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• W2106900546 abstract "The introduction of L-dopa (L-3,4-dihydroxyphenylalanine) therapy 40 years ago was a revolution in the treatment of patients with Parkinson s disease (PD). With time, however, the shortcomings of oral L-dopa medication became apparent, in particular the appearance of troublesome side effects, expressed as involuntary movements (dyskinesias) that developed over time in many patients. A gene therapy approach, aimed at restoring dopamine synthesis in the affected brain by viral vector delivery of genes that encode the dopamine-synthesizing enzymes, may offer a solution to this problem. Now, a team of French and UK researchers reports promising results in a nonhuman primate model of PD, paving the way for clinical trials of this enzyme-replacement approach." @default.
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• W2106900546 date "2009-10-14" @default.
• W2106900546 modified "2023-10-03" @default.
• W2106900546 title "Gene Therapy for Dopamine Replacement in Parkinsons Disease" @default.
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• W2106900546 doi "https://doi.org/10.1126/scitranslmed.3000350" @default.
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