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• W2107070848 startingPage "1623" @default.
• W2107070848 abstract "Abstract Objective —To determine whether porcine genogroup 1 torque teno virus (g1-TTV) can infect and cause disease in gnotobiotic swine. Sample Population —20 conventional baby pigs and 46 gnotobiotic baby pigs. Procedures —Porcine g1-TTV was transmitted from conventional swine to gnotobiotic pigs via pooled leukocyte-rich plasmas (n = 18) that had positive results for g1-TTV DNA. Bone marrow–liver homogenates that had positive results for torque teno virus (TTV) were used in 4 serial passages in gnotobiotic pigs (2 pigs/passage). A pathogenesis experiment was conducted with in vivo passages of g1-TTV in various groups of gnotobiotic pigs. Results —All g1-TTV inoculated pigs had no clinical signs but developed interstitial pneumonia, transient thymic atrophy, membranous glomerulonephropathy, and modest lymphocytic to histiocytic infiltrates in the liver after inoculation with the TTV-containing tissue homogenate; these changes were not detected in uninoculated control pigs or pigs injected with tissue homogenate devoid of TTV DNAs. In situ hybridization was used to identify g1-TTV DNAs in bone marrow mononuclear cells. Conclusions and Clinical Relevance —Analysis of these data revealed that porcine g1-TTV was readily transmitted to TTV-naïve swine and that infection was associated with characteristic pathologic changes in gnotobiotic pigs inoculated with g1-TTV. Thus, g1-TTV could be an unrecognized pathogenic viral infectious agent of swine. This indicated a directly associated induction of lesions attributable to TTV infection in swine for a virus of the genus Anellovirus ." @default.
• W2107070848 created "2016-06-24" @default.
• W2107070848 creator A5017737032 @default.
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• W2107070848 date "2008-12-01" @default.
• W2107070848 modified "2023-10-14" @default.
• W2107070848 title "Evaluation of the effects of porcine genogroup 1 torque teno virus in gnotobiotic swine" @default.
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• W2107070848 doi "https://doi.org/10.2460/ajvr.69.12.1623" @default.
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