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- W2107002000 abstract "The contribution of the ATP-sensitive K+ (K ATP +) current to the action potential is an important component of cardiac ischaemia. The purpose of this study was to investigate how the formulation of I K(ATP) influences action potential shape and duration in the Ten Tusscher-Panfilov 2006 model of human ventricular myocytes. We compared four different I K(ATP) formulations, which were inserted in the epicardial variant of the cell model embedded in a 2D monodomain tissue model. The results demonstrate that inserting I K(ATP) in the cell models shortens APD as intracellular ATP concentration is reduced, consistent with experimental findings. Although the current-voltage properties of each I K(ATP) formulation were different, each formulation had a similar effect on the properties of the tissue model." @default.
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- W2107002000 date "2014-09-01" @default.
- W2107002000 modified "2023-09-26" @default.
- W2107002000 title "Formulation of ATP sensitive K + current and action potential shape in models of human ventricular myocytes" @default.
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