FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106794219> ?p ?o ?g. }

• W2106794219 endingPage "1371" @default.
• W2106794219 startingPage "1363" @default.
• W2106794219 abstract "Hepatocyte growth factor (HGF), a multifunctional cytokine of mesenchymal origin, activates the DNA binding of hypoxia inducible factor-1 (HIF-1) in the HepG2 cell line: the activated complex contained the inducible alpha subunit. An increased expression of HIF-1alpha (mRNA and nuclear protein levels) was observed. To investigate the molecular basis of the HIF-1 response under this non-hypoxic condition, we evaluated first the expression of putative target genes. We found a time-dependent increase in steady-state mRNA levels of heme oxygenase and urokinase plasminogen activator at 4 h, followed by that of urokinase receptor at 10 h. The enhanced expression of these genes might confer the invasive phenotype, since HGF is a proliferative and scatter factor. Second, we examined some aspects of HIF-1 activity regulation in HGF-treated cells with the following findings: (i) the activation of HIF-1 DNA binding was prevented by proteasome blockade, probably because stabilization of the cytosolic alpha-subunit protein level is not sufficient to generate a functional form: also under these conditions nuclear protein level of HIF-1alpha did not increase; (ii) N-acetylcysteine, a free radical scavenger, strongly decreased HIF-1 activation suggesting a role of reactive oxygen species in this process; (iii) the thiol reducing agent dithiothreitol was ineffective. Third, consistent with these data, N-acetylcysteine reduced the stimulatory effect of HGF on stress kinase activities, while p42/44 mitogen activated kinase (MAPK) was unmodified, suggesting an involvement of c-Jun-N-terminal kinase (JNK) and p38 MAPK in HIF-1 activation. Finally, LY 294002 induced the blockade of phosphatidylinositol 3-kinase (PI3K), one of the principal transducers of HGF/Met receptor signalling, prevented the enhancement of HIF-1 DNA binding and JNK activity, but the inhibition of p42/44 MAPK phosphorylation with PD 98059 was ineffective. In conclusion, we suggest that HGF triggers a signal transduction cascade involving PI3K and ultimately activates HIF-1." @default.
• W2106794219 created "2016-06-24" @default.
• W2106794219 creator A5009553750 @default.
• W2106794219 date "2001-09-01" @default.
• W2106794219 modified "2023-10-17" @default.
• W2106794219 title "Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells" @default.
• W2106794219 cites W1482629448 @default.
• W2106794219 cites W1483762900 @default.
• W2106794219 cites W1499987944 @default.
• W2106794219 cites W1504187225 @default.
• W2106794219 cites W1506656489 @default.
• W2106794219 cites W1545126968 @default.
• W2106794219 cites W1547863599 @default.
• W2106794219 cites W1567384416 @default.
• W2106794219 cites W1767331507 @default.
• W2106794219 cites W1853643611 @default.
• W2106794219 cites W1899552864 @default.
• W2106794219 cites W1928129824 @default.
• W2106794219 cites W1951978965 @default.
• W2106794219 cites W1964918262 @default.
• W2106794219 cites W1966504629 @default.
• W2106794219 cites W1973963032 @default.
• W2106794219 cites W1979964213 @default.
• W2106794219 cites W1980554224 @default.
• W2106794219 cites W1982376300 @default.
• W2106794219 cites W1991843895 @default.
• W2106794219 cites W1992449776 @default.
• W2106794219 cites W2000624133 @default.
• W2106794219 cites W2001046604 @default.
• W2106794219 cites W2005454488 @default.
• W2106794219 cites W2007919022 @default.
• W2106794219 cites W2013625361 @default.
• W2106794219 cites W2017805920 @default.
• W2106794219 cites W2019573100 @default.
• W2106794219 cites W2019759067 @default.
• W2106794219 cites W2021669660 @default.
• W2106794219 cites W2024206845 @default.
• W2106794219 cites W2025974453 @default.
• W2106794219 cites W2036451354 @default.
• W2106794219 cites W2040483232 @default.
• W2106794219 cites W2041111722 @default.
• W2106794219 cites W2054473882 @default.
• W2106794219 cites W2057101460 @default.
• W2106794219 cites W2057851499 @default.
• W2106794219 cites W2075980717 @default.
• W2106794219 cites W2077688090 @default.
• W2106794219 cites W2081635255 @default.
• W2106794219 cites W2081748503 @default.
• W2106794219 cites W2083077484 @default.
• W2106794219 cites W2096230949 @default.
• W2106794219 cites W2107410714 @default.
• W2106794219 cites W2112337731 @default.
• W2106794219 cites W2133013402 @default.
• W2106794219 cites W2134812217 @default.
• W2106794219 cites W2139466117 @default.
• W2106794219 cites W2148457804 @default.
• W2106794219 cites W2149982213 @default.
• W2106794219 cites W2160099462 @default.
• W2106794219 cites W2161027076 @default.
• W2106794219 cites W2300710538 @default.
• W2106794219 cites W2322182993 @default.
• W2106794219 cites W2323767042 @default.
• W2106794219 cites W2328274119 @default.
• W2106794219 cites W2418387234 @default.
• W2106794219 cites W326751094 @default.
• W2106794219 cites W3044574244 @default.
• W2106794219 doi "https://doi.org/10.1093/carcin/22.9.1363" @default.
• W2106794219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11532856" @default.
• W2106794219 hasPublicationYear "2001" @default.
• W2106794219 type Work @default.
• W2106794219 sameAs 2106794219 @default.
• W2106794219 citedByCount "169" @default.
• W2106794219 countsByYear W21067942192012 @default.
• W2106794219 countsByYear W21067942192013 @default.
• W2106794219 countsByYear W21067942192014 @default.
• W2106794219 countsByYear W21067942192015 @default.
• W2106794219 countsByYear W21067942192016 @default.
• W2106794219 countsByYear W21067942192017 @default.
• W2106794219 countsByYear W21067942192018 @default.
• W2106794219 countsByYear W21067942192019 @default.
• W2106794219 countsByYear W21067942192020 @default.
• W2106794219 countsByYear W21067942192021 @default.
• W2106794219 countsByYear W21067942192022 @default.
• W2106794219 countsByYear W21067942192023 @default.
• W2106794219 crossrefType "journal-article" @default.
• W2106794219 hasAuthorship W2106794219A5009553750 @default.
• W2106794219 hasBestOaLocation W21067942191 @default.
• W2106794219 hasConcept C134018914 @default.
• W2106794219 hasConcept C153911025 @default.
• W2106794219 hasConcept C170493617 @default.
• W2106794219 hasConcept C181199279 @default.
• W2106794219 hasConcept C184235292 @default.
• W2106794219 hasConcept C185592680 @default.
• W2106794219 hasConcept C2775960820 @default.
• W2106794219 hasConcept C2776996007 @default.
• W2106794219 hasConcept C2777824588 @default.
• W2106794219 hasConcept C2779679481 @default.
• W2106794219 hasConcept C51551487 @default.

• next