FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107022019> ?p ?o ?g. }

• W2107022019 endingPage "259" @default.
• W2107022019 startingPage "251" @default.
• W2107022019 abstract "The global prevalence of HIV is a major challenge for control of visceral leishmaniasis, a disseminated protozoan infection. In some east African regions, up to 40% of patients with visceral leishmaniasis are co-infected with HIV. Management of visceral leishmaniasis in such patients is complicated by treatment failures and relapses, even while patients are receiving standard antiretroviral therapy. In-vitro studies have consistently documented an inhibitory effect of specific HIV-1 protease inhibitors on leishmania parasites, and the underlying mechanism is partly explained. With the global scaling up of HIV treatment, HIV-1 protease inhibitors are increasingly becoming available for second-line HIV treatment in regions where visceral leishmaniasis and HIV are endemic. However, additional research is needed before HIV-1 protease inhibitors can be taken forward for clinical use against visceral leishmaniasis in HIV-infected patients. Since the effect of protease inhibitors against Leishmania species was generally observed at high drug concentrations, efficacy and dose–response relationships should be studied in animals before these drugs are used in clinical trials. More extensive studies of all available HIV protease inhibitors are needed, including investigation of drug interactions and emergence of drug-resistant parasites. In addition to exploring the full potential of current HIV-1 protease inhibitors against visceral leishmaniasis, leishmania-specific protease inhibitors should be developed." @default.
• W2107022019 created "2016-06-24" @default.
• W2107022019 creator A5006896277 @default.
• W2107022019 creator A5008098933 @default.
• W2107022019 creator A5027677067 @default.
• W2107022019 creator A5028128458 @default.
• W2107022019 creator A5045317610 @default.
• W2107022019 creator A5048578558 @default.
• W2107022019 creator A5054138064 @default.
• W2107022019 creator A5075179338 @default.
• W2107022019 date "2013-03-01" @default.
• W2107022019 modified "2023-10-16" @default.
• W2107022019 title "HIV-1 protease inhibitors for treatment of visceral leishmaniasis in HIV-co-infected individuals" @default.
• W2107022019 cites W118179764 @default.
• W2107022019 cites W1565516993 @default.
• W2107022019 cites W1600359904 @default.
• W2107022019 cites W1972489358 @default.
• W2107022019 cites W1983000152 @default.
• W2107022019 cites W1983840207 @default.
• W2107022019 cites W1985837899 @default.
• W2107022019 cites W1990969484 @default.
• W2107022019 cites W1991321426 @default.
• W2107022019 cites W1992503089 @default.
• W2107022019 cites W1997784624 @default.
• W2107022019 cites W2003451501 @default.
• W2107022019 cites W2007989984 @default.
• W2107022019 cites W2019523902 @default.
• W2107022019 cites W2023902449 @default.
• W2107022019 cites W2024789710 @default.
• W2107022019 cites W2034793318 @default.
• W2107022019 cites W2035095394 @default.
• W2107022019 cites W2038565126 @default.
• W2107022019 cites W2039344845 @default.
• W2107022019 cites W2044748199 @default.
• W2107022019 cites W2049261142 @default.
• W2107022019 cites W2056751317 @default.
• W2107022019 cites W2061397966 @default.
• W2107022019 cites W2067446305 @default.
• W2107022019 cites W2071428342 @default.
• W2107022019 cites W2080603087 @default.
• W2107022019 cites W2084752824 @default.
• W2107022019 cites W2088081864 @default.
• W2107022019 cites W2091837929 @default.
• W2107022019 cites W2094775674 @default.
• W2107022019 cites W2107915297 @default.
• W2107022019 cites W2112697477 @default.
• W2107022019 cites W2112953422 @default.
• W2107022019 cites W2117744918 @default.
• W2107022019 cites W2117860338 @default.
• W2107022019 cites W2119433625 @default.
• W2107022019 cites W2119749072 @default.
• W2107022019 cites W2124286005 @default.
• W2107022019 cites W2127691252 @default.
• W2107022019 cites W2132674987 @default.
• W2107022019 cites W2136269153 @default.
• W2107022019 cites W2138048624 @default.
• W2107022019 cites W2140299661 @default.
• W2107022019 cites W2140534639 @default.
• W2107022019 cites W2150351369 @default.
• W2107022019 cites W2154324414 @default.
• W2107022019 cites W2156382913 @default.
• W2107022019 cites W2165142588 @default.
• W2107022019 cites W2166169555 @default.
• W2107022019 cites W4240133843 @default.
• W2107022019 doi "https://doi.org/10.1016/s1473-3099(12)70348-1" @default.
• W2107022019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23427890" @default.
• W2107022019 hasPublicationYear "2013" @default.
• W2107022019 type Work @default.
• W2107022019 sameAs 2107022019 @default.
• W2107022019 citedByCount "36" @default.
• W2107022019 countsByYear W21070220192013 @default.
• W2107022019 countsByYear W21070220192014 @default.
• W2107022019 countsByYear W21070220192015 @default.
• W2107022019 countsByYear W21070220192016 @default.
• W2107022019 countsByYear W21070220192017 @default.
• W2107022019 countsByYear W21070220192018 @default.
• W2107022019 countsByYear W21070220192019 @default.
• W2107022019 countsByYear W21070220192021 @default.
• W2107022019 countsByYear W21070220192022 @default.
• W2107022019 countsByYear W21070220192023 @default.
• W2107022019 crossrefType "journal-article" @default.
• W2107022019 hasAuthorship W2107022019A5006896277 @default.
• W2107022019 hasAuthorship W2107022019A5008098933 @default.
• W2107022019 hasAuthorship W2107022019A5027677067 @default.
• W2107022019 hasAuthorship W2107022019A5028128458 @default.
• W2107022019 hasAuthorship W2107022019A5045317610 @default.
• W2107022019 hasAuthorship W2107022019A5048578558 @default.
• W2107022019 hasAuthorship W2107022019A5054138064 @default.
• W2107022019 hasAuthorship W2107022019A5075179338 @default.
• W2107022019 hasConcept C136764020 @default.
• W2107022019 hasConcept C142462285 @default.
• W2107022019 hasConcept C159047783 @default.
• W2107022019 hasConcept C181199279 @default.
• W2107022019 hasConcept C203014093 @default.
• W2107022019 hasConcept C2776555147 @default.
• W2107022019 hasConcept C2776714187 @default.
• W2107022019 hasConcept C2778689377 @default.
• W2107022019 hasConcept C2780035454 @default.

• next