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• W2106875810 abstract "Obesity is a challenging health problem in Western societies. It is a risk factor for cardiovascular morbidity and mortality. Recent studies showed that adipose tissue is not only a passive energy store, but also an active endocrine organ, the secretions of which influence the function of many systems. It has been well known for decades that obesity influences the main ‘players’ of blood pressure regulation, in other words, the heart (increased cardiac output, cardiomyocyte hypertrophy), blood vessels (atherosclerotic changes, increased vascular resistance secondary to hypertrophy of vascular myocytes, increased vascular tone induced by sympathetic activity, abnormal paracrineuautocrine function of the endothelial cells), kidneys (sodium retention, activation of the renal renin-angiotensin system, development of obesityrelated glomerulopathy), and the sympathetic nervous system (enhanced activity). In addition, obesity leads to endocrine, metabolic, haemostatic and haematological abnormalities." @default.
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• W2106875810 date "2002-02-01" @default.
• W2106875810 modified "2023-10-14" @default.
• W2106875810 title "The adipose tissue—a novel endocrine organ of interest to the nephrologist" @default.
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• W2106875810 doi "https://doi.org/10.1093/ndt/17.2.191" @default.
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