Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107003308> ?p ?o ?g. }
- W2107003308 endingPage "341" @default.
- W2107003308 startingPage "328" @default.
- W2107003308 abstract "The overall neurobiological mechanisms by which lithium and valproate stabilize mood in bipolar disorder patients have yet to be fully defined. The therapeutic efficacy and dissimilar chemical structures of these medications suggest that they perturb both shared and disparate cellular processes. To investigate key pathways and functional clusters involved in the global action of lithium and valproate, we generated interaction networks formed by well-supported drug targets. Striking functional similarities emerged. Intersecting nodes in lithium and valproate networks highlighted a strong enrichment of apoptosis clusters and neurotrophin signaling. Other enriched pathways included MAPK, ErbB, insulin, VEGF, Wnt and long-term potentiation indicating a widespread effect of both drugs on diverse signaling systems. MAPK1/3 and AKT1/2 were the most preponderant nodes across pathways suggesting a central role in mediating pathway interactions. The convergence of biological responses unveils a functional signature for lithium and valproate that could be key modulators of their therapeutic efficacy." @default.
- W2107003308 created "2016-06-24" @default.
- W2107003308 creator A5000279312 @default.
- W2107003308 creator A5007177088 @default.
- W2107003308 creator A5021363787 @default.
- W2107003308 creator A5022793691 @default.
- W2107003308 creator A5038738280 @default.
- W2107003308 creator A5041991034 @default.
- W2107003308 creator A5048653843 @default.
- W2107003308 creator A5048877098 @default.
- W2107003308 creator A5091418738 @default.
- W2107003308 date "2011-03-08" @default.
- W2107003308 modified "2023-10-16" @default.
- W2107003308 title "Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling" @default.
- W2107003308 cites W1927894522 @default.
- W2107003308 cites W1963612967 @default.
- W2107003308 cites W1964044507 @default.
- W2107003308 cites W1964617786 @default.
- W2107003308 cites W1967318257 @default.
- W2107003308 cites W1970840405 @default.
- W2107003308 cites W1970967627 @default.
- W2107003308 cites W1973675690 @default.
- W2107003308 cites W1974369164 @default.
- W2107003308 cites W1974415708 @default.
- W2107003308 cites W1975342044 @default.
- W2107003308 cites W1975922954 @default.
- W2107003308 cites W1976217193 @default.
- W2107003308 cites W1987908992 @default.
- W2107003308 cites W1989304353 @default.
- W2107003308 cites W1995540460 @default.
- W2107003308 cites W2000683036 @default.
- W2107003308 cites W2000715713 @default.
- W2107003308 cites W2005887344 @default.
- W2107003308 cites W2006562902 @default.
- W2107003308 cites W2006677458 @default.
- W2107003308 cites W2007188652 @default.
- W2107003308 cites W2012094764 @default.
- W2107003308 cites W2014596655 @default.
- W2107003308 cites W2015345074 @default.
- W2107003308 cites W2015671416 @default.
- W2107003308 cites W2018943698 @default.
- W2107003308 cites W2020237866 @default.
- W2107003308 cites W2020370875 @default.
- W2107003308 cites W2024493236 @default.
- W2107003308 cites W2024709318 @default.
- W2107003308 cites W2027692631 @default.
- W2107003308 cites W2033758245 @default.
- W2107003308 cites W2034753731 @default.
- W2107003308 cites W2036604724 @default.
- W2107003308 cites W2039196318 @default.
- W2107003308 cites W2040144923 @default.
- W2107003308 cites W2047073581 @default.
- W2107003308 cites W2048228571 @default.
- W2107003308 cites W2048335778 @default.
- W2107003308 cites W2051788298 @default.
- W2107003308 cites W2053045480 @default.
- W2107003308 cites W2058073758 @default.
- W2107003308 cites W2058413487 @default.
- W2107003308 cites W2063125237 @default.
- W2107003308 cites W2067961999 @default.
- W2107003308 cites W2068388603 @default.
- W2107003308 cites W2071378588 @default.
- W2107003308 cites W2072469560 @default.
- W2107003308 cites W2073264699 @default.
- W2107003308 cites W2078246734 @default.
- W2107003308 cites W2079318542 @default.
- W2107003308 cites W2082656717 @default.
- W2107003308 cites W2084164174 @default.
- W2107003308 cites W2084480427 @default.
- W2107003308 cites W2085968319 @default.
- W2107003308 cites W2090599569 @default.
- W2107003308 cites W2093688721 @default.
- W2107003308 cites W2098249941 @default.
- W2107003308 cites W2103232698 @default.
- W2107003308 cites W2104411593 @default.
- W2107003308 cites W2107116316 @default.
- W2107003308 cites W2107450703 @default.
- W2107003308 cites W2110601338 @default.
- W2107003308 cites W2114228709 @default.
- W2107003308 cites W2114272370 @default.
- W2107003308 cites W2116488560 @default.
- W2107003308 cites W2117052065 @default.
- W2107003308 cites W2117691193 @default.
- W2107003308 cites W2119336730 @default.
- W2107003308 cites W2120005154 @default.
- W2107003308 cites W2120697942 @default.
- W2107003308 cites W2126613337 @default.
- W2107003308 cites W2127442418 @default.
- W2107003308 cites W2129768414 @default.
- W2107003308 cites W2129983577 @default.
- W2107003308 cites W2132596780 @default.
- W2107003308 cites W2135442608 @default.
- W2107003308 cites W2135772494 @default.
- W2107003308 cites W2138231319 @default.
- W2107003308 cites W2139397258 @default.
- W2107003308 cites W2139434433 @default.
- W2107003308 cites W2142469123 @default.
- W2107003308 cites W2146918064 @default.