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- W2106996018 abstract "A simple method is described for the rapid, quantitative analysis of caffeine in human plasma. Caffeine levels present in plasma following drug administration were determined by high-performance liquid chromatography with UV detection at 273 nm after plasma protein precipitation. Caffeine was detectable at levels as low as 0.1 micrograms/mL. Mean recoveries of 98% with a coefficient of variation of 3% were obtained for plasma standards, in which concentrations ranged from 0.1 to 8 micrograms/mL. Interassay variability of the slope of the standard curve had a coefficient of variation of 3%. Application of this method during human bioavailability studies is described." @default.
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- W2106996018 date "1984-07-01" @default.
- W2106996018 modified "2023-10-17" @default.
- W2106996018 title "Rapid Quantitative Liquid Chromatographic Determination of Caffeine Levels in Plasma after Oral Dosing" @default.
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- W2106996018 doi "https://doi.org/10.1002/jps.2600730742" @default.
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