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• W2106875608 abstract "In the present study, we examined the role of the recently identified glycosylphosphatidylinositol (GPI)‐anchored cell surface molecule BY55, assigned as CD160, in TCR signaling. CD160 is expressed by most intestinal intraepithelial lymphocytes and by a minor subset of circulating lymphocytes including NK, TCRγδ and cytotoxic effector CD8bright+CD28– T lymphocytes. We report that CD160, which has a broad specificity for MHC class Ia and Ib molecules, behaves as a co‐receptor upon T cell activation. Anti‐CD160 mAb enhance the CD3‐induced proliferation of freshly isolated CD160‐enriched peripheral blood lymphocytes and CD160+ T cell clones. Further, the engagement of CD160 receptors on normal clonal T lymphocyte populations lacking CD4, CD8 and CD28 molecules by MHC class I molecules results in an increased CD3‐induced cell proliferation. Further, we found that CD160 co‐precipitates with the protein tyrosine kinase p56lck and tyrosine phosphorylated ζ chains upon TCR–CD3 cell activation. Thus, we demonstrate that CD160 provides co‐stimulatory signals leading to the expansion of a minor subset of circulating lymphocytes including double‐negative CD4/CD8 T lymphocytes and CD8bright+ cytotoxic effector T lymphocytes lacking CD28 expression." @default.
• W2106875608 created "2016-06-24" @default.
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• W2106875608 date "2002-05-01" @default.
• W2106875608 modified "2023-09-30" @default.
• W2106875608 title "BY55/CD160 acts as a co‐receptor in TCR signal transduction of a human circulating cytotoxic effector T lymphocyte subset lacking CD28 expression" @default.
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• W2106875608 doi "https://doi.org/10.1093/intimm/14.5.445" @default.
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