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- W2106979968 abstract "Radioimmunotherapy based on α-particle emitters has excellent properties as a treatment against micrometastatic and disseminated cancers because of the short path length (50 - 80 μm) and high linear energy transfer (∼ 100 keV/ μm). Alpha-particles produce clustered DNA double-strand breaks and highly reactive hydroxyl radicals when hitting biological tissue. Hence, targeted α-particle therapy offers the potential of selective tumor cell killing with low damage to surrounding normal tissue. The ideal applications for targeted α-therapy are in treating neoplastic cells in circulation or when cancer cells are present as free-floating cells or spread along compartment walls. This review will provide a brief overview of the most promising radionuclides for targeted α-therapy and compare their relative biological effectiveness (RBE) and normal tissue toxicity." @default.
- W2106979968 created "2016-06-24" @default.
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- W2106979968 date "2011-10-01" @default.
- W2106979968 modified "2023-10-13" @default.
- W2106979968 title "Toxicity and Relative Biological Effectiveness of Alpha Emitting Radioimmunoconjugates" @default.
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- W2106979968 doi "https://doi.org/10.2174/1874471011104040321" @default.
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