Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106779017> ?p ?o ?g. }
- W2106779017 endingPage "1125" @default.
- W2106779017 startingPage "1118" @default.
- W2106779017 abstract "Miles Parkes and colleagues report results of a large genome-wide association meta-analysis and replication study for Crohn's disease. They identify 30 new susceptibility loci for this inflammatory bowel disease and implicate several interesting candidate genes in disease pathogenesis. We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10−8). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease." @default.
- W2106779017 created "2016-06-24" @default.
- W2106779017 creator A5002508254 @default.
- W2106779017 creator A5003048730 @default.
- W2106779017 creator A5004929872 @default.
- W2106779017 creator A5005142341 @default.
- W2106779017 creator A5006016461 @default.
- W2106779017 creator A5006070385 @default.
- W2106779017 creator A5006249166 @default.
- W2106779017 creator A5009290511 @default.
- W2106779017 creator A5009681341 @default.
- W2106779017 creator A5011577547 @default.
- W2106779017 creator A5012331187 @default.
- W2106779017 creator A5012477767 @default.
- W2106779017 creator A5012807902 @default.
- W2106779017 creator A5016660514 @default.
- W2106779017 creator A5017628987 @default.
- W2106779017 creator A5018576704 @default.
- W2106779017 creator A5018605111 @default.
- W2106779017 creator A5019474609 @default.
- W2106779017 creator A5019638425 @default.
- W2106779017 creator A5019646038 @default.
- W2106779017 creator A5019801327 @default.
- W2106779017 creator A5019960092 @default.
- W2106779017 creator A5020962383 @default.
- W2106779017 creator A5022385603 @default.
- W2106779017 creator A5022473427 @default.
- W2106779017 creator A5022554913 @default.
- W2106779017 creator A5022849571 @default.
- W2106779017 creator A5023154420 @default.
- W2106779017 creator A5024226928 @default.
- W2106779017 creator A5024786637 @default.
- W2106779017 creator A5026827841 @default.
- W2106779017 creator A5027231153 @default.
- W2106779017 creator A5027765428 @default.
- W2106779017 creator A5028605888 @default.
- W2106779017 creator A5029097636 @default.
- W2106779017 creator A5031212154 @default.
- W2106779017 creator A5034194110 @default.
- W2106779017 creator A5034417886 @default.
- W2106779017 creator A5035504682 @default.
- W2106779017 creator A5035961257 @default.
- W2106779017 creator A5035990606 @default.
- W2106779017 creator A5036281306 @default.
- W2106779017 creator A5036366637 @default.
- W2106779017 creator A5039043464 @default.
- W2106779017 creator A5040119863 @default.
- W2106779017 creator A5040354010 @default.
- W2106779017 creator A5040770914 @default.
- W2106779017 creator A5042501752 @default.
- W2106779017 creator A5042564659 @default.
- W2106779017 creator A5047644183 @default.
- W2106779017 creator A5049890044 @default.
- W2106779017 creator A5050694171 @default.
- W2106779017 creator A5050697653 @default.
- W2106779017 creator A5050737062 @default.
- W2106779017 creator A5051687315 @default.
- W2106779017 creator A5051870878 @default.
- W2106779017 creator A5051903151 @default.
- W2106779017 creator A5052113690 @default.
- W2106779017 creator A5052980249 @default.
- W2106779017 creator A5053486762 @default.
- W2106779017 creator A5057198707 @default.
- W2106779017 creator A5058586070 @default.
- W2106779017 creator A5059052168 @default.
- W2106779017 creator A5059435501 @default.
- W2106779017 creator A5060061551 @default.
- W2106779017 creator A5060728613 @default.
- W2106779017 creator A5062883630 @default.
- W2106779017 creator A5063645374 @default.
- W2106779017 creator A5064749062 @default.
- W2106779017 creator A5065356435 @default.
- W2106779017 creator A5065939741 @default.
- W2106779017 creator A5066218040 @default.
- W2106779017 creator A5067402350 @default.
- W2106779017 creator A5067791240 @default.
- W2106779017 creator A5069067500 @default.
- W2106779017 creator A5069192514 @default.
- W2106779017 creator A5070038178 @default.
- W2106779017 creator A5071883882 @default.
- W2106779017 creator A5072338399 @default.
- W2106779017 creator A5073286160 @default.
- W2106779017 creator A5073345578 @default.
- W2106779017 creator A5073531557 @default.
- W2106779017 creator A5073979520 @default.
- W2106779017 creator A5074121579 @default.
- W2106779017 creator A5076690928 @default.
- W2106779017 creator A5076996656 @default.
- W2106779017 creator A5077220554 @default.
- W2106779017 creator A5078128200 @default.
- W2106779017 creator A5078649698 @default.
- W2106779017 creator A5081489856 @default.
- W2106779017 creator A5082987648 @default.
- W2106779017 creator A5086525751 @default.
- W2106779017 creator A5088244425 @default.
- W2106779017 creator A5088248608 @default.
- W2106779017 creator A5088625283 @default.
- W2106779017 creator A5089543992 @default.