FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106862880> ?p ?o ?g. }

• W2106862880 endingPage "6" @default.
• W2106862880 startingPage "1710" @default.
• W2106862880 abstract "Clinically, human testicular nonseminomatous germ cell tumors exhibit remarkable sensitivity to platinum-based chemotherapy. To define better the mechanistic basis for this unusual sensitivity, the biochemical determinants of platinum-induced cytotoxicity have been investigated in a human testicular tumor cell line (GCT27) established from a previously untreated patient and in an in vitro derived 5.6-fold cisplatin-resistant stable variant (GCT27cisR). Compared to 12 ovarian and 5 cervical human tumor cell lines, the parent GCT27 line was among the most sensitive to the cytotoxic effects of both cisplatin (dosage producing 50% inhibition, 0.2 microM) and carboplatin (dosage producing 50% inhibition, 2.9 microM), thus reflecting clinical data. A 4-day exposure sulforhodamine B-staining assay was used to determine that GCT27cisR was cross-resistant to carboplatin and iproplatin and the classical bifunctional alkylating agents melphalan and chlorambucil. Partial cross-resistance was observed to tetraplatin, methotrexate, and mitomycin C. No cross-resistance was observed to Adriamycin, etoposide, vinblastine, bleomycin, 1-beta-D-arabinofuranosylcytosine, and 5-fluorouracil. Intracellular cisplatin accumulation across the dose range 2.5-100 microM (for 2 h) was 1.6 +/- 0.39-fold (mean +/- SD) greater for the parent line. There was no significant difference in glutathione levels between the two lines. The acquired resistance line was 1.9-fold more resistant than the parent line to the cytotoxic effects of cadmium chloride. There was no significant difference between the two lines, however, in the total amounts of platinum bound to DNA after cisplatin exposure (25, 50, or 100 microM for 2 h). The removal of total platinum adducts from DNA was significantly faster for GCT27cisR compared to the parent line (half-times of removal, 32 and 67 h, respectively). These data suggest that the abnormal sensitivity of the parent testicular tumor cell line to platinum-containing anticancer drugs may be due predominantly to an inherent defect in the ability of these cells to remove platinum from their DNA. This defect is apparently lost in the acquired resistance counterpart. Reduced intracellular accumulation and increased cytoplasmic concentrations of metallothionein may also contribute, in part, to the acquisition of cisplatin resistance in this model." @default.
• W2106862880 created "2016-06-24" @default.
• W2106862880 creator A5005075154 @default.
• W2106862880 creator A5024631960 @default.
• W2106862880 creator A5037605626 @default.
• W2106862880 creator A5041062763 @default.
• W2106862880 creator A5049488273 @default.
• W2106862880 creator A5054694355 @default.
• W2106862880 creator A5067466730 @default.
• W2106862880 date "1992-04-01" @default.
• W2106862880 modified "2023-09-26" @default.
• W2106862880 title "Establishment and characterization of an in vitro model of acquired resistance to cisplatin in a human testicular nonseminomatous germ cell line." @default.
• W2106862880 cites W1497614830 @default.
• W2106862880 cites W1528896526 @default.
• W2106862880 cites W1535524422 @default.
• W2106862880 cites W1537210398 @default.
• W2106862880 cites W1551388901 @default.
• W2106862880 cites W1559606952 @default.
• W2106862880 cites W1775749144 @default.
• W2106862880 cites W1967061702 @default.
• W2106862880 cites W1971121047 @default.
• W2106862880 cites W1976909001 @default.
• W2106862880 cites W1979219645 @default.
• W2106862880 cites W1983426353 @default.
• W2106862880 cites W1987437563 @default.
• W2106862880 cites W2000085019 @default.
• W2106862880 cites W2003003988 @default.
• W2106862880 cites W2003914447 @default.
• W2106862880 cites W2022383292 @default.
• W2106862880 cites W2024844244 @default.
• W2106862880 cites W2026327431 @default.
• W2106862880 cites W2033321871 @default.
• W2106862880 cites W2049726669 @default.
• W2106862880 cites W2056359433 @default.
• W2106862880 cites W2060372099 @default.
• W2106862880 cites W2060524209 @default.
• W2106862880 cites W2064721088 @default.
• W2106862880 cites W2078125348 @default.
• W2106862880 cites W2093279095 @default.
• W2106862880 cites W2106722489 @default.
• W2106862880 cites W2115663377 @default.
• W2106862880 cites W2116030385 @default.
• W2106862880 cites W2117786645 @default.
• W2106862880 cites W2137211272 @default.
• W2106862880 cites W2156591820 @default.
• W2106862880 cites W2165915598 @default.
• W2106862880 cites W2270792714 @default.
• W2106862880 cites W2339809149 @default.
• W2106862880 cites W2411364942 @default.
• W2106862880 cites W2504630193 @default.
• W2106862880 cites W45574792 @default.
• W2106862880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1312897" @default.
• W2106862880 hasPublicationYear "1992" @default.
• W2106862880 type Work @default.
• W2106862880 sameAs 2106862880 @default.
• W2106862880 citedByCount "33" @default.
• W2106862880 countsByYear W21068628802012 @default.
• W2106862880 countsByYear W21068628802013 @default.
• W2106862880 countsByYear W21068628802016 @default.
• W2106862880 countsByYear W21068628802018 @default.
• W2106862880 countsByYear W21068628802019 @default.
• W2106862880 countsByYear W21068628802022 @default.
• W2106862880 crossrefType "journal-article" @default.
• W2106862880 hasAuthorship W2106862880A5005075154 @default.
• W2106862880 hasAuthorship W2106862880A5024631960 @default.
• W2106862880 hasAuthorship W2106862880A5037605626 @default.
• W2106862880 hasAuthorship W2106862880A5041062763 @default.
• W2106862880 hasAuthorship W2106862880A5049488273 @default.
• W2106862880 hasAuthorship W2106862880A5054694355 @default.
• W2106862880 hasAuthorship W2106862880A5067466730 @default.
• W2106862880 hasConcept C126322002 @default.
• W2106862880 hasConcept C203014093 @default.
• W2106862880 hasConcept C2776694085 @default.
• W2106862880 hasConcept C2776755627 @default.
• W2106862880 hasConcept C2776938808 @default.
• W2106862880 hasConcept C2777132456 @default.
• W2106862880 hasConcept C2777866208 @default.
• W2106862880 hasConcept C2778119113 @default.
• W2106862880 hasConcept C2778239845 @default.
• W2106862880 hasConcept C2778684742 @default.
• W2106862880 hasConcept C2781451048 @default.
• W2106862880 hasConcept C502942594 @default.
• W2106862880 hasConcept C71924100 @default.
• W2106862880 hasConcept C86803240 @default.
• W2106862880 hasConcept C98274493 @default.
• W2106862880 hasConceptScore W2106862880C126322002 @default.
• W2106862880 hasConceptScore W2106862880C203014093 @default.
• W2106862880 hasConceptScore W2106862880C2776694085 @default.
• W2106862880 hasConceptScore W2106862880C2776755627 @default.
• W2106862880 hasConceptScore W2106862880C2776938808 @default.
• W2106862880 hasConceptScore W2106862880C2777132456 @default.
• W2106862880 hasConceptScore W2106862880C2777866208 @default.
• W2106862880 hasConceptScore W2106862880C2778119113 @default.
• W2106862880 hasConceptScore W2106862880C2778239845 @default.
• W2106862880 hasConceptScore W2106862880C2778684742 @default.
• W2106862880 hasConceptScore W2106862880C2781451048 @default.
• W2106862880 hasConceptScore W2106862880C502942594 @default.
• W2106862880 hasConceptScore W2106862880C71924100 @default.

• next