FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107060906> ?p ?o ?g. }

• W2107060906 endingPage "23" @default.
• W2107060906 startingPage "13" @default.
• W2107060906 abstract "DNA glycosylases safeguard the genome by locating and excising chemically modified bases from DNA. AlkD is a recently discovered bacterial DNA glycosylase that removes positively charged methylpurines from DNA, and was predicted to adopt a protein fold distinct from from those of other DNA repair proteins. The crystal structure of Bacillus cereus AlkD presented here shows that the protein is composed exclusively of helical HEAT-like repeats, which form a solenoid perfectly shaped to accommodate a DNA duplex on the concave surface. Structural analysis of the variant HEAT repeats in AlkD provides a rationale for how this protein scaffolding motif has been modified to bind DNA. We report 7mG excision and DNA binding activities of AlkD mutants, along with a comparison of alkylpurine DNA glycosylase structures. Together, these data provide important insight into the requirements for alkylation repair within DNA and suggest that AlkD utilizes a novel strategy to manipulate DNA in its search for alkylpurine bases." @default.
• W2107060906 created "2016-06-24" @default.
• W2107060906 creator A5016821505 @default.
• W2107060906 creator A5055340496 @default.
• W2107060906 creator A5055813664 @default.
• W2107060906 creator A5056500437 @default.
• W2107060906 date "2008-08-01" @default.
• W2107060906 modified "2023-09-26" @default.
• W2107060906 title "A New Protein Architecture for Processing Alkylation Damaged DNA: The Crystal Structure of DNA Glycosylase AlkD" @default.
• W2107060906 cites W1539796472 @default.
• W2107060906 cites W1554386739 @default.
• W2107060906 cites W1565223221 @default.
• W2107060906 cites W1791564905 @default.
• W2107060906 cites W1833739857 @default.
• W2107060906 cites W1953968639 @default.
• W2107060906 cites W1966631359 @default.
• W2107060906 cites W1971650423 @default.
• W2107060906 cites W1971794652 @default.
• W2107060906 cites W1972713551 @default.
• W2107060906 cites W1974066333 @default.
• W2107060906 cites W1976385140 @default.
• W2107060906 cites W1979749286 @default.
• W2107060906 cites W1982512914 @default.
• W2107060906 cites W1983338915 @default.
• W2107060906 cites W1984886388 @default.
• W2107060906 cites W1986191025 @default.
• W2107060906 cites W1993859324 @default.
• W2107060906 cites W1994991424 @default.
• W2107060906 cites W1998426722 @default.
• W2107060906 cites W2000965284 @default.
• W2107060906 cites W2002561391 @default.
• W2107060906 cites W2002707999 @default.
• W2107060906 cites W2007259110 @default.
• W2107060906 cites W2007730035 @default.
• W2107060906 cites W2010550041 @default.
• W2107060906 cites W2018460947 @default.
• W2107060906 cites W2019148011 @default.
• W2107060906 cites W2020527412 @default.
• W2107060906 cites W2022058405 @default.
• W2107060906 cites W2023424060 @default.
• W2107060906 cites W2035072013 @default.
• W2107060906 cites W2038840577 @default.
• W2107060906 cites W2042551931 @default.
• W2107060906 cites W2049456288 @default.
• W2107060906 cites W2050320436 @default.
• W2107060906 cites W2055960140 @default.
• W2107060906 cites W2057701529 @default.
• W2107060906 cites W2059430774 @default.
• W2107060906 cites W2060929189 @default.
• W2107060906 cites W2062584177 @default.
• W2107060906 cites W2067829112 @default.
• W2107060906 cites W2074823714 @default.
• W2107060906 cites W2079470270 @default.
• W2107060906 cites W2082389145 @default.
• W2107060906 cites W2090441795 @default.
• W2107060906 cites W2094021381 @default.
• W2107060906 cites W2095103640 @default.
• W2107060906 cites W2102386127 @default.
• W2107060906 cites W2104327623 @default.
• W2107060906 cites W2110562802 @default.
• W2107060906 cites W2113226749 @default.
• W2107060906 cites W2113847441 @default.
• W2107060906 cites W2125534385 @default.
• W2107060906 cites W2125617798 @default.
• W2107060906 cites W2126361876 @default.
• W2107060906 cites W2132766092 @default.
• W2107060906 cites W2134912258 @default.
• W2107060906 cites W2136585040 @default.
• W2107060906 cites W2160419835 @default.
• W2107060906 cites W2162900968 @default.
• W2107060906 cites W2263598890 @default.
• W2107060906 cites W2346783161 @default.
• W2107060906 doi "https://doi.org/10.1016/j.jmb.2008.05.078" @default.
• W2107060906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3763988" @default.
• W2107060906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18585735" @default.
• W2107060906 hasPublicationYear "2008" @default.
• W2107060906 type Work @default.
• W2107060906 sameAs 2107060906 @default.
• W2107060906 citedByCount "41" @default.
• W2107060906 countsByYear W21070609062012 @default.
• W2107060906 countsByYear W21070609062013 @default.
• W2107060906 countsByYear W21070609062014 @default.
• W2107060906 countsByYear W21070609062015 @default.
• W2107060906 countsByYear W21070609062016 @default.
• W2107060906 countsByYear W21070609062017 @default.
• W2107060906 countsByYear W21070609062018 @default.
• W2107060906 countsByYear W21070609062019 @default.
• W2107060906 countsByYear W21070609062020 @default.
• W2107060906 countsByYear W21070609062021 @default.
• W2107060906 countsByYear W21070609062022 @default.
• W2107060906 crossrefType "journal-article" @default.
• W2107060906 hasAuthorship W2107060906A5016821505 @default.
• W2107060906 hasAuthorship W2107060906A5055340496 @default.
• W2107060906 hasAuthorship W2107060906A5055813664 @default.
• W2107060906 hasAuthorship W2107060906A5056500437 @default.
• W2107060906 hasBestOaLocation W21070609062 @default.
• W2107060906 hasConcept C104317684 @default.
• W2107060906 hasConcept C113271649 @default.

• next