Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107062893> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2107062893 endingPage "404" @default.
- W2107062893 startingPage "401" @default.
- W2107062893 abstract "The effects of prolactin on lactation and reproductive organs are well known. However, the other possible target organs and physiological consequences of altered levels of circulating prolactin remain poorly understood. In this study, mice were treated with bromocryptine, a dopamine receptor agonist that inhibits pituitary prolactin secretion. Bromocryptine treatment prevented T-cell-dependent induction of macrophage tumoricidal activity after the intraperitoneal injection of Listeria monocytogenes or Mycobacterium bovis. Coincident treatment with ovine prolactin reversed this effect. Of the multiple events leading to macrophage activation in vivo, the production by T-lymphocytes of gamma-interferon was the most impaired in bromocryptine-treated mice. Lymphocyte proliferation after stimulation with mitogens in vitro was also depressed in spleens of bromocryptine-treated mice, and coadministration of prolactin also reversed this effect. Bromocryptine treatment also reduced the number of deaths resulting from inoculation of mice with Listeria; exogenous prolactin significantly reversed this effect. The critical influence of pituitary prolactin release on maintenance of lymphocyte function and on lymphokine-dependent macrophage activation suggests that, in mice, lymphocytes are an important target tissue for circulating prolactin." @default.
- W2107062893 created "2016-06-24" @default.
- W2107062893 creator A5037836748 @default.
- W2107062893 creator A5053246297 @default.
- W2107062893 creator A5089759148 @default.
- W2107062893 date "1988-01-22" @default.
- W2107062893 modified "2023-10-18" @default.
- W2107062893 title "Suppression of Macrophage Activation and T-Lymphocyte Function in Hypoprolactinemic Mice" @default.
- W2107062893 cites W1963509529 @default.
- W2107062893 cites W1975917652 @default.
- W2107062893 cites W1976030449 @default.
- W2107062893 cites W1987754270 @default.
- W2107062893 cites W1990896009 @default.
- W2107062893 cites W1999591913 @default.
- W2107062893 cites W1999786335 @default.
- W2107062893 cites W2012704907 @default.
- W2107062893 cites W2022308523 @default.
- W2107062893 cites W2035072797 @default.
- W2107062893 cites W2056654217 @default.
- W2107062893 cites W2086454249 @default.
- W2107062893 cites W2169688475 @default.
- W2107062893 doi "https://doi.org/10.1126/science.3122324" @default.
- W2107062893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3122324" @default.
- W2107062893 hasPublicationYear "1988" @default.
- W2107062893 type Work @default.
- W2107062893 sameAs 2107062893 @default.
- W2107062893 citedByCount "373" @default.
- W2107062893 countsByYear W21070628932013 @default.
- W2107062893 countsByYear W21070628932014 @default.
- W2107062893 countsByYear W21070628932015 @default.
- W2107062893 countsByYear W21070628932016 @default.
- W2107062893 countsByYear W21070628932017 @default.
- W2107062893 countsByYear W21070628932018 @default.
- W2107062893 countsByYear W21070628932019 @default.
- W2107062893 countsByYear W21070628932020 @default.
- W2107062893 countsByYear W21070628932021 @default.
- W2107062893 countsByYear W21070628932022 @default.
- W2107062893 countsByYear W21070628932023 @default.
- W2107062893 crossrefType "journal-article" @default.
- W2107062893 hasAuthorship W2107062893A5037836748 @default.
- W2107062893 hasAuthorship W2107062893A5053246297 @default.
- W2107062893 hasAuthorship W2107062893A5089759148 @default.
- W2107062893 hasConcept C126322002 @default.
- W2107062893 hasConcept C134018914 @default.
- W2107062893 hasConcept C170493617 @default.
- W2107062893 hasConcept C202751555 @default.
- W2107062893 hasConcept C203014093 @default.
- W2107062893 hasConcept C2776659692 @default.
- W2107062893 hasConcept C2777761686 @default.
- W2107062893 hasConcept C2778938600 @default.
- W2107062893 hasConcept C2779064019 @default.
- W2107062893 hasConcept C2779234561 @default.
- W2107062893 hasConcept C2779244956 @default.
- W2107062893 hasConcept C49382859 @default.
- W2107062893 hasConcept C54355233 @default.
- W2107062893 hasConcept C55493867 @default.
- W2107062893 hasConcept C71315377 @default.
- W2107062893 hasConcept C71924100 @default.
- W2107062893 hasConcept C86803240 @default.
- W2107062893 hasConcept C8891405 @default.
- W2107062893 hasConceptScore W2107062893C126322002 @default.
- W2107062893 hasConceptScore W2107062893C134018914 @default.
- W2107062893 hasConceptScore W2107062893C170493617 @default.
- W2107062893 hasConceptScore W2107062893C202751555 @default.
- W2107062893 hasConceptScore W2107062893C203014093 @default.
- W2107062893 hasConceptScore W2107062893C2776659692 @default.
- W2107062893 hasConceptScore W2107062893C2777761686 @default.
- W2107062893 hasConceptScore W2107062893C2778938600 @default.
- W2107062893 hasConceptScore W2107062893C2779064019 @default.
- W2107062893 hasConceptScore W2107062893C2779234561 @default.
- W2107062893 hasConceptScore W2107062893C2779244956 @default.
- W2107062893 hasConceptScore W2107062893C49382859 @default.
- W2107062893 hasConceptScore W2107062893C54355233 @default.
- W2107062893 hasConceptScore W2107062893C55493867 @default.
- W2107062893 hasConceptScore W2107062893C71315377 @default.
- W2107062893 hasConceptScore W2107062893C71924100 @default.
- W2107062893 hasConceptScore W2107062893C86803240 @default.
- W2107062893 hasConceptScore W2107062893C8891405 @default.
- W2107062893 hasIssue "4838" @default.
- W2107062893 hasLocation W21070628931 @default.
- W2107062893 hasLocation W21070628932 @default.
- W2107062893 hasOpenAccess W2107062893 @default.
- W2107062893 hasPrimaryLocation W21070628931 @default.
- W2107062893 hasRelatedWork W1980606642 @default.
- W2107062893 hasRelatedWork W2010225050 @default.
- W2107062893 hasRelatedWork W2022317917 @default.
- W2107062893 hasRelatedWork W2032920953 @default.
- W2107062893 hasRelatedWork W2046867452 @default.
- W2107062893 hasRelatedWork W2087970300 @default.
- W2107062893 hasRelatedWork W2099473128 @default.
- W2107062893 hasRelatedWork W2103188824 @default.
- W2107062893 hasRelatedWork W2129625801 @default.
- W2107062893 hasRelatedWork W2167331895 @default.
- W2107062893 hasVolume "239" @default.
- W2107062893 isParatext "false" @default.
- W2107062893 isRetracted "false" @default.
- W2107062893 magId "2107062893" @default.
- W2107062893 workType "article" @default.