Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107004469> ?p ?o ?g. }
- W2107004469 endingPage "487" @default.
- W2107004469 startingPage "478" @default.
- W2107004469 abstract "Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, characterized by irreversible decline of mental faculties, emotional and behavioral changes, loss of motor skills, and dysfunction of autonomic nervous system and disruption of circadian rhythms (CRs). We attempted to describe the morphological findings of the hypothalamus in early cases of AD, focusing our study mostly on the suprachiasmatic nucleus (SCN), the supraoptic nucleus (SON), and the paraventricular nucleus (PVN). Samples were processed for electron microscopy and silver impregnation techniques. The hypothalamic nuclei demonstrated a substantial decrease in the neuronal population, which was particularly prominent in the SCN. Marked abbreviation of dendritic arborization, in association with spinal pathology, was also seen. The SON and PVN demonstrated a substantial number of dystrophic axons and abnormal spines. Alzheimer’s pathology, such as deposits of amyloid-β peptide and neurofibrillary degeneration, was minimal. Electron microscopy revealed mitochondrial alterations in the cell body and the dendritic branches. The morphological alterations of the hypothalamic nuclei in early cases of AD may be related to the gradual alteration of CRs and the instability of autonomic regulation." @default.
- W2107004469 created "2016-06-24" @default.
- W2107004469 creator A5000305450 @default.
- W2107004469 creator A5009297212 @default.
- W2107004469 creator A5022695536 @default.
- W2107004469 creator A5040900441 @default.
- W2107004469 creator A5084523497 @default.
- W2107004469 date "2014-11-07" @default.
- W2107004469 modified "2023-10-17" @default.
- W2107004469 title "The Hypothalamus in Alzheimer’s Disease" @default.
- W2107004469 cites W120353134 @default.
- W2107004469 cites W1411416414 @default.
- W2107004469 cites W1514563261 @default.
- W2107004469 cites W1549400362 @default.
- W2107004469 cites W1563590122 @default.
- W2107004469 cites W1709291651 @default.
- W2107004469 cites W1867176171 @default.
- W2107004469 cites W1965352353 @default.
- W2107004469 cites W1967094886 @default.
- W2107004469 cites W1967347174 @default.
- W2107004469 cites W1970269823 @default.
- W2107004469 cites W1978611788 @default.
- W2107004469 cites W1986165256 @default.
- W2107004469 cites W1986980390 @default.
- W2107004469 cites W1990411503 @default.
- W2107004469 cites W1993571512 @default.
- W2107004469 cites W1994060945 @default.
- W2107004469 cites W1994268409 @default.
- W2107004469 cites W1995821999 @default.
- W2107004469 cites W1998477647 @default.
- W2107004469 cites W2000631168 @default.
- W2107004469 cites W2005944189 @default.
- W2107004469 cites W2007047564 @default.
- W2107004469 cites W2008888319 @default.
- W2107004469 cites W2010395737 @default.
- W2107004469 cites W2010839420 @default.
- W2107004469 cites W2011308923 @default.
- W2107004469 cites W2016069734 @default.
- W2107004469 cites W2016139827 @default.
- W2107004469 cites W2016429383 @default.
- W2107004469 cites W2017465880 @default.
- W2107004469 cites W2021826685 @default.
- W2107004469 cites W2022637707 @default.
- W2107004469 cites W2024414157 @default.
- W2107004469 cites W2032923900 @default.
- W2107004469 cites W2034831738 @default.
- W2107004469 cites W2035345007 @default.
- W2107004469 cites W2035421865 @default.
- W2107004469 cites W2037904566 @default.
- W2107004469 cites W2039697052 @default.
- W2107004469 cites W2045948521 @default.
- W2107004469 cites W2047507940 @default.
- W2107004469 cites W2049010378 @default.
- W2107004469 cites W2055672184 @default.
- W2107004469 cites W2056734213 @default.
- W2107004469 cites W2057013121 @default.
- W2107004469 cites W2057662501 @default.
- W2107004469 cites W2060565819 @default.
- W2107004469 cites W2063678099 @default.
- W2107004469 cites W2068976528 @default.
- W2107004469 cites W2073777391 @default.
- W2107004469 cites W2074274706 @default.
- W2107004469 cites W2076665460 @default.
- W2107004469 cites W2079760721 @default.
- W2107004469 cites W2082685144 @default.
- W2107004469 cites W2086780496 @default.
- W2107004469 cites W2087513719 @default.
- W2107004469 cites W2093431290 @default.
- W2107004469 cites W2098244868 @default.
- W2107004469 cites W2106336538 @default.
- W2107004469 cites W2106538949 @default.
- W2107004469 cites W2106875648 @default.
- W2107004469 cites W2119354691 @default.
- W2107004469 cites W2123677150 @default.
- W2107004469 cites W2124955411 @default.
- W2107004469 cites W2137944397 @default.
- W2107004469 cites W2138535592 @default.
- W2107004469 cites W2141551430 @default.
- W2107004469 cites W2143210222 @default.
- W2107004469 cites W2145859760 @default.
- W2107004469 cites W2149821586 @default.
- W2107004469 cites W2152165298 @default.
- W2107004469 cites W2154900811 @default.
- W2107004469 cites W2156220037 @default.
- W2107004469 cites W2158649743 @default.
- W2107004469 cites W2159529587 @default.
- W2107004469 cites W2162142126 @default.
- W2107004469 cites W2166930817 @default.
- W2107004469 cites W2168681379 @default.
- W2107004469 cites W2427327051 @default.
- W2107004469 cites W4232271414 @default.
- W2107004469 cites W4243693606 @default.
- W2107004469 cites W4245067825 @default.
- W2107004469 cites W48248669 @default.
- W2107004469 cites W88308794 @default.
- W2107004469 doi "https://doi.org/10.1177/1533317514556876" @default.
- W2107004469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25380804" @default.
- W2107004469 hasPublicationYear "2014" @default.