FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107039072> ?p ?o ?g. }

• W2107039072 endingPage "G503" @default.
• W2107039072 startingPage "G493" @default.
• W2107039072 abstract "Anion secretion by colonic epithelium is dependent on apical CFTR-mediated anion conductance and basolateral ion transport. In many tissues, the NKCC1 Na(+)-K(+)-2Cl(-) cotransporter mediates basolateral Cl(-) uptake. However, additional evidence suggests that the AE2 Cl(-)/HCO(3)(-) exchanger, when coupled with the NHE1 Na(+)/H(+) exchanger or a Na(+)-HCO(3)(-) cotransporter (NBC), contributes to HCO(3)(-) and/or Cl(-) uptake. To analyze the secretory functions of AE2 in proximal colon, short-circuit current (I(sc)) responses to cAMP and inhibitors of basolateral anion transporters were measured in muscle-stripped wild-type (WT) and AE2-null (AE2(-/-)) proximal colon. In physiological Ringer, the magnitude of cAMP-stimulated I(sc) was the same in WT and AE2(-/-) colon. However, the I(sc) response in AE2(-/-) colon exhibited increased sensitivity to the NKCC1 inhibitor bumetanide and decreased sensitivity to the distilbene derivative SITS (which inhibits AE2 and some NBCs), indicating that loss of AE2 results in a switch to increased NKCC1-supported anion secretion. Removal of HCO(3)(-) resulted in robust cAMP-stimulated I(sc) in both AE2(-/-) and WT colon that was largely mediated by NKCC1, whereas removal of Cl(-) resulted in sharply decreased cAMP-stimulated I(sc) in AE2(-/-) colon relative to WT controls. Inhibition of NHE1 had no effect on cAMP-stimulated I(sc) in AE2(-/-) colon but caused a switch to NKCC1-supported secretion in WT colon. Thus, in AE2(-/-) colon, Cl(-) secretion supported by basolateral NKCC1 is enhanced, whereas HCO(3)(-) secretion is diminished. These results show that AE2 is a component of the basolateral ion transport mechanisms that support anion secretion in the proximal colon." @default.
• W2107039072 created "2016-06-24" @default.
• W2107039072 creator A5003557813 @default.
• W2107039072 creator A5010967815 @default.
• W2107039072 creator A5014312110 @default.
• W2107039072 creator A5026068823 @default.
• W2107039072 creator A5032080967 @default.
• W2107039072 date "2010-04-01" @default.
• W2107039072 modified "2023-09-27" @default.
• W2107039072 title "AE2 Cl⁻/HCO₃⁻exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon" @default.
• W2107039072 cites W1506614618 @default.
• W2107039072 cites W1523913576 @default.
• W2107039072 cites W1536331357 @default.
• W2107039072 cites W1545629156 @default.
• W2107039072 cites W1549867499 @default.
• W2107039072 cites W1556777194 @default.
• W2107039072 cites W1587846921 @default.
• W2107039072 cites W1748590186 @default.
• W2107039072 cites W1749264334 @default.
• W2107039072 cites W1967055492 @default.
• W2107039072 cites W1977188111 @default.
• W2107039072 cites W1982929403 @default.
• W2107039072 cites W1997996757 @default.
• W2107039072 cites W2019326144 @default.
• W2107039072 cites W2019838705 @default.
• W2107039072 cites W2024666229 @default.
• W2107039072 cites W2032399860 @default.
• W2107039072 cites W2032564067 @default.
• W2107039072 cites W2032689444 @default.
• W2107039072 cites W2044435419 @default.
• W2107039072 cites W2045419222 @default.
• W2107039072 cites W2047304768 @default.
• W2107039072 cites W2051318454 @default.
• W2107039072 cites W2054895013 @default.
• W2107039072 cites W2069602983 @default.
• W2107039072 cites W2078226110 @default.
• W2107039072 cites W2087006496 @default.
• W2107039072 cites W2095433390 @default.
• W2107039072 cites W2096008617 @default.
• W2107039072 cites W2101219807 @default.
• W2107039072 cites W2107017864 @default.
• W2107039072 cites W2111635756 @default.
• W2107039072 cites W2118173888 @default.
• W2107039072 cites W2118527116 @default.
• W2107039072 cites W2126391420 @default.
• W2107039072 cites W2128968040 @default.
• W2107039072 cites W2132069035 @default.
• W2107039072 cites W2140342454 @default.
• W2107039072 cites W2144302045 @default.
• W2107039072 cites W2147595812 @default.
• W2107039072 cites W2151206192 @default.
• W2107039072 cites W2156223714 @default.
• W2107039072 cites W2158969453 @default.
• W2107039072 cites W2259277792 @default.
• W2107039072 cites W2260773538 @default.
• W2107039072 cites W2263807587 @default.
• W2107039072 cites W2395897801 @default.
• W2107039072 cites W2410682331 @default.
• W2107039072 cites W2416990819 @default.
• W2107039072 cites W4231349255 @default.
• W2107039072 cites W4248035914 @default.
• W2107039072 doi "https://doi.org/10.1152/ajpgi.00178.2009" @default.
• W2107039072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2853300" @default.
• W2107039072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20110461" @default.
• W2107039072 hasPublicationYear "2010" @default.
• W2107039072 type Work @default.
• W2107039072 sameAs 2107039072 @default.
• W2107039072 citedByCount "41" @default.
• W2107039072 countsByYear W21070390722012 @default.
• W2107039072 countsByYear W21070390722013 @default.
• W2107039072 countsByYear W21070390722014 @default.
• W2107039072 countsByYear W21070390722015 @default.
• W2107039072 countsByYear W21070390722016 @default.
• W2107039072 countsByYear W21070390722017 @default.
• W2107039072 countsByYear W21070390722018 @default.
• W2107039072 countsByYear W21070390722020 @default.
• W2107039072 countsByYear W21070390722021 @default.
• W2107039072 crossrefType "journal-article" @default.
• W2107039072 hasAuthorship W2107039072A5003557813 @default.
• W2107039072 hasAuthorship W2107039072A5010967815 @default.
• W2107039072 hasAuthorship W2107039072A5014312110 @default.
• W2107039072 hasAuthorship W2107039072A5026068823 @default.
• W2107039072 hasAuthorship W2107039072A5032080967 @default.
• W2107039072 hasBestOaLocation W21070390722 @default.
• W2107039072 hasConcept C104317684 @default.
• W2107039072 hasConcept C114574056 @default.
• W2107039072 hasConcept C120405084 @default.
• W2107039072 hasConcept C12554922 @default.
• W2107039072 hasConcept C149011108 @default.
• W2107039072 hasConcept C178790620 @default.
• W2107039072 hasConcept C185592680 @default.
• W2107039072 hasConcept C188053792 @default.
• W2107039072 hasConcept C2778212192 @default.
• W2107039072 hasConcept C39587587 @default.
• W2107039072 hasConcept C41625074 @default.
• W2107039072 hasConcept C49039625 @default.
• W2107039072 hasConcept C537181965 @default.
• W2107039072 hasConcept C55493867 @default.

• next