Matches in SemOpenAlex for { <https://semopenalex.org/work/W2107115514> ?p ?o ?g. }
- W2107115514 endingPage "16888" @default.
- W2107115514 startingPage "16883" @default.
- W2107115514 abstract "In primary cultures of adult rat hepatocytes, transcription of the albumin gene, measured as incorporation of [alpha-32P]UTP into mRNA in isolated nuclei, decreased dramatically during culture without addition of serum and hormone, becoming almost negligible 10 h after plating. Of the hormones tested, dexamethasone (0.1 microM) prevented this decrease and restored the transcription within 2 h to the same level as that before culture. The half-maximum dose of dexamethasone for induction of transcription of the albumin gene was about 30 nM. The in vitro finding that expression of the albumin gene is strictly regulated by glucocorticoid was confirmed by an in vivo experiment in adrenalectomized rats showing that the transcription decreased markedly 14 days after adrenalectomy, but was restored rapidly by administration of hydrocortisone. This finding was also supported by identification of a glucocorticoid regulatory sequence from -50 to -62 base pairs between the TATA box and CAT box upstream of the 5'-end of the albumin gene. Cycloheximide inhibited the induction of transcription of the albumin gene by dexamethasone, suggesting that a rapidly induced mediator protein, which is also regulated by glucocorticoid, is involved in the induction of albumin gene expression by glucocorticoid. The albumin gene was also regulated by various other hormones besides glucocorticoid. Glucagon markedly enhanced the transcription induced by dexamethasone, although glucagon alone had no effect. Conversely, epinephrine suppressed stimulation of expression of the albumin gene by dexamethasone. Insulin and triiodothyronine had no effect on transcription of the albumin gene. From these findings we conclude that expression of the albumin gene depends strictly on glucocorticoid, and this dependence is modulated by other hormones." @default.
- W2107115514 created "2016-06-24" @default.
- W2107115514 creator A5014708552 @default.
- W2107115514 creator A5020868859 @default.
- W2107115514 creator A5024673298 @default.
- W2107115514 creator A5077387796 @default.
- W2107115514 creator A5080102542 @default.
- W2107115514 date "1986-12-01" @default.
- W2107115514 modified "2023-10-09" @default.
- W2107115514 title "Glucocorticoid-dependent expression of the albumin gene in adult rat hepatocytes." @default.
- W2107115514 cites W1515596817 @default.
- W2107115514 cites W1598530978 @default.
- W2107115514 cites W1604711400 @default.
- W2107115514 cites W1605803926 @default.
- W2107115514 cites W1606151706 @default.
- W2107115514 cites W1636165650 @default.
- W2107115514 cites W1642066185 @default.
- W2107115514 cites W1653320450 @default.
- W2107115514 cites W1671715243 @default.
- W2107115514 cites W1674312737 @default.
- W2107115514 cites W170239507 @default.
- W2107115514 cites W1775749144 @default.
- W2107115514 cites W1847173671 @default.
- W2107115514 cites W1907162842 @default.
- W2107115514 cites W1949835994 @default.
- W2107115514 cites W1970230138 @default.
- W2107115514 cites W1977665282 @default.
- W2107115514 cites W1981071038 @default.
- W2107115514 cites W1982905517 @default.
- W2107115514 cites W1986858908 @default.
- W2107115514 cites W2007205949 @default.
- W2107115514 cites W2012949721 @default.
- W2107115514 cites W2017830116 @default.
- W2107115514 cites W2024485290 @default.
- W2107115514 cites W2026040137 @default.
- W2107115514 cites W2027720409 @default.
- W2107115514 cites W2029987769 @default.
- W2107115514 cites W2037274514 @default.
- W2107115514 cites W2042425439 @default.
- W2107115514 cites W2056072167 @default.
- W2107115514 cites W2059306166 @default.
- W2107115514 cites W2064345521 @default.
- W2107115514 cites W2066131819 @default.
- W2107115514 cites W2071219626 @default.
- W2107115514 cites W2077077811 @default.
- W2107115514 cites W2084649210 @default.
- W2107115514 cites W2086204487 @default.
- W2107115514 cites W2088856105 @default.
- W2107115514 cites W2108358343 @default.
- W2107115514 cites W2246847964 @default.
- W2107115514 cites W2337754596 @default.
- W2107115514 cites W2413911006 @default.
- W2107115514 cites W67170835 @default.
- W2107115514 cites W981450589 @default.
- W2107115514 doi "https://doi.org/10.1016/s0021-9258(19)75971-7" @default.
- W2107115514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3782147" @default.
- W2107115514 hasPublicationYear "1986" @default.
- W2107115514 type Work @default.
- W2107115514 sameAs 2107115514 @default.
- W2107115514 citedByCount "109" @default.
- W2107115514 countsByYear W21071155142014 @default.
- W2107115514 countsByYear W21071155142015 @default.
- W2107115514 countsByYear W21071155142016 @default.
- W2107115514 countsByYear W21071155142017 @default.
- W2107115514 countsByYear W21071155142019 @default.
- W2107115514 countsByYear W21071155142022 @default.
- W2107115514 crossrefType "journal-article" @default.
- W2107115514 hasAuthorship W2107115514A5014708552 @default.
- W2107115514 hasAuthorship W2107115514A5020868859 @default.
- W2107115514 hasAuthorship W2107115514A5024673298 @default.
- W2107115514 hasAuthorship W2107115514A5077387796 @default.
- W2107115514 hasAuthorship W2107115514A5080102542 @default.
- W2107115514 hasBestOaLocation W21071155141 @default.
- W2107115514 hasConcept C104317684 @default.
- W2107115514 hasConcept C126322002 @default.
- W2107115514 hasConcept C134018914 @default.
- W2107115514 hasConcept C150194340 @default.
- W2107115514 hasConcept C185592680 @default.
- W2107115514 hasConcept C2776125364 @default.
- W2107115514 hasConcept C2780841215 @default.
- W2107115514 hasConcept C55493867 @default.
- W2107115514 hasConcept C71924100 @default.
- W2107115514 hasConcept C86803240 @default.
- W2107115514 hasConceptScore W2107115514C104317684 @default.
- W2107115514 hasConceptScore W2107115514C126322002 @default.
- W2107115514 hasConceptScore W2107115514C134018914 @default.
- W2107115514 hasConceptScore W2107115514C150194340 @default.
- W2107115514 hasConceptScore W2107115514C185592680 @default.
- W2107115514 hasConceptScore W2107115514C2776125364 @default.
- W2107115514 hasConceptScore W2107115514C2780841215 @default.
- W2107115514 hasConceptScore W2107115514C55493867 @default.
- W2107115514 hasConceptScore W2107115514C71924100 @default.
- W2107115514 hasConceptScore W2107115514C86803240 @default.
- W2107115514 hasIssue "36" @default.
- W2107115514 hasLocation W21071155141 @default.
- W2107115514 hasOpenAccess W2107115514 @default.
- W2107115514 hasPrimaryLocation W21071155141 @default.
- W2107115514 hasRelatedWork W1536622731 @default.