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• W2107003688 abstract "The mechanisms underlying reduced red blood cell (RBC) deformability during Plasmodium falciparum (Pf) malaria remain poorly understood. Here, we explore the possible involvement of the L-arginine and nitric oxide (NO) pathway on RBC deformability in Pf-infected patients and parasite cultures. RBC deformability was reduced during the acute attack (day0) and returned to normal values upon convalescence (day28). Day0 values correlated with plasma L-arginine levels (r = 0.69; p = 0.01) and weakly with parasitemia (r = -0.38; p = 0.006). In vitro, day0 patient's plasma incubated with ring-stage cultures at 41°C reduced RBC deformability, and this effect correlated strongly with plasma L-arginine levels (r = 0.89; p < 0.0001). Moreover, addition of exogenous L-arginine to the cultures increased deformability of both Pf-free and trophozoite-harboring RBCs. NO synthase activity, evidenced in Pf-infected RBCs, induced L-arginine-dependent NO production. These data show that hypoargininemia during P. falciparum malaria may altogether impair NO production and reduce RBC deformability, particularly at febrile temperature." @default.
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• W2107003688 date "2014-01-20" @default.
• W2107003688 modified "2023-10-18" @default.
• W2107003688 title "Reduced erythrocyte deformability associated with hypoargininemia during Plasmodiumfalciparum malaria" @default.
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• W2107003688 doi "https://doi.org/10.1038/srep03767" @default.
• W2107003688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3895919" @default.
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• W2107003688 hasPublicationYear "2014" @default.
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