FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106879049> ?p ?o ?g. }

• W2106879049 endingPage "41" @default.
• W2106879049 startingPage "35" @default.
• W2106879049 abstract "The institution of inhaled corticosteroids is generally advocated for effective treatment of patients with asthma. It is yet unknown what is the best time to start inhaled corticosteroid therapy and especially whether delayed introduction is harmful. PHASE 1: In a previous study in patients with asthma and COPD, we found that 2.5 years of treatment with a beta 2-agonist plus inhaled corticosteroid (BA + CS) was more effective in improving the FEV1 and the provocative concentration of histamine causing a 20% reduction in FEV1 (PC20) than treatment with a beta 2-agonist plus anticholinergic (BA + AC) or placebo (BA + PL). PHASE 2: We extended this study with 6 months to investigate whether delayed introduction of inhaled CS therapy (800 micrograms beclomethasone dipropionate) in the groups previously not treated with inhaled CS (BA +/- AC) could also improve FEV1 and PC20 to the same degree. A distinction was made between patients with predominantly asthma (high baseline reversibility, delta FEV1 > or = 9% of predicted), and predominantly COPD (low baseline reversibility, delta FEV1 < 9% of predicted).Improvement of FEV1 percent predicted by inhaled CS was comparable both in the asthmatics between phase 1 (13.8% predicted) and phase 2 (8.5% predicted; p = 0.31) as well as in the patients with COPD (2.5% and 1.5% predicted, respectively). PC20, however, increased significantly more in the asthmatics in phase 1 (1.77 doubling concentration [DC]) than in phase 2 (0.79 DC; p = 0.03). Improvement of PC20 in the patients with COPD was not significantly higher in phase 1 (0.74 DC) than in phase 2 (0.00 DC; p = 0.19).Our study indicates that although delayed introduction of inhaled CS in asthmatics leads to similar improvements in FEV1, improvements in PC20 are significantly less. These findings in patients with longer-existing asthma concur with other findings in newly detected asthma. We suggest that institution of inhaled CS therapy should not be postponed in asthmatics with documented airways obstruction and reversibility." @default.
• W2106879049 created "2016-06-24" @default.
• W2106879049 creator A5013428765 @default.
• W2106879049 creator A5030603878 @default.
• W2106879049 creator A5035223402 @default.
• W2106879049 creator A5060835385 @default.
• W2106879049 creator A5064808545 @default.
• W2106879049 date "1996-07-01" @default.
• W2106879049 modified "2023-09-25" @default.
• W2106879049 title "Is Delayed Introduction of Inhaled Corticosteroids Harmful in Patients With Obstructive Airways Disease (Asthma and COPD)?" @default.
• W2106879049 cites W1963658547 @default.
• W2106879049 cites W1969153504 @default.
• W2106879049 cites W1982881630 @default.
• W2106879049 cites W1985064201 @default.
• W2106879049 cites W1988509624 @default.
• W2106879049 cites W1990951259 @default.
• W2106879049 cites W2015260858 @default.
• W2106879049 cites W2031867711 @default.
• W2106879049 cites W2031880739 @default.
• W2106879049 cites W2037483031 @default.
• W2106879049 cites W2041321156 @default.
• W2106879049 cites W2042203870 @default.
• W2106879049 cites W2050030715 @default.
• W2106879049 cites W2052683492 @default.
• W2106879049 cites W2054265626 @default.
• W2106879049 cites W2060279005 @default.
• W2106879049 cites W2073648450 @default.
• W2106879049 cites W2077902722 @default.
• W2106879049 cites W2081835439 @default.
• W2106879049 cites W2092597847 @default.
• W2106879049 cites W2094263667 @default.
• W2106879049 cites W2103198607 @default.
• W2106879049 cites W2137401824 @default.
• W2106879049 cites W2138500715 @default.
• W2106879049 cites W2146237101 @default.
• W2106879049 cites W2331642892 @default.
• W2106879049 cites W2337807480 @default.
• W2106879049 cites W2337893001 @default.
• W2106879049 doi "https://doi.org/10.1378/chest.110.1.35" @default.
• W2106879049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8681660" @default.
• W2106879049 hasPublicationYear "1996" @default.
• W2106879049 type Work @default.
• W2106879049 sameAs 2106879049 @default.
• W2106879049 citedByCount "88" @default.
• W2106879049 countsByYear W21068790492012 @default.
• W2106879049 countsByYear W21068790492013 @default.
• W2106879049 countsByYear W21068790492014 @default.
• W2106879049 countsByYear W21068790492015 @default.
• W2106879049 countsByYear W21068790492021 @default.
• W2106879049 countsByYear W21068790492023 @default.
• W2106879049 crossrefType "journal-article" @default.
• W2106879049 hasAuthorship W2106879049A5013428765 @default.
• W2106879049 hasAuthorship W2106879049A5030603878 @default.
• W2106879049 hasAuthorship W2106879049A5035223402 @default.
• W2106879049 hasAuthorship W2106879049A5060835385 @default.
• W2106879049 hasAuthorship W2106879049A5064808545 @default.
• W2106879049 hasConcept C126322002 @default.
• W2106879049 hasConcept C142724271 @default.
• W2106879049 hasConcept C204787440 @default.
• W2106879049 hasConcept C27081682 @default.
• W2106879049 hasConcept C2776042228 @default.
• W2106879049 hasConcept C2776136866 @default.
• W2106879049 hasConcept C2776780178 @default.
• W2106879049 hasConcept C2776804153 @default.
• W2106879049 hasConcept C2776954882 @default.
• W2106879049 hasConcept C2778689640 @default.
• W2106879049 hasConcept C2991922776 @default.
• W2106879049 hasConcept C42219234 @default.
• W2106879049 hasConcept C71924100 @default.
• W2106879049 hasConceptScore W2106879049C126322002 @default.
• W2106879049 hasConceptScore W2106879049C142724271 @default.
• W2106879049 hasConceptScore W2106879049C204787440 @default.
• W2106879049 hasConceptScore W2106879049C27081682 @default.
• W2106879049 hasConceptScore W2106879049C2776042228 @default.
• W2106879049 hasConceptScore W2106879049C2776136866 @default.
• W2106879049 hasConceptScore W2106879049C2776780178 @default.
• W2106879049 hasConceptScore W2106879049C2776804153 @default.
• W2106879049 hasConceptScore W2106879049C2776954882 @default.
• W2106879049 hasConceptScore W2106879049C2778689640 @default.
• W2106879049 hasConceptScore W2106879049C2991922776 @default.
• W2106879049 hasConceptScore W2106879049C42219234 @default.
• W2106879049 hasConceptScore W2106879049C71924100 @default.
• W2106879049 hasIssue "1" @default.
• W2106879049 hasLocation W21068790491 @default.
• W2106879049 hasLocation W21068790492 @default.
• W2106879049 hasOpenAccess W2106879049 @default.
• W2106879049 hasPrimaryLocation W21068790491 @default.
• W2106879049 hasRelatedWork W2041776764 @default.
• W2106879049 hasRelatedWork W2054166715 @default.
• W2106879049 hasRelatedWork W2057973646 @default.
• W2106879049 hasRelatedWork W2092861518 @default.
• W2106879049 hasRelatedWork W2116336946 @default.
• W2106879049 hasRelatedWork W2146830701 @default.
• W2106879049 hasRelatedWork W2162130040 @default.
• W2106879049 hasRelatedWork W2295504875 @default.
• W2106879049 hasRelatedWork W2411233343 @default.
• W2106879049 hasRelatedWork W2413316204 @default.
• W2106879049 hasVolume "110" @default.

• next