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• W2106895423 startingPage "e1003174" @default.
• W2106895423 abstract "Many toxin-antitoxin operons are regulated by the toxin/antitoxin ratio by mechanisms collectively coined “conditional cooperativity”. Toxin and antitoxin form heteromers with different stoichiometric ratios, and the complex with the intermediate ratio works best as a transcription repressor. This allows transcription at low toxin level, strong repression at intermediate toxin level, and then again transcription at high toxin level. Such regulation has two interesting features; firstly, it provides a non-monotonous response to the concentration of one of the proteins, and secondly, it opens for ultra-sensitivity mediated by the sequestration of the functioning heteromers. We explore possible functions of conditional regulation in simple feedback motifs, and show that it can provide bistability for a wide range of parameters. We then demonstrate that the conditional cooperativity in toxin-antitoxin systems combined with the growth-inhibition activity of free toxin can mediate bistability between a growing state and a dormant state." @default.
• W2106895423 created "2016-06-24" @default.
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• W2106895423 date "2013-08-29" @default.
• W2106895423 modified "2023-10-16" @default.
• W2106895423 title "Conditional Cooperativity of Toxin - Antitoxin Regulation Can Mediate Bistability between Growth and Dormancy" @default.
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• W2106895423 doi "https://doi.org/10.1371/journal.pcbi.1003174" @default.
• W2106895423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3757081" @default.
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• W2106895423 hasPublicationYear "2013" @default.
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