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- W2106918488 abstract "Identifying the functions of uncharacterised genes is one of the challenges in bioinformatics. Numerous solutions have been proposed for the problem. This work will outline one possible technique for identifying genes responsible for a developmental process in the mouse embryo. Our approach consists of analysing the co-expression of genes in different tissues which where we know a particular process is happening. We derive our data from GXD and annotate them with Biological Process terms using the Gene Ontology. Finally we analyse the significance of each term in order to create a functional view of our co-expressed genes. We focus on a process that is little understood in the current literature, the mesenchymal to epithelial transformation of cells. Yet our approach is theoretically feasible for any other biological process that occurs in several tissues of an arbitrary organism during its developmental or gestation period. Although our methods were proved unable to isolate the set of genes that are responsible for the mesenchyme-epithelial process, we obtained a number of interesting results. The principle validity of our approach and the underlying hypothesis remains questionable. However, the project succeeded in finding numerous candidate genes for our process of interest, which could be worth subjecting to more rigorous biological experimentation and analysis." @default.
- W2106918488 created "2016-06-24" @default.
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- W2106918488 date "2007-01-01" @default.
- W2106918488 modified "2023-09-24" @default.
- W2106918488 title "An Ontological Approach to Analysing Developmental Processes in the Mouse Based on Co-Expression" @default.
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