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• W2106804981 abstract "The deubiquitinating enzyme CYLD is an important tumor suppressor and inhibitor of immune responses. In contrast to full-length CYLD, the immunological function of the naturally occurring short splice variant of CYLD (sCYLD) is insufficiently described. Previously, we showed that DCs, which lack full-length CYLD but express sCYLD, exhibit augmented NF-κB and DC activation. To explore the function of sCYLD in infection, we investigated whether DC-specific sCYLD regulates the pathogenesis of listeriosis. Upon Listeria monocytogenes infection of CD11c-Cre Cyldex7/8 fl/fl mice, infection of CD8α+ DCs, which are crucial for the establishment of listeriosis in the spleen, was not affected. However, NF-κB activity of CD11c-Cre Cyldex7/8 fl/fl DCs was increased, while activation of ERK and p38 was normal. In addition, CD11c-Cre Cyldex7/8 fl/fl DCs produced more TNF, IL-10, and IL-12 upon infection, which led to enhanced stimulation of IFN-γ-producing NK cells. In addition CD11c-Cre Cyldex7/8 fl/fl DCs presented Listeria Ag more efficiently to CD8+ T cells resulting in a stronger pathogen-specific CD8+ T-cell proliferation and more IFN-γ production. Collectively, the improved innate and adaptive immunity and survival during listeriosis identify the DC-specific FL-CYLD/sCYLD balance as a potential target to modulate NK-cell and Ag-specific CD8+ T-cell responses." @default.
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• W2106804981 date "2015-03-19" @default.
• W2106804981 modified "2023-10-05" @default.
• W2106804981 title "Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full-length CYLD" @default.
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• W2106804981 doi "https://doi.org/10.1002/eji.201445116" @default.
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