased EGFR mRNA expression in response to antipsoriatic drug dithranol in vitro" @default.
• W2106746809 cites W139613233 @default.
• W2106746809 cites W1519196356 @default.
• W2106746809 cites W1890532746 @default.
• W2106746809 cites W1968372696 @default.
• W2106746809 cites W1981474045 @default.
• W2106746809 cites W1987212762 @default.
• W2106746809 cites W2000051219 @default.
• W2106746809 cites W2009880957 @default.
• W2106746809 cites W2010696261 @default.
• W2106746809 cites W2011253397 @default.
• W2106746809 cites W2013497532 @default.
• W2106746809 cites W2024529411 @default.
• W2106746809 cites W2027008562 @default.
• W2106746809 cites W2045563801 @default.
• W2106746809 cites W2066104914 @default.
• W2106746809 cites W2072133488 @default.
• W2106746809 cites W2082289095 @default.
• W2106746809 cites W2085776873 @default.
• W2106746809 cites W2088616738 @default.
• W2106746809 cites W2089994718 @default.
• W2106746809 cites W2108244474 @default.
• W2106746809 cites W2125371725 @default.
• W2106746809 cites W2132652347 @default.
• W2106746809 cites W2143464311 @default.
• W2106746809 cites W2150811777 @default.
• W2106746809 cites W2158293853 @default.
• W2106746809 cites W2166817851 @default.
• W2106746809 cites W2167242172 @default.
• W2106746809 cites W2169012204 @default.
• W2106746809 cites W2328687205 @default.
• W2106746809 cites W2410610168 @default.
• W2106746809 doi "https://doi.org/10.5897/ajb09.125" @default.
• W2106746809 hasPublicationYear "2009" @default.
• W2106746809 type Work @default.
• W2106746809 sameAs 2106746809 @default.
• W2106746809 citedByCount "1" @default.
• W2106746809 countsByYear W21067468092012 @default.
• W2106746809 crossrefType "journal-article" @default.
• W2106746809 hasAuthorship W2106746809A5025371447 @default.
• W2106746809 hasAuthorship W2106746809A5079500426 @default.
• W2106746809 hasAuthorship W2106746809A5091263876 @default.
• W2106746809 hasAuthorship W2106746809A5091738492 @default.
• W2106746809 hasConcept C104317684 @default.
• W2106746809 hasConcept C105580179 @default.
• W2106746809 hasConcept C118995209 @default.
• W2106746809 hasConcept C121587506 @default.
• W2106746809 hasConcept C153911025 @default.
• W2106746809 hasConcept C185592680 @default.
• W2106746809 hasConcept C202751555 @default.
• W2106746809 hasConcept C203014093 @default.
• W2106746809 hasConcept C2777074287 @default.
• W2106746809 hasConcept C2780564577 @default.
• W2106746809 hasConcept C2781463552 @default.
• W2106746809 hasConcept C48023723 @default.
• W2106746809 hasConcept C502942594 @default.
• W2106746809 hasConcept C54355233 @default.
• W2106746809 hasConcept C55493867 @default.
• W2106746809 hasConcept C81885089 @default.
• W2106746809 hasConcept C86803240 @default.
• W2106746809 hasConcept C98274493 @default.
• W2106746809 hasConceptScore W2106746809C104317684 @default.
• W2106746809 hasConceptScore W2106746809C105580179 @default.
• W2106746809 hasConceptScore W2106746809C118995209 @default.
• W2106746809 hasConceptScore W2106746809C121587506 @default.
• W2106746809 hasConceptScore W2106746809C153911025 @default.
• W2106746809 hasConceptScore W2106746809C185592680 @default.
• W2106746809 hasConceptScore W2106746809C202751555 @default.
• W2106746809 hasConceptScore W2106746809C203014093 @default.
• W2106746809 hasConceptScore W2106746809C2777074287 @default.
• W2106746809 hasConceptScore W2106746809C2780564577 @default.
• W2106746809 hasConceptScore W2106746809C2781463552 @default.
• W2106746809 hasConceptScore W2106746809C48023723 @default.
• W2106746809 hasConceptScore W2106746809C502942594 @default.
• W2106746809 hasConceptScore W2106746809C54355233 @default.
• W2106746809 hasConceptScore W2106746809C55493867 @default.
• W2106746809 hasConceptScore W2106746809C81885089 @default.
• W2106746809 hasConceptScore W2106746809C86803240 @default.
• W2106746809 hasConceptScore W2106746809C98274493 @default.
• W2106746809 hasIssue "14" @default.
• W2106746809 hasLocation W21067468091 @default.
• W2106746809 hasOpenAccess W2106746809 @default.
• W2106746809 hasPrimaryLocation W21067468091 @default.
• W2106746809 hasRelatedWork W145050271 @default.
• W2106746809 hasRelatedWork W1594493125 @default.
• W2106746809 hasRelatedWork W1920919862 @default.
• W2106746809 hasRelatedWork W1973621648 @default.
• W2106746809 hasRelatedWork W1987408667 @default.
• W2106746809 hasRelatedWork W1988808169 @default.
• W2106746809 hasRelatedWork W2015878053 @default.

• next