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- W2106851567 abstract "The eventual phaseout of chlorofluorocarbons by the year 2000 has resulted in an intense search for replacement agents. A novel in vitro exposure system utilizing anchorage-dependent cell cultures has been developed to rapidly screen newly developed volatile replacement candidates for potential in vivo toxicity. Primary and WB344 immortalized rat hepatocytes were exposed to candidate volatile agents at 10,000, 100,000, and 500,000 ppm for 4 and 24 h. 1-Chloro-1,2,2-tetrafluoroethane (HCFC-124) and 1-chloro-1,1-difluoroethane (HCFC-142b)were not found to be cytotoxic using enzyme leakageas an indicator of cell damage. Exposure of primary hepatocytes to 500,000 ppm of 2,2-dichloro1,1,1-trifluoroethane (HCFC-123) indicated significant cytosolic lactate dehydrogenase and mitochondrial aspartate S-aminotransferase enzyme leakage at 4 and 24 h. Exposure of these hepatocytes to a mixture of HCFC-123/142b (80/20%) at 500,000 ppm indicated significant enzyme leakage after 24 h of exposure. Exposure of the WB344 he..." @default.
- W2106851567 created "2016-06-24" @default.
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- W2106851567 date "1999-01-01" @default.
- W2106851567 modified "2023-09-27" @default.
- W2106851567 title "NOVEL IN VITRO METHOD FOR RAPID SCREENING OF VOLATILE COMPOUNDS USING PRIMARY OR IMMORTALIZED RAT HEPATOCYTES" @default.
- W2106851567 doi "https://doi.org/10.1080/105172399242654" @default.
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