Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107028315> ?p ?o ?g. }
- W2107028315 endingPage "2687" @default.
- W2107028315 startingPage "2673" @default.
- W2107028315 abstract "p300 and CBP are general transcriptional coactivators implicated in different cellular processes, including regulation of the cell cycle, differentiation, tumorigenesis, and apoptosis. Posttranslational modifications such as phosphorylation are predicted to select a specific function of p300/CBP in these processes; however, the identification of the kinases that regulate p300/CBP activity in response to individual stimuli and the physiological significance of p300 phosphorylation have not been elucidated. Here we demonstrate that the cardiotoxic anticancer agent doxorubicin (adriamycin) induces the phosphorylation of p300 in primary neonatal cardiomyocytes. Hyperphosphorylation precedes the degradation of p300 and parallels apoptosis in response to doxorubicin. Doxorubicin-activated p38 kinases alpha and beta associate with p300 and are implicated in the phosphorylation-mediated degradation of p300, as pharmacological blockade of p38 prevents p300 degradation. p38 phosphorylates p300 in vitro at both the N and C termini of the protein, and enforced activation of p38 by the constitutively active form of its upstream kinase (MKK6EE) triggers p300 degradation. These data support the conclusion that p38 mitogen-activated protein kinase regulates p300 protein stability and function in cardiomyocytes undergoing apoptosis in response to doxorubicin." @default.
- W2107028315 created "2016-06-24" @default.
- W2107028315 creator A5056500282 @default.
- W2107028315 creator A5060652405 @default.
- W2107028315 creator A5074558279 @default.
- W2107028315 creator A5076216766 @default.
- W2107028315 date "2005-04-01" @default.
- W2107028315 modified "2023-10-16" @default.
- W2107028315 title "Phosphorylation-Dependent Degradation of p300 by Doxorubicin-Activated p38 Mitogen-Activated Protein Kinase in Cardiac Cells" @default.
- W2107028315 cites W1522997760 @default.
- W2107028315 cites W1534224609 @default.
- W2107028315 cites W1547617108 @default.
- W2107028315 cites W1548972556 @default.
- W2107028315 cites W1562190035 @default.
- W2107028315 cites W1565881767 @default.
- W2107028315 cites W1580129093 @default.
- W2107028315 cites W1664472327 @default.
- W2107028315 cites W1791035026 @default.
- W2107028315 cites W1846468431 @default.
- W2107028315 cites W1884928119 @default.
- W2107028315 cites W1900657670 @default.
- W2107028315 cites W1957494568 @default.
- W2107028315 cites W1967476432 @default.
- W2107028315 cites W1970546329 @default.
- W2107028315 cites W1970579406 @default.
- W2107028315 cites W1974963541 @default.
- W2107028315 cites W1981364887 @default.
- W2107028315 cites W1984334393 @default.
- W2107028315 cites W1990766685 @default.
- W2107028315 cites W1998707569 @default.
- W2107028315 cites W2001333805 @default.
- W2107028315 cites W2001399809 @default.
- W2107028315 cites W2002564316 @default.
- W2107028315 cites W2002705413 @default.
- W2107028315 cites W2003288227 @default.
- W2107028315 cites W2007797756 @default.
- W2107028315 cites W2007986629 @default.
- W2107028315 cites W2013671870 @default.
- W2107028315 cites W2016658367 @default.
- W2107028315 cites W2018452760 @default.
- W2107028315 cites W2019684500 @default.
- W2107028315 cites W2021787959 @default.
- W2107028315 cites W2024740537 @default.
- W2107028315 cites W2032731042 @default.
- W2107028315 cites W2036536995 @default.
- W2107028315 cites W2046314213 @default.
- W2107028315 cites W2048404789 @default.
- W2107028315 cites W2052863274 @default.
- W2107028315 cites W2053547821 @default.
- W2107028315 cites W2055503851 @default.
- W2107028315 cites W2058448611 @default.
- W2107028315 cites W2060630008 @default.
- W2107028315 cites W2061932825 @default.
- W2107028315 cites W2062809474 @default.
- W2107028315 cites W2063346793 @default.
- W2107028315 cites W2063877452 @default.
- W2107028315 cites W2065477683 @default.
- W2107028315 cites W2069254565 @default.
- W2107028315 cites W2075907691 @default.
- W2107028315 cites W2076276305 @default.
- W2107028315 cites W2086525709 @default.
- W2107028315 cites W2094182857 @default.
- W2107028315 cites W2094892715 @default.
- W2107028315 cites W2095859714 @default.
- W2107028315 cites W2098476791 @default.
- W2107028315 cites W2103774785 @default.
- W2107028315 cites W2107944043 @default.
- W2107028315 cites W2108723275 @default.
- W2107028315 cites W2109838780 @default.
- W2107028315 cites W2110061457 @default.
- W2107028315 cites W2110911902 @default.
- W2107028315 cites W2119370228 @default.
- W2107028315 cites W2122057254 @default.
- W2107028315 cites W2124126928 @default.
- W2107028315 cites W2133585105 @default.
- W2107028315 cites W2134579594 @default.
- W2107028315 cites W2148487263 @default.
- W2107028315 cites W2150200572 @default.
- W2107028315 cites W2154147940 @default.
- W2107028315 cites W2155645083 @default.
- W2107028315 cites W2166527628 @default.
- W2107028315 cites W2169183258 @default.
- W2107028315 cites W2248056767 @default.
- W2107028315 cites W4232264475 @default.
- W2107028315 cites W93023984 @default.
- W2107028315 doi "https://doi.org/10.1128/mcb.25.7.2673-2687.2005" @default.
- W2107028315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1061628" @default.
- W2107028315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15767673" @default.
- W2107028315 hasPublicationYear "2005" @default.
- W2107028315 type Work @default.
- W2107028315 sameAs 2107028315 @default.
- W2107028315 citedByCount "106" @default.
- W2107028315 countsByYear W21070283152012 @default.
- W2107028315 countsByYear W21070283152013 @default.
- W2107028315 countsByYear W21070283152014 @default.
- W2107028315 countsByYear W21070283152015 @default.
- W2107028315 countsByYear W21070283152016 @default.
- W2107028315 countsByYear W21070283152017 @default.