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• W2106856225 abstract "<h3>Objectives</h3> This subanalysis of the Study of the Effects of Nebivolol Intervention on Outcomes and Hospitalisation in Seniors with Heart Failure (SENIORS) investigates whether treatment with nebivolol, a β-blocker with nitric oxide-releasing properties, can provide additional benefits besides its effects on heart failure (HF), by reducing cardiac ischaemic events in patients with HF of ischaemic aetiology. <h3>Design</h3> A double-blind, randomised, placebo-controlled, multicentre trial of nebivolol in 2128 elderly patients. <h3>Patients and interventions</h3> For this analysis, data were extracted for 2128 elderly (≥70 years) HF patients in whom coronary artery disease (CAD) was the underlying aetiology (68.2%; 717 placebo-treated patients and 735 assigned to nebivolol). <h3>Main outcome measures</h3> The main endpoint was the composite of cardiac ischaemic events at 2 year follow-up: death/hospitalisation for myocardial infarction, unstable angina or sudden death, as originally identified in the case report form. <h3>Results</h3> At follow-up, nebivolol treatment was associated with a one-third reduction in the risk of ischaemic events, the composite endpoint occurring in 15.9% of placebo and 10.7% of nebivolol-treated patients (HR 0.68; 95% CI 0.51 to 0.90; p=0.008). This effect was independent of age, gender and ejection fraction. No difference in this composite endpoint was observed in the subgroup of patients of non-ischaemic aetiology. <h3>Conclusions</h3> Nebivolol was effective in reducing cardiac ischaemic events in patients with HF of ischaemic aetiology. The prevention of ischaemic events can be an additional beneficial effect of β-blockade in HF patients with underlying CAD." @default.
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• W2106856225 date "2010-12-06" @default.
• W2106856225 modified "2023-10-14" @default.
• W2106856225 title " -blockade with nebivolol for prevention of acute ischaemic events in elderly patients with heart failure" @default.
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• W2106856225 doi "https://doi.org/10.1136/hrt.2010.207365" @default.
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