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- W2107024907 abstract "Dialkylaminoalkyl esters of 4,4’-diphenyl propanedicarboxylic acid; 4,4 ’-dibenzyldi- carboxylic acid; 4,4,-diphenybnethanedicarboxylic acid; 4,4 ’-diphenyldicarboxylic acid, and terephthalic acid were prepared as the hydrochlorides and tested for local anesthetic activity on the rabbit cornea and by intradermal injection in the guinea pig.Acute toxicity was studied by intraperitoneal and intravenous injection in mice.No predictable relationship between local anesthetic activity and the size of the dicarboxylic acid nucleus was evident.Toxicity decreased as the methylene groups between the benzene rings was reduced.Two esters appeared to have greater local anesthetic activity and lower toxicity than procaine." @default.
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- W2107024907 date "1956-06-01" @default.
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- W2107024907 title "Effect of Alteration of Size of the Aromatic Dicarboxylic Acid Nucleus on Local Anesthetic Activity" @default.
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- W2107024907 doi "https://doi.org/10.1002/jps.3030450609" @default.
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