FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106979103> ?p ?o ?g. }

• W2106979103 endingPage "929" @default.
• W2106979103 startingPage "919" @default.
• W2106979103 abstract "The bacterial ATPase SecA and protein channel complex SecYEG form the core of an essential protein translocation machinery. The nature of the conformational changes induced by each stage of the hydrolytic cycle of ATP and how they are coupled to protein translocation are not well understood. The structure of the SecA-SecYEG complex revealed a 2-helix-finger (2HF) of SecA in an ideal position to contact the substrate protein and push it through the membrane. Surprisingly, immobilization of this finger at the edge of the protein channel had no effect on translocation, whereas its imposition inside the channel blocked transport. This analysis resolves the stoichiometry of the active complex, demonstrating that after the initiation process translocation requires only one copy each of SecA and SecYEG. The results also have important implications on the mechanism of energy transduction and the power stroke driving transport. Evidently, the 2HF is not a highly mobile transducing element of polypeptide translocation." @default.
• W2106979103 created "2016-06-24" @default.
• W2106979103 creator A5001328340 @default.
• W2106979103 creator A5003028957 @default.
• W2106979103 creator A5032661199 @default.
• W2106979103 creator A5043806384 @default.
• W2106979103 creator A5084166211 @default.
• W2106979103 creator A5088764394 @default.
• W2106979103 date "2012-12-03" @default.
• W2106979103 modified "2023-10-16" @default.
• W2106979103 title "Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex" @default.
• W2106979103 cites W1968636401 @default.
• W2106979103 cites W1971305098 @default.
• W2106979103 cites W1974721122 @default.
• W2106979103 cites W1981526758 @default.
• W2106979103 cites W1983472367 @default.
• W2106979103 cites W1986246745 @default.
• W2106979103 cites W2007313234 @default.
• W2106979103 cites W2007432423 @default.
• W2106979103 cites W2008223866 @default.
• W2106979103 cites W2008415333 @default.
• W2106979103 cites W2021878227 @default.
• W2106979103 cites W2034878432 @default.
• W2106979103 cites W2039311296 @default.
• W2106979103 cites W2044775677 @default.
• W2106979103 cites W2053834896 @default.
• W2106979103 cites W2055998978 @default.
• W2106979103 cites W2073726493 @default.
• W2106979103 cites W2077333037 @default.
• W2106979103 cites W2078643939 @default.
• W2106979103 cites W2079467523 @default.
• W2106979103 cites W2081260116 @default.
• W2106979103 cites W2094624515 @default.
• W2106979103 cites W2098956194 @default.
• W2106979103 cites W2103211563 @default.
• W2106979103 cites W2105771181 @default.
• W2106979103 cites W2110459288 @default.
• W2106979103 cites W2112382738 @default.
• W2106979103 cites W2130847860 @default.
• W2106979103 cites W2147803352 @default.
• W2106979103 cites W2151058276 @default.
• W2106979103 cites W2152442148 @default.
• W2106979103 cites W2152697562 @default.
• W2106979103 cites W2155234325 @default.
• W2106979103 cites W2155924407 @default.
• W2106979103 cites W2163367174 @default.
• W2106979103 cites W2170743627 @default.
• W2106979103 doi "https://doi.org/10.1083/jcb.201205191" @default.
• W2106979103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3518217" @default.
• W2106979103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23209305" @default.
• W2106979103 hasPublicationYear "2012" @default.
• W2106979103 type Work @default.
• W2106979103 sameAs 2106979103 @default.
• W2106979103 citedByCount "48" @default.
• W2106979103 countsByYear W21069791032013 @default.
• W2106979103 countsByYear W21069791032014 @default.
• W2106979103 countsByYear W21069791032015 @default.
• W2106979103 countsByYear W21069791032016 @default.
• W2106979103 countsByYear W21069791032017 @default.
• W2106979103 countsByYear W21069791032018 @default.
• W2106979103 countsByYear W21069791032019 @default.
• W2106979103 countsByYear W21069791032020 @default.
• W2106979103 countsByYear W21069791032021 @default.
• W2106979103 countsByYear W21069791032022 @default.
• W2106979103 countsByYear W21069791032023 @default.
• W2106979103 crossrefType "journal-article" @default.
• W2106979103 hasAuthorship W2106979103A5001328340 @default.
• W2106979103 hasAuthorship W2106979103A5003028957 @default.
• W2106979103 hasAuthorship W2106979103A5032661199 @default.
• W2106979103 hasAuthorship W2106979103A5043806384 @default.
• W2106979103 hasAuthorship W2106979103A5084166211 @default.
• W2106979103 hasAuthorship W2106979103A5088764394 @default.
• W2106979103 hasBestOaLocation W21069791031 @default.
• W2106979103 hasConcept C104317684 @default.
• W2106979103 hasConcept C115335371 @default.
• W2106979103 hasConcept C12554922 @default.
• W2106979103 hasConcept C138626823 @default.
• W2106979103 hasConcept C141315368 @default.
• W2106979103 hasConcept C144647389 @default.
• W2106979103 hasConcept C181199279 @default.
• W2106979103 hasConcept C18903297 @default.
• W2106979103 hasConcept C20418707 @default.
• W2106979103 hasConcept C23265538 @default.
• W2106979103 hasConcept C2778530040 @default.
• W2106979103 hasConcept C2779965526 @default.
• W2106979103 hasConcept C41625074 @default.
• W2106979103 hasConcept C55493867 @default.
• W2106979103 hasConcept C57581600 @default.
• W2106979103 hasConcept C86803240 @default.
• W2106979103 hasConcept C93126451 @default.
• W2106979103 hasConcept C95444343 @default.
• W2106979103 hasConceptScore W2106979103C104317684 @default.
• W2106979103 hasConceptScore W2106979103C115335371 @default.
• W2106979103 hasConceptScore W2106979103C12554922 @default.
• W2106979103 hasConceptScore W2106979103C138626823 @default.
• W2106979103 hasConceptScore W2106979103C141315368 @default.
• W2106979103 hasConceptScore W2106979103C144647389 @default.
• W2106979103 hasConceptScore W2106979103C181199279 @default.

• next