FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107072184> ?p ?o ?g. }

• W2107072184 endingPage "2381" @default.
• W2107072184 startingPage "2371" @default.
• W2107072184 abstract "To identify genes that are differently expressed in (NZB x NZW)F(1) mice with established lupus compared with healthy controls, and to determine how gene expression is affected by treatment with hCDR1 (Edratide), a peptide synthesized on the basis of the sequence of the first complementarity-determining region (CDR1) of an autoantibody.RNA was extracted from spleen cells of young, disease-free mice and of older mice with systemic lupus erythematosus (SLE) that were treated with hCDR1 or with vehicle alone. Gene expression was assessed using the DNA microarray technique and verified by real-time reverse transcriptase-polymerase chain reaction (RT-PCR).In mice with SLE, numerous genes showed increased or decreased expression relative to that in the disease-free controls. Treatment with hCDR1 restored the expression of many of these genes to control levels. Real-time RT-PCR verified that in diseased mice RNA transcripts of Tnfsf4, Il5ra, Zbtb20, and Nid1 were up-regulated, while transcripts of Tfpi and S100a8 were down-regulated, and confirmed the effects of hCDR1 on the expression of those genes. Kidney immunostaining demonstrated that the up-regulated expression of OX40 ligand, which is a protein product of the gene tumor necrosis factor (ligand) superfamily member 4, in diseased mice was reduced by hCDR1.Expression of numerous genes in mice with SLE differs from that in young, disease-free control mice. Treatment with hCDR1 restores the expression of 22% of these genes to levels similar to those in controls. Thus, one of the mechanisms by which hCDR1 exerts its beneficial effects on the clinical symptoms of SLE is through regulation of gene expression." @default.
• W2107072184 created "2016-06-24" @default.
• W2107072184 creator A5010733973 @default.
• W2107072184 creator A5020352199 @default.
• W2107072184 creator A5034596924 @default.
• W2107072184 creator A5036329250 @default.
• W2107072184 creator A5041508959 @default.
• W2107072184 creator A5054099084 @default.
• W2107072184 date "2007-07-01" @default.
• W2107072184 modified "2023-10-12" @default.
• W2107072184 title "Altered gene expression in mice with lupus treated with edratide, a peptide that ameliorates the disease manifestations" @default.
• W2107072184 cites W1504349632 @default.
• W2107072184 cites W1635285836 @default.
• W2107072184 cites W1912915587 @default.
• W2107072184 cites W1965949659 @default.
• W2107072184 cites W1973095792 @default.
• W2107072184 cites W1973502859 @default.
• W2107072184 cites W1984927734 @default.
• W2107072184 cites W1986970734 @default.
• W2107072184 cites W1995152173 @default.
• W2107072184 cites W1995665375 @default.
• W2107072184 cites W1997796758 @default.
• W2107072184 cites W2010720008 @default.
• W2107072184 cites W2019140289 @default.
• W2107072184 cites W2021598818 @default.
• W2107072184 cites W2021678927 @default.
• W2107072184 cites W2021919631 @default.
• W2107072184 cites W2028809209 @default.
• W2107072184 cites W2029865607 @default.
• W2107072184 cites W2044567576 @default.
• W2107072184 cites W2048730062 @default.
• W2107072184 cites W2050431992 @default.
• W2107072184 cites W2063480372 @default.
• W2107072184 cites W2089111295 @default.
• W2107072184 cites W2094909314 @default.
• W2107072184 cites W2096528849 @default.
• W2107072184 cites W2104743689 @default.
• W2107072184 cites W2111454506 @default.
• W2107072184 cites W2121246606 @default.
• W2107072184 cites W2125553667 @default.
• W2107072184 cites W2136342273 @default.
• W2107072184 cites W2144445604 @default.
• W2107072184 cites W2150586913 @default.
• W2107072184 cites W2156418336 @default.
• W2107072184 cites W2157151132 @default.
• W2107072184 cites W2159956236 @default.
• W2107072184 cites W2160697532 @default.
• W2107072184 cites W2161409614 @default.
• W2107072184 cites W2170989872 @default.
• W2107072184 doi "https://doi.org/10.1002/art.22736" @default.
• W2107072184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17599765" @default.
• W2107072184 hasPublicationYear "2007" @default.
• W2107072184 type Work @default.
• W2107072184 sameAs 2107072184 @default.
• W2107072184 citedByCount "14" @default.
• W2107072184 countsByYear W21070721842012 @default.
• W2107072184 countsByYear W21070721842013 @default.
• W2107072184 countsByYear W21070721842015 @default.
• W2107072184 countsByYear W21070721842017 @default.
• W2107072184 countsByYear W21070721842019 @default.
• W2107072184 countsByYear W21070721842021 @default.
• W2107072184 crossrefType "journal-article" @default.
• W2107072184 hasAuthorship W2107072184A5010733973 @default.
• W2107072184 hasAuthorship W2107072184A5020352199 @default.
• W2107072184 hasAuthorship W2107072184A5034596924 @default.
• W2107072184 hasAuthorship W2107072184A5036329250 @default.
• W2107072184 hasAuthorship W2107072184A5041508959 @default.
• W2107072184 hasAuthorship W2107072184A5054099084 @default.
• W2107072184 hasConcept C104317684 @default.
• W2107072184 hasConcept C126322002 @default.
• W2107072184 hasConcept C150194340 @default.
• W2107072184 hasConcept C153911025 @default.
• W2107072184 hasConcept C159654299 @default.
• W2107072184 hasConcept C203014093 @default.
• W2107072184 hasConcept C2776912625 @default.
• W2107072184 hasConcept C2779075594 @default.
• W2107072184 hasConcept C2779134260 @default.
• W2107072184 hasConcept C4692481 @default.
• W2107072184 hasConcept C48023723 @default.
• W2107072184 hasConcept C54355233 @default.
• W2107072184 hasConcept C71924100 @default.
• W2107072184 hasConcept C86803240 @default.
• W2107072184 hasConceptScore W2107072184C104317684 @default.
• W2107072184 hasConceptScore W2107072184C126322002 @default.
• W2107072184 hasConceptScore W2107072184C150194340 @default.
• W2107072184 hasConceptScore W2107072184C153911025 @default.
• W2107072184 hasConceptScore W2107072184C159654299 @default.
• W2107072184 hasConceptScore W2107072184C203014093 @default.
• W2107072184 hasConceptScore W2107072184C2776912625 @default.
• W2107072184 hasConceptScore W2107072184C2779075594 @default.
• W2107072184 hasConceptScore W2107072184C2779134260 @default.
• W2107072184 hasConceptScore W2107072184C4692481 @default.
• W2107072184 hasConceptScore W2107072184C48023723 @default.
• W2107072184 hasConceptScore W2107072184C54355233 @default.
• W2107072184 hasConceptScore W2107072184C71924100 @default.
• W2107072184 hasConceptScore W2107072184C86803240 @default.
• W2107072184 hasIssue "7" @default.
• W2107072184 hasLocation W21070721841 @default.

• next