FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107052306> ?p ?o ?g. }

• W2107052306 endingPage "5901" @default.
• W2107052306 startingPage "5893" @default.
• W2107052306 abstract "To investigate the role of the Egr family of transcription regulatory factors in neuronal apoptosis, we examined the effect of a dominant negative Egr inhibitor construct in a well characterized<i>in vitro</i> paradigm, cerebellar granule cell death induced by withdrawal of depolarizing concentrations of extracellular potassium. We found that this apoptotic stimulus increases the activity of a reporter gene driven by the Egr response element and that a dominant negative inhibitor of Egr-mediated transcription blocks granule cell apoptosis. In contrast, apoptosis of immature granule cells induced by cytosine arabinoside is not inhibited by the Egr inhibitor construct. Because activation of c-Jun is an essential step in granule cell death induced by potassium deprivation, but not cytosine arabinoside, we asked whether the Egr inhibitor acts by influencing c-Jun activation or its ability to induce apoptosis. We found that the Egr inhibitor does not block the ability of a constitutively active c-Jun construct to induce apoptosis in these cells but does suppress activation of c-Jun-mediated transcription induced by lowering extracellular potassium concentration. Furthermore, the Egr inhibitor blocks the ability of MEKK1 [mitogen-activated protein kinase (MAPK) kinase kinase 1], an upstream kinase capable of stimulating the JNK (c-Jun N-terminal protein kinase)–c-Jun pathway, to induce apoptosis and activate c-Jun. Together, these studies indicate that the Egr family of transcription factors plays a critical role in neuronal apoptosis and identify c-Jun activation as an important downstream target of the Egr family in this process." @default.
• W2107052306 created "2016-06-24" @default.
• W2107052306 creator A5004108639 @default.
• W2107052306 creator A5065869401 @default.
• W2107052306 date "2001-08-15" @default.
• W2107052306 modified "2023-09-25" @default.
• W2107052306 title "A Dominant Negative Inhibitor of the Egr Family of Transcription Regulatory Factors Suppresses Cerebellar Granule Cell Apoptosis by Blocking c-Jun Activation" @default.
• W2107052306 cites W1491979926 @default.
• W2107052306 cites W1495243184 @default.
• W2107052306 cites W1527931783 @default.
• W2107052306 cites W1530284699 @default.
• W2107052306 cites W1540436551 @default.
• W2107052306 cites W1565184863 @default.
• W2107052306 cites W1567881416 @default.
• W2107052306 cites W1650797637 @default.
• W2107052306 cites W1691996697 @default.
• W2107052306 cites W1912490196 @default.
• W2107052306 cites W1945304257 @default.
• W2107052306 cites W1968015127 @default.
• W2107052306 cites W1970937164 @default.
• W2107052306 cites W1973227020 @default.
• W2107052306 cites W1984260356 @default.
• W2107052306 cites W1989114376 @default.
• W2107052306 cites W1997320822 @default.
• W2107052306 cites W2004174427 @default.
• W2107052306 cites W2029524486 @default.
• W2107052306 cites W2037791406 @default.
• W2107052306 cites W2038405912 @default.
• W2107052306 cites W2038959355 @default.
• W2107052306 cites W2045284924 @default.
• W2107052306 cites W2048121649 @default.
• W2107052306 cites W2066149485 @default.
• W2107052306 cites W2071638516 @default.
• W2107052306 cites W2072286244 @default.
• W2107052306 cites W2072329780 @default.
• W2107052306 cites W2080950632 @default.
• W2107052306 cites W2083797369 @default.
• W2107052306 cites W2090105093 @default.
• W2107052306 cites W2092368761 @default.
• W2107052306 cites W2095435531 @default.
• W2107052306 cites W2123398106 @default.
• W2107052306 cites W2125779862 @default.
• W2107052306 cites W2139488506 @default.
• W2107052306 cites W2144011146 @default.
• W2107052306 cites W2145828270 @default.
• W2107052306 cites W2147441759 @default.
• W2107052306 cites W2148175319 @default.
• W2107052306 cites W2151642254 @default.
• W2107052306 cites W2153385508 @default.
• W2107052306 cites W2155483393 @default.
• W2107052306 cites W2167921759 @default.
• W2107052306 doi "https://doi.org/10.1523/jneurosci.21-16-05893.2001" @default.
• W2107052306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6763154" @default.
• W2107052306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11487612" @default.
• W2107052306 hasPublicationYear "2001" @default.
• W2107052306 type Work @default.
• W2107052306 sameAs 2107052306 @default.
• W2107052306 citedByCount "50" @default.
• W2107052306 countsByYear W21070523062012 @default.
• W2107052306 countsByYear W21070523062013 @default.
• W2107052306 countsByYear W21070523062014 @default.
• W2107052306 countsByYear W21070523062015 @default.
• W2107052306 countsByYear W21070523062016 @default.
• W2107052306 countsByYear W21070523062018 @default.
• W2107052306 countsByYear W21070523062020 @default.
• W2107052306 countsByYear W21070523062022 @default.
• W2107052306 countsByYear W21070523062023 @default.
• W2107052306 crossrefType "journal-article" @default.
• W2107052306 hasAuthorship W2107052306A5004108639 @default.
• W2107052306 hasAuthorship W2107052306A5065869401 @default.
• W2107052306 hasBestOaLocation W21070523061 @default.
• W2107052306 hasConcept C104317684 @default.
• W2107052306 hasConcept C184235292 @default.
• W2107052306 hasConcept C185592680 @default.
• W2107052306 hasConcept C190283241 @default.
• W2107052306 hasConcept C2779087070 @default.
• W2107052306 hasConcept C31573885 @default.
• W2107052306 hasConcept C55493867 @default.
• W2107052306 hasConcept C57074206 @default.
• W2107052306 hasConcept C86339819 @default.
• W2107052306 hasConcept C86803240 @default.
• W2107052306 hasConcept C95444343 @default.
• W2107052306 hasConceptScore W2107052306C104317684 @default.
• W2107052306 hasConceptScore W2107052306C184235292 @default.
• W2107052306 hasConceptScore W2107052306C185592680 @default.
• W2107052306 hasConceptScore W2107052306C190283241 @default.
• W2107052306 hasConceptScore W2107052306C2779087070 @default.
• W2107052306 hasConceptScore W2107052306C31573885 @default.
• W2107052306 hasConceptScore W2107052306C55493867 @default.
• W2107052306 hasConceptScore W2107052306C57074206 @default.
• W2107052306 hasConceptScore W2107052306C86339819 @default.
• W2107052306 hasConceptScore W2107052306C86803240 @default.
• W2107052306 hasConceptScore W2107052306C95444343 @default.
• W2107052306 hasIssue "16" @default.
• W2107052306 hasLocation W21070523061 @default.
• W2107052306 hasLocation W21070523062 @default.
• W2107052306 hasLocation W21070523063 @default.
• W2107052306 hasLocation W21070523064 @default.

• next