Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106875582> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2106875582 endingPage "713" @default.
- W2106875582 startingPage "710" @default.
- W2106875582 abstract "Bisphosphonates have high affinity for hydroxyapatite (HA), which is abundantly present in bone. Also, platinum complexes are known that have a wide spectrum of antitumor activities. The conjugate of bisphosphonate and a platinum complex might have HA affinity and antitumor activity, and become a drug for metastatic bone tumor. In this study, the authors synthesized platinum complexes that had dialkyl bisphosphonic acid as a ligand, and evaluated the possibility of the synthesized complexes as a drug for metastatic bone tumor. The synthesized dialkyl bisphosphonate platinum(II) complex was characterized, and its stability in an aqueous solution was also confirmed. The synthesized platinum complex showed higher HA affinity than other platinum complexes such as cisplatin and carboplatin in an experiment of adsorption to HA. In vitro, the platinum complex showed tumor growth inhibitory effect stronger than or equal to cisplatin, which is the most commonly used antitumor agent. Moreover, the platinum complex showed a bone absorption inhibitory effect on the osteoclast. These results suggest potential of dialkyl bisphosphonate platinum(II) complexes as a drug for metastatic bone tumor." @default.
- W2106875582 created "2016-06-24" @default.
- W2106875582 creator A5007428793 @default.
- W2106875582 creator A5010278449 @default.
- W2106875582 creator A5025387150 @default.
- W2106875582 creator A5057494257 @default.
- W2106875582 creator A5075822126 @default.
- W2106875582 creator A5074744217 @default.
- W2106875582 date "2011-01-01" @default.
- W2106875582 modified "2023-09-23" @default.
- W2106875582 title "Dialkyl Bisphosphonate Platinum(II) Complex as a Potential Drug for Metastatic Bone Tumor" @default.
- W2106875582 cites W1967637692 @default.
- W2106875582 cites W1968544440 @default.
- W2106875582 cites W1975484288 @default.
- W2106875582 cites W2000780867 @default.
- W2106875582 cites W2002502453 @default.
- W2106875582 cites W2004799062 @default.
- W2106875582 cites W2032553799 @default.
- W2106875582 cites W2045891124 @default.
- W2106875582 cites W2055802170 @default.
- W2106875582 cites W2085163461 @default.
- W2106875582 cites W2111570380 @default.
- W2106875582 cites W2122731269 @default.
- W2106875582 cites W2126883991 @default.
- W2106875582 cites W2142702057 @default.
- W2106875582 cites W2168100008 @default.
- W2106875582 cites W2180244132 @default.
- W2106875582 doi "https://doi.org/10.1248/cpb.59.710" @default.
- W2106875582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21628905" @default.
- W2106875582 hasPublicationYear "2011" @default.
- W2106875582 type Work @default.
- W2106875582 sameAs 2106875582 @default.
- W2106875582 citedByCount "18" @default.
- W2106875582 countsByYear W21068755822012 @default.
- W2106875582 countsByYear W21068755822013 @default.
- W2106875582 countsByYear W21068755822015 @default.
- W2106875582 countsByYear W21068755822016 @default.
- W2106875582 countsByYear W21068755822017 @default.
- W2106875582 countsByYear W21068755822018 @default.
- W2106875582 countsByYear W21068755822019 @default.
- W2106875582 countsByYear W21068755822020 @default.
- W2106875582 countsByYear W21068755822021 @default.
- W2106875582 countsByYear W21068755822022 @default.
- W2106875582 countsByYear W21068755822023 @default.
- W2106875582 crossrefType "journal-article" @default.
- W2106875582 hasAuthorship W2106875582A5007428793 @default.
- W2106875582 hasAuthorship W2106875582A5010278449 @default.
- W2106875582 hasAuthorship W2106875582A5025387150 @default.
- W2106875582 hasAuthorship W2106875582A5057494257 @default.
- W2106875582 hasAuthorship W2106875582A5074744217 @default.
- W2106875582 hasAuthorship W2106875582A5075822126 @default.
- W2106875582 hasBestOaLocation W21068755821 @default.
- W2106875582 hasConcept C116569031 @default.
- W2106875582 hasConcept C126322002 @default.
- W2106875582 hasConcept C161790260 @default.
- W2106875582 hasConcept C170493617 @default.
- W2106875582 hasConcept C185592680 @default.
- W2106875582 hasConcept C2776541429 @default.
- W2106875582 hasConcept C2776694085 @default.
- W2106875582 hasConcept C2777251235 @default.
- W2106875582 hasConcept C2778239845 @default.
- W2106875582 hasConcept C2781451048 @default.
- W2106875582 hasConcept C518104683 @default.
- W2106875582 hasConcept C55493867 @default.
- W2106875582 hasConcept C71924100 @default.
- W2106875582 hasConceptScore W2106875582C116569031 @default.
- W2106875582 hasConceptScore W2106875582C126322002 @default.
- W2106875582 hasConceptScore W2106875582C161790260 @default.
- W2106875582 hasConceptScore W2106875582C170493617 @default.
- W2106875582 hasConceptScore W2106875582C185592680 @default.
- W2106875582 hasConceptScore W2106875582C2776541429 @default.
- W2106875582 hasConceptScore W2106875582C2776694085 @default.
- W2106875582 hasConceptScore W2106875582C2777251235 @default.
- W2106875582 hasConceptScore W2106875582C2778239845 @default.
- W2106875582 hasConceptScore W2106875582C2781451048 @default.
- W2106875582 hasConceptScore W2106875582C518104683 @default.
- W2106875582 hasConceptScore W2106875582C55493867 @default.
- W2106875582 hasConceptScore W2106875582C71924100 @default.
- W2106875582 hasIssue "6" @default.
- W2106875582 hasLocation W21068755821 @default.
- W2106875582 hasLocation W21068755822 @default.
- W2106875582 hasOpenAccess W2106875582 @default.
- W2106875582 hasPrimaryLocation W21068755821 @default.
- W2106875582 hasRelatedWork W104261504 @default.
- W2106875582 hasRelatedWork W2354160329 @default.
- W2106875582 hasRelatedWork W2386090956 @default.
- W2106875582 hasRelatedWork W2778342244 @default.
- W2106875582 hasRelatedWork W2910347614 @default.
- W2106875582 hasRelatedWork W4241636496 @default.
- W2106875582 hasRelatedWork W4361810916 @default.
- W2106875582 hasRelatedWork W4362420248 @default.
- W2106875582 hasRelatedWork W4362420406 @default.
- W2106875582 hasRelatedWork W4362461940 @default.
- W2106875582 hasVolume "59" @default.
- W2106875582 isParatext "false" @default.
- W2106875582 isRetracted "false" @default.
- W2106875582 magId "2106875582" @default.
- W2106875582 workType "article" @default.