Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106820006> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2106820006 endingPage "169" @default.
- W2106820006 startingPage "160" @default.
- W2106820006 abstract "Abstract: GT1-7 cells, a clonal line derived from specific tumours of gonadotropin-releasing hormone-secreting neurons from mouse hypothalamus, were used as a model system to investigate the cellular mechanisms underlying the histamine H1 receptor-mediated desensitisation. GT1-7 cells contain H1 receptors, acute stimulation of which leads to the desensitisation of histamine-mediated calcium mobilisation and is manifest as a concurrent reduction in both the magnitude of the calcium transient and of the sustained phase. Acute pretreatment of the cells with the phorbol ester, phorbol 12-myristate 13-acetate, can also ablate the histamine-stimulated calcium mobilisation. In addition, acute H1-receptor stimulation and acute phorbol ester treatment result in the attenuation of histamine-mediated inositol phosphate production. Receptor desensitisation resulting from acute stimulation with histamine is not affected by inhibiting protein kinase C (PKC) activity with Ro 31-7549 or staurosporine. In contrast, the desensitisation of H1-receptor responses induced by direct activation of protein kinase C is preventable by PKC inhibitors. Thus, these results imply that a PKC-dependent mechanism and PKC-independent mechanism are involved in the H1-receptor desensitisation cascade in GT1-7 cells and do not support the involvement of PKC in the receptor-mediated desensitisation of H1 receptor-stimulated calcium and inositol phosphate responses." @default.
- W2106820006 created "2016-06-24" @default.
- W2106820006 creator A5001171901 @default.
- W2106820006 creator A5001283694 @default.
- W2106820006 creator A5039199217 @default.
- W2106820006 date "2002-11-23" @default.
- W2106820006 modified "2023-09-24" @default.
- W2106820006 title "Receptor-Mediated Desensitisation of Histamine H1 Receptor-Stimulated Inositol Phosphate Production and Calcium Mobilisation in GT1-7 Neuronal Cells Is Independent of Protein Kinase C" @default.
- W2106820006 doi "https://doi.org/10.1046/j.1471-4159.1995.65010160.x" @default.
- W2106820006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7790857" @default.
- W2106820006 hasPublicationYear "2002" @default.
- W2106820006 type Work @default.
- W2106820006 sameAs 2106820006 @default.
- W2106820006 citedByCount "17" @default.
- W2106820006 countsByYear W21068200062019 @default.
- W2106820006 crossrefType "journal-article" @default.
- W2106820006 hasAuthorship W2106820006A5001171901 @default.
- W2106820006 hasAuthorship W2106820006A5001283694 @default.
- W2106820006 hasAuthorship W2106820006A5039199217 @default.
- W2106820006 hasConcept C10335311 @default.
- W2106820006 hasConcept C1122143 @default.
- W2106820006 hasConcept C126322002 @default.
- W2106820006 hasConcept C134018914 @default.
- W2106820006 hasConcept C159545944 @default.
- W2106820006 hasConcept C170493617 @default.
- W2106820006 hasConcept C185592680 @default.
- W2106820006 hasConcept C195794163 @default.
- W2106820006 hasConcept C24998067 @default.
- W2106820006 hasConcept C2776885963 @default.
- W2106820006 hasConcept C2777427919 @default.
- W2106820006 hasConcept C2778618036 @default.
- W2106820006 hasConcept C2779084600 @default.
- W2106820006 hasConcept C2780043322 @default.
- W2106820006 hasConcept C2781387506 @default.
- W2106820006 hasConcept C519063684 @default.
- W2106820006 hasConcept C62478195 @default.
- W2106820006 hasConcept C71924100 @default.
- W2106820006 hasConcept C86803240 @default.
- W2106820006 hasConcept C95444343 @default.
- W2106820006 hasConceptScore W2106820006C10335311 @default.
- W2106820006 hasConceptScore W2106820006C1122143 @default.
- W2106820006 hasConceptScore W2106820006C126322002 @default.
- W2106820006 hasConceptScore W2106820006C134018914 @default.
- W2106820006 hasConceptScore W2106820006C159545944 @default.
- W2106820006 hasConceptScore W2106820006C170493617 @default.
- W2106820006 hasConceptScore W2106820006C185592680 @default.
- W2106820006 hasConceptScore W2106820006C195794163 @default.
- W2106820006 hasConceptScore W2106820006C24998067 @default.
- W2106820006 hasConceptScore W2106820006C2776885963 @default.
- W2106820006 hasConceptScore W2106820006C2777427919 @default.
- W2106820006 hasConceptScore W2106820006C2778618036 @default.
- W2106820006 hasConceptScore W2106820006C2779084600 @default.
- W2106820006 hasConceptScore W2106820006C2780043322 @default.
- W2106820006 hasConceptScore W2106820006C2781387506 @default.
- W2106820006 hasConceptScore W2106820006C519063684 @default.
- W2106820006 hasConceptScore W2106820006C62478195 @default.
- W2106820006 hasConceptScore W2106820006C71924100 @default.
- W2106820006 hasConceptScore W2106820006C86803240 @default.
- W2106820006 hasConceptScore W2106820006C95444343 @default.
- W2106820006 hasIssue "1" @default.
- W2106820006 hasLocation W21068200061 @default.
- W2106820006 hasLocation W21068200062 @default.
- W2106820006 hasOpenAccess W2106820006 @default.
- W2106820006 hasPrimaryLocation W21068200061 @default.
- W2106820006 hasRelatedWork W1996347805 @default.
- W2106820006 hasRelatedWork W2060198190 @default.
- W2106820006 hasRelatedWork W2068138337 @default.
- W2106820006 hasRelatedWork W2071752363 @default.
- W2106820006 hasRelatedWork W2077411065 @default.
- W2106820006 hasRelatedWork W2106820006 @default.
- W2106820006 hasRelatedWork W2270448269 @default.
- W2106820006 hasRelatedWork W2414105590 @default.
- W2106820006 hasRelatedWork W2414797317 @default.
- W2106820006 hasRelatedWork W4242104882 @default.
- W2106820006 hasVolume "65" @default.
- W2106820006 isParatext "false" @default.
- W2106820006 isRetracted "false" @default.
- W2106820006 magId "2106820006" @default.
- W2106820006 workType "article" @default.