FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106758148> ?p ?o ?g. }

• W2106758148 endingPage "2252" @default.
• W2106758148 startingPage "2245" @default.
• W2106758148 abstract "Pharmacokinetic and coagulation studies were carried out over a 12-week period with 11 asymptomatic hemophilia patients with human immunodeficiency virus infection receiving zidovudine (ZDV). The patients received 300 mg every 4 h while awake (the accepted dose at the time of this study); consecutive 24-h intravenous (i.v.) and 12-h oral pharmacokinetic studies were conducted at weeks 1, 6, and 12. Coagulation studies were conducted at weeks 0, 4, 8, and 12. The numbers of units of factors VIII and IX and cryoprecipitate transfused during the 12-week periods before, during, and after ZDV treatment were recorded. Following i.v. and oral ZDV administration, the concentration in plasma declined rapidly over the first 4 h, and in some patients, ZDV was still detectable at 4 to 10 h. The i.v. total clearances (means +/- standard deviations) were 14.9 +/- 7.3, 11.2 +/- 3.7, and 15.1 +/- 4.7 ml/min/kg of body weight. The i.v. distribution volumes were 1.08 +/- 0.5, 1.0 +/- 0.4, and 1.65 +/- 1.4 liters/kg. The bioavailabilities were 0.54 +/- 0.22, 0.46 +/- 0.19, and 0.59 +/- 0.13 at weeks 1, 6, and 12, respectively. The pattern of ZDV-glucuronide (GZDV) disposition was similar to that of ZDV, and the peak plasma GZDV-to-ZDV ratio was higher after oral dosing, consistent with first-pass metabolism. In some individuals, up to 33% of an i.v. dose was excreted unchanged. At weeks 6 and 12, greater than 300 mg of total ZDV (GZDV plus ZDV) was recovered in the urine of some patients, suggesting tissue redistribution. Concentration in plasma after oral ZDV administration were variable, both within and between patients. The von Willebrand antigen level consistently decreased throughout the study but was not accompanied by a parallel change in ristocetin cofactor A activity, and no clinical adverse effects on coagulation were noted. This study demonstrates that ZDV can be used in hemophilia patients without worsening of their bleeding tendencies. The clinical significance of decreased ZDV clearance and the prolonged terminal elimination phase of ZDV will require further study with patients receiving chronic ZDV." @default.
• W2106758148 created "2016-06-24" @default.
• W2106758148 creator A5027844742 @default.
• W2106758148 creator A5032948379 @default.
• W2106758148 creator A5036045574 @default.
• W2106758148 creator A5040054103 @default.
• W2106758148 creator A5048278356 @default.
• W2106758148 creator A5070326773 @default.
• W2106758148 creator A5080060583 @default.
• W2106758148 creator A5091635479 @default.
• W2106758148 date "1992-10-01" @default.
• W2106758148 modified "2023-09-26" @default.
• W2106758148 title "Intravenous and oral zidovudine pharmacokinetics and coagulation effects in asymptomatic human immunodeficiency virus-infected hemophilia patients" @default.
• W2106758148 cites W1969342428 @default.
• W2106758148 cites W1979300114 @default.
• W2106758148 cites W1986781835 @default.
• W2106758148 cites W2015284136 @default.
• W2106758148 cites W2032950527 @default.
• W2106758148 cites W2046294366 @default.
• W2106758148 cites W2070080098 @default.
• W2106758148 cites W2080314044 @default.
• W2106758148 cites W2087293479 @default.
• W2106758148 cites W2090450557 @default.
• W2106758148 cites W2094562745 @default.
• W2106758148 cites W2133012511 @default.
• W2106758148 cites W2160871721 @default.
• W2106758148 cites W2168401405 @default.
• W2106758148 cites W2311766294 @default.
• W2106758148 cites W2335635743 @default.
• W2106758148 cites W2411509899 @default.
• W2106758148 cites W264474996 @default.
• W2106758148 cites W4232251847 @default.
• W2106758148 cites W4256221661 @default.
• W2106758148 cites W4299342770 @default.
• W2106758148 doi "https://doi.org/10.1128/aac.36.10.2245" @default.
• W2106758148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/245484" @default.
• W2106758148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1444306" @default.
• W2106758148 hasPublicationYear "1992" @default.
• W2106758148 type Work @default.
• W2106758148 sameAs 2106758148 @default.
• W2106758148 citedByCount "12" @default.
• W2106758148 crossrefType "journal-article" @default.
• W2106758148 hasAuthorship W2106758148A5027844742 @default.
• W2106758148 hasAuthorship W2106758148A5032948379 @default.
• W2106758148 hasAuthorship W2106758148A5036045574 @default.
• W2106758148 hasAuthorship W2106758148A5040054103 @default.
• W2106758148 hasAuthorship W2106758148A5048278356 @default.
• W2106758148 hasAuthorship W2106758148A5070326773 @default.
• W2106758148 hasAuthorship W2106758148A5080060583 @default.
• W2106758148 hasAuthorship W2106758148A5091635479 @default.
• W2106758148 hasBestOaLocation W21067581481 @default.
• W2106758148 hasConcept C112705442 @default.
• W2106758148 hasConcept C126322002 @default.
• W2106758148 hasConcept C159047783 @default.
• W2106758148 hasConcept C2777056448 @default.
• W2106758148 hasConcept C2777288759 @default.
• W2106758148 hasConcept C2777910003 @default.
• W2106758148 hasConcept C2778258694 @default.
• W2106758148 hasConcept C2780216070 @default.
• W2106758148 hasConcept C2780727368 @default.
• W2106758148 hasConcept C3013748606 @default.
• W2106758148 hasConcept C71924100 @default.
• W2106758148 hasConcept C89560881 @default.
• W2106758148 hasConcept C90924648 @default.
• W2106758148 hasConcept C98274493 @default.
• W2106758148 hasConceptScore W2106758148C112705442 @default.
• W2106758148 hasConceptScore W2106758148C126322002 @default.
• W2106758148 hasConceptScore W2106758148C159047783 @default.
• W2106758148 hasConceptScore W2106758148C2777056448 @default.
• W2106758148 hasConceptScore W2106758148C2777288759 @default.
• W2106758148 hasConceptScore W2106758148C2777910003 @default.
• W2106758148 hasConceptScore W2106758148C2778258694 @default.
• W2106758148 hasConceptScore W2106758148C2780216070 @default.
• W2106758148 hasConceptScore W2106758148C2780727368 @default.
• W2106758148 hasConceptScore W2106758148C3013748606 @default.
• W2106758148 hasConceptScore W2106758148C71924100 @default.
• W2106758148 hasConceptScore W2106758148C89560881 @default.
• W2106758148 hasConceptScore W2106758148C90924648 @default.
• W2106758148 hasConceptScore W2106758148C98274493 @default.
• W2106758148 hasIssue "10" @default.
• W2106758148 hasLocation W21067581481 @default.
• W2106758148 hasLocation W21067581482 @default.
• W2106758148 hasLocation W21067581483 @default.
• W2106758148 hasOpenAccess W2106758148 @default.
• W2106758148 hasPrimaryLocation W21067581481 @default.
• W2106758148 hasRelatedWork W1986143785 @default.
• W2106758148 hasRelatedWork W2004325424 @default.
• W2106758148 hasRelatedWork W2009820498 @default.
• W2106758148 hasRelatedWork W2040713682 @default.
• W2106758148 hasRelatedWork W2073226188 @default.
• W2106758148 hasRelatedWork W2125636877 @default.
• W2106758148 hasRelatedWork W2435989539 @default.
• W2106758148 hasRelatedWork W2793520024 @default.
• W2106758148 hasRelatedWork W3021369409 @default.
• W2106758148 hasRelatedWork W3198826726 @default.
• W2106758148 hasVolume "36" @default.
• W2106758148 isParatext "false" @default.
• W2106758148 isRetracted "false" @default.

• next