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• W2106910870 abstract "ABSTRACT Herpes simplex virus VP16 and ICP0 mutants replicate efficiently in U2OS osteosarcoma cells but are restricted in other cell types. We previously showed that the restrictive phenotype is dominant in a transient cell fusion assay, suggesting that U2OS cells lack an antiviral mechanism present in other cells. Recent data indicate that unscheduled membrane fusion events can activate the expression of interferon-stimulated genes (ISGs) in fibroblasts, raising the possibility that our earlier results were due to a fusion-induced antiviral state. However, we show here that the permissive phenotype is also extinguished following fusion with Vero cells in the absence of ISG induction." @default.
• W2106910870 created "2016-06-24" @default.
• W2106910870 creator A5008024387 @default.
• W2106910870 creator A5015898479 @default.
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• W2106910870 date "2009-09-01" @default.
• W2106910870 modified "2023-09-26" @default.
• W2106910870 title "Cell Fusion-Induced Activation of Interferon-Stimulated Genes Is Not Required for Restriction of a Herpes Simplex Virus VP16/ICP0 Mutant in Heterokarya Formed between Permissive and Restrictive Cells" @default.
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• W2106910870 doi "https://doi.org/10.1128/jvi.00142-09" @default.
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