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- W2107025693 abstract "Ribosome biogenesis requires, in addition to rRNA molecules and ribosomal proteins, a multitude of trans-acting factors. Recently it has become clear that in the yeast Saccharomyces cerevisiae many RNA helicases of the DEAD-box and related families are involved in ribosome biogenesis. Here we show that the previously uncharacterised open reading frame YDL031w (renamed DBP10 for DEAD-box protein 10) encodes an essential putative RNA helicase that is required for accurate ribosome biogenesis. Genetic depletion of Dbp10p results in a deficit in 60S ribosomal subunits and an accumulation of half-mer polysomes. Furthermore, pulse-chase analyses of pre-rRNA processing reveal a strong delay in the maturation of 27SB pre-rRNA intermediates into 25S rRNA and 7S pre-rRNA. Northern blot analyses indicate that this delay leads to higher steady-state levels of 27SB species and reduced steady-state levels of 7S pre-rRNA and 25S/5.8S mature rRNAs, thus explaining the final deficit in 60S subunit and the formation of half-mer polysomes. Consistent with a direct role in ribosome biogenesis, Dbp10p was found to be located predominantly in the nucleolus." @default.
- W2107025693 created "2016-06-24" @default.
- W2107025693 creator A5079711251 @default.
- W2107025693 date "2000-06-15" @default.
- W2107025693 modified "2023-10-04" @default.
- W2107025693 title "Dbp10p, a putative RNA helicase from Saccharomyces cerevisiae, is required for ribosome biogenesis" @default.
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- W2107025693 doi "https://doi.org/10.1093/nar/28.12.2315" @default.
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