FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106813936> ?p ?o ?g. }

• W2106813936 endingPage "1125" @default.
• W2106813936 startingPage "1118" @default.
• W2106813936 abstract "Summary. Haemophilia A displays phenotypic heterogeneity with respect to clinical severity. The aim of this study was to determine if tissue factor (TF)‐initiated thrombin generation profiles in whole blood in the presence of corn trypsin inhibitor (CTI) are predictive of bleeding risk in haemophilia A. We studied factor(F) VIII deficient individuals (11 mild, 4 moderate and 12 severe) with a well‐characterized 5‐year bleeding history that included haemarthrosis, soft tissue haematoma and annual FVIII concentrate usage. This clinical information was used to generate a bleeding score. The bleeding scores (range 0–32) were separated into three groups (bleeding score groupings: 0, 0 and ≤9.6, >9.6), with the higher bleeding tendency having a higher score. Whole blood collected by phlebotomy and contact pathway suppressed by 100 μg mL −1 CTI was stimulated to react by the addition of 5 p m TF. Reactions were quenched at 20 min by inhibitors. Thrombin generation, determined by enzyme‐linked immunosorbent assay for thrombin–antithrombin was evaluated in terms of clot time (CT), maximum level (MaxL) and maximum rate (MaxR) and compared to the bleeding score. Data are shown as the mean±SD. MaxL was significantly different ( P < 0.001) between the groups: 504 ± 114, 315 ± 117 and 194 ± 91 n m ; with higher thrombin concentrations in the groups with lower bleeding scores. MaxR was higher in the groups with a lower bleeding score; 97 ± 51, 86 ± 60 and 39 ± 16 n m min −1 ( P = 0.09). No significant difference was detected in CT among the groups, 5.6 ± 1.3, 4.7 ± 0.7 and 5.6 ± 1.3 min. Our empirical study in CTI‐inhibited whole blood shows that the MaxL of thrombin generation appears to correlate with the bleeding phenotype of haemophilia A." @default.
• W2106813936 created "2016-06-24" @default.
• W2106813936 creator A5015874992 @default.
• W2106813936 creator A5063128853 @default.
• W2106813936 creator A5075389112 @default.
• W2106813936 creator A5077684080 @default.
• W2106813936 creator A5082402491 @default.
• W2106813936 date "2009-08-26" @default.
• W2106813936 modified "2023-10-16" @default.
• W2106813936 title "Thrombin generation and bleeding in haemophilia A" @default.
• W2106813936 cites W110545565 @default.
• W2106813936 cites W187459506 @default.
• W2106813936 cites W194949005 @default.
• W2106813936 cites W1966885896 @default.
• W2106813936 cites W1967735174 @default.
• W2106813936 cites W1968413192 @default.
• W2106813936 cites W1984933082 @default.
• W2106813936 cites W1991130709 @default.
• W2106813936 cites W1994393898 @default.
• W2106813936 cites W2001586047 @default.
• W2106813936 cites W2012551708 @default.
• W2106813936 cites W2021015575 @default.
• W2106813936 cites W2023412739 @default.
• W2106813936 cites W2026502021 @default.
• W2106813936 cites W2026954003 @default.
• W2106813936 cites W2031424136 @default.
• W2106813936 cites W2031515989 @default.
• W2106813936 cites W2033457526 @default.
• W2106813936 cites W2034647149 @default.
• W2106813936 cites W2036348577 @default.
• W2106813936 cites W2040219980 @default.
• W2106813936 cites W2044717045 @default.
• W2106813936 cites W2051039082 @default.
• W2106813936 cites W2056974529 @default.
• W2106813936 cites W2058161894 @default.
• W2106813936 cites W2061216302 @default.
• W2106813936 cites W2062673895 @default.
• W2106813936 cites W2065239640 @default.
• W2106813936 cites W2088598503 @default.
• W2106813936 cites W2119446923 @default.
• W2106813936 cites W2122004095 @default.
• W2106813936 cites W2128435780 @default.
• W2106813936 cites W2131384825 @default.
• W2106813936 cites W2135486988 @default.
• W2106813936 cites W2136829113 @default.
• W2106813936 cites W2139158876 @default.
• W2106813936 cites W2139192027 @default.
• W2106813936 cites W2169958999 @default.
• W2106813936 cites W2295465622 @default.
• W2106813936 cites W2404763720 @default.
• W2106813936 cites W4230915316 @default.
• W2106813936 cites W4296345809 @default.
• W2106813936 cites W986770207 @default.
• W2106813936 doi "https://doi.org/10.1111/j.1365-2516.2009.01994.x" @default.
• W2106813936 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3395070" @default.
• W2106813936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19563500" @default.
• W2106813936 hasPublicationYear "2009" @default.
• W2106813936 type Work @default.
• W2106813936 sameAs 2106813936 @default.
• W2106813936 citedByCount "50" @default.
• W2106813936 countsByYear W21068139362012 @default.
• W2106813936 countsByYear W21068139362013 @default.
• W2106813936 countsByYear W21068139362014 @default.
• W2106813936 countsByYear W21068139362015 @default.
• W2106813936 countsByYear W21068139362016 @default.
• W2106813936 countsByYear W21068139362017 @default.
• W2106813936 countsByYear W21068139362018 @default.
• W2106813936 countsByYear W21068139362019 @default.
• W2106813936 countsByYear W21068139362020 @default.
• W2106813936 countsByYear W21068139362021 @default.
• W2106813936 countsByYear W21068139362022 @default.
• W2106813936 countsByYear W21068139362023 @default.
• W2106813936 crossrefType "journal-article" @default.
• W2106813936 hasAuthorship W2106813936A5015874992 @default.
• W2106813936 hasAuthorship W2106813936A5063128853 @default.
• W2106813936 hasAuthorship W2106813936A5075389112 @default.
• W2106813936 hasAuthorship W2106813936A5077684080 @default.
• W2106813936 hasAuthorship W2106813936A5082402491 @default.
• W2106813936 hasBestOaLocation W21068139362 @default.
• W2106813936 hasConcept C126322002 @default.
• W2106813936 hasConcept C141071460 @default.
• W2106813936 hasConcept C186738567 @default.
• W2106813936 hasConcept C2777232031 @default.
• W2106813936 hasConcept C2777292125 @default.
• W2106813936 hasConcept C2777357209 @default.
• W2106813936 hasConcept C2777557582 @default.
• W2106813936 hasConcept C2778382381 @default.
• W2106813936 hasConcept C2778385053 @default.
• W2106813936 hasConcept C2779026020 @default.
• W2106813936 hasConcept C2779216453 @default.
• W2106813936 hasConcept C2779526002 @default.
• W2106813936 hasConcept C2993802102 @default.
• W2106813936 hasConcept C3018972837 @default.
• W2106813936 hasConcept C71924100 @default.
• W2106813936 hasConcept C89560881 @default.
• W2106813936 hasConcept C90924648 @default.
• W2106813936 hasConceptScore W2106813936C126322002 @default.
• W2106813936 hasConceptScore W2106813936C141071460 @default.

• next