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- W2106936897 abstract "Oxybutynin is rapidly metabolized in rat liver microsomes. Two major primary oxidation products were identified as N-desethyl oxybutynin and oxybutynin N-oxide. Deuterium substituted substrate was used to aid the identification. N-Desethyl oxybutynin was characterized by gas chromatography electron impact mass spectrometry as its trifluoroacetamide derivative and oxybutynin N-oxide was indicated by the presence of a decomposition product, 2-oxo-3-butenyl-2 cyclohexyl-2-phenylglycolate, as elucidated from the gas chromatographic mass spectrometric analysis. The formation of this product from synthetic oxybutynin N-oxide was verified and occurs by two consecutive rearrangements upon thermolysis of the unstable N-oxide. Attempted titanous chloride reduction of oxybutynin N-oxide resulted in the formation of the hydrolytic products 2-cyclohexyl-2-phenylglycolic acid and 4-diethylamino-2-butynol." @default.
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- W2106936897 date "1981-10-01" @default.
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- W2106936897 title "Metabolism of oxybutynin: Establishment of desethyloxybutynin and oxybutyninN-oxide formation in rat liver preparations using deuterium substitution and gas chromatographic mass spectrometric analysis" @default.
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- W2106936897 doi "https://doi.org/10.1002/bms.1200081009" @default.
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