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• W2106919187 abstract "In the amphibian Xenopus laevis, the elongation factor 1α proteins (EF-1α) synthesised in oocytes and somatic cells correspond to distinct gene products. Furthermore, the somatic EF-1α gene (EF-1αS) produces one of the most highly expressed early zygotic transcripts in the embryo. The functional recycling of EF-1α (conversion of EF-1α-GDP to EF-1α-GTP) is assured by the EF-1βγ complex. We show here that in Xenopus laevis embryos, contrary to the situation for EF-1α, EF-1β, and EF-1γ mRNAs are transcribed from the same genes in oocytes and somatic cells. In addition, the onset of transcription of the EF-1β and EF-1γ genes from the zygotic gencme occurs several hours after that of the somatic EF-1αS gene. Therefore, during early Xenopus development the expression of these three elongation factors is not co-ordinated at the transcriptional level. The consequences of this uncoupling on the efficiency of translational elongation in the early Xenopus embryo are discussed. © 1993 Wiley-Liss, Inc." @default.
• W2106919187 created "2016-06-24" @default.
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• W2106919187 date "1993-01-01" @default.
• W2106919187 modified "2023-09-30" @default.
• W2106919187 title "Expression of elongation factor 1α (EF-1α) and 1βγ (EF-1βγ) are uncoupled in earlyXenopus embryos" @default.
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• W2106919187 doi "https://doi.org/10.1002/dvg.1020140605" @default.
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