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• W2107104504 abstract "The essential yeast protein Cdc13 facilitates chromosome end replication by recruiting telomerase to telomeres, and together with its interacting partners Stn1 and Ten1, it protects chromosome ends from nucleolytic attack, thus contributing to genome integrity. Although Cdc13 has been studied extensively, the precise role of its N-terminal domain (Cdc13N) in telomere length regulation remains unclear. Here we present a structural, biochemical, and functional characterization of Cdc13N. The structure reveals that this domain comprises an oligonucleotide/oligosaccharide binding (OB) fold and is involved in Cdc13 dimerization. Biochemical data show that Cdc13N weakly binds long, single-stranded, telomeric DNA in a fashion that is directly dependent on domain oligomerization. When introduced into full-length Cdc13 in vivo, point mutations that prevented Cdc13N dimerization or DNA binding caused telomere shortening or lengthening, respectively. The multiple DNA binding domains and dimeric nature of Cdc13 offer unique insights into how it coordinates the recruitment and regulation of telomerase access to the telomeres." @default.
• W2107104504 created "2016-06-24" @default.
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• W2107104504 date "2010-11-01" @default.
• W2107104504 modified "2023-10-15" @default.
• W2107104504 title "Cdc13 N-Terminal Dimerization, DNA Binding, and Telomere Length Regulation" @default.
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• W2107104504 doi "https://doi.org/10.1128/mcb.00515-10" @default.
• W2107104504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2976383" @default.
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