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- W2106982823 abstract "For the first time in history, worldwide neglected disease budgets may be large enough to deliver a new drug every few years. That said, sponsors will only succeed if they extract maximum value from every dollar spent. This paper reviews possible cost-containment strategies and provides an evidence-based framework for choosing between them. Current proposals can be categorized as end-to-end proposals which require the sponsor to set a single reward for companies that complete the entire drug discovery process or pay-as-you-go schemes in which sponsors offer repeated rewards as drug candidates progress through the pipeline. A generic weakness of end-to-end proposals is that rewards are likely to be 20-30% higher than they would be in an equivalent pay-as-you-go programme. However, the benefits of pay-as-you-go programmes may be lost if commercial pharmaceutical companies are substantially better at choosing successful programmes than are their non-profit counterparts. The efficiency of pay-as-you-go methods depends on sponsors' willingness to withdraw funding from failed drug discovery programmes." @default.
- W2106982823 created "2016-06-24" @default.
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- W2106982823 date "2006-05-01" @default.
- W2106982823 modified "2023-10-18" @default.
- W2106982823 title "Choosing the right incentive strategy for research and development in neglected diseases" @default.
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- W2106982823 doi "https://doi.org/10.2471/blt.06.029835" @default.
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