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- W2107004061 abstract "Histamine is an important mediator of allergic responses. Arthropods express several biologically active proteins in their saliva, which may allow a prolonged blood meal on the host. Proteins identified and expressed include histamine, serotonin, tryptase, and complement binding proteins. We review here data that scavenging of endogenous histamine by the histamine-binding protein EV131 has a profound inhibitory effect on allergic asthma. Aerosol administration of EV131 prevented airway hyperreactivity and abrogated peribronchial inflammation, eosinophil recruitment, mucus hypersecretion, and IL-4 and IL-5 secretion. Saturation with histamine abrogated the inhibitory effect of EV131 on bronchial hyperreactivity. The data suggest that histamine plays a role in allergies and that scavenging of histamine by EV131 may represent a novel therapeutic strategy in the treatment of allergic diseases." @default.
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- W2107004061 date "2005-11-01" @default.
- W2107004061 modified "2023-09-25" @default.
- W2107004061 title "Arthropod-Derived Protein EV131 Inhibits Histamine Action and Allergic Asthma" @default.
- W2107004061 doi "https://doi.org/10.1196/annals.1352.009" @default.
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